Otavio Augusto Rodrigues

ORCID: 0000-0003-3938-8076
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About
Contact & Profiles
Research Areas
  • Virus-based gene therapy research
  • CAR-T cell therapy research
  • Immunotherapy and Immune Responses
  • Viral Infectious Diseases and Gene Expression in Insects
  • RNA Interference and Gene Delivery

Instituto do Câncer do Estado de São Paulo
2025

Universidade de São Paulo
2019-2025

Checkpoint inhibitors have revolutionized cancer treatment, but a significant proportion of patients do not respond to these therapies, underscoring the need for alternative strategies. Although gene therapy has made substantial strides, its application in solid tumors remains underexplored, with limited treatments approved. Here, we further investigated approach non-replicating adenoviral vectors encoding alternate reading frame (ARF) and interferon beta (IFNb) tested it clinically relevant...

10.1016/j.omton.2025.200942 article EN cc-by-nc-nd Deleted Journal 2025-01-01
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