A5059865469- Radiation Therapy and Dosimetry
- Radiation Detection and Scintillator Technologies
- Nuclear Physics and Applications
- Boron Compounds in Chemistry
- Radiation Effects in Electronics
- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Quantum Chromodynamics and Particle Interactions
- Particle accelerators and beam dynamics
- Nuclear reactor physics and engineering
- High-Energy Particle Collisions Research
- Prostate Cancer Diagnosis and Treatment
- Electron and X-Ray Spectroscopy Techniques
- Isotope Analysis in Ecology
- Muon and positron interactions and applications
- Digital Radiography and Breast Imaging
- Particle physics theoretical and experimental studies
- Advanced X-ray and CT Imaging
Australian Nuclear Science and Technology Organisation
2018-2025
University of Wollongong
2017-2024
National Research Nuclear University MEPhI
1994
Massachusetts Institute of Technology
1994
Lawrence Berkeley National Laboratory
1994
PurposeNeutron Capture Enhanced Particle Therapy (NCEPT) is a proposed augmentation of charged particle therapy which exploits thermal neutrons generated internally, within the treatment volume via nuclear fragmentation, to deliver biochemically targeted radiation dose cancer cells. This work first experimental demonstration NCEPT, performed using both carbon and helium ion beams with two different neutron capture agents (NCAs).Materials MethodsHuman glioblastoma cells (T98G) were irradiated...
This paper presents Neutron Capture Enhanced Particle Therapy (NCEPT), a method for enhancing the radiation dose delivered to tumour relative surrounding healthy tissues during proton and carbon ion therapy by capturing thermal neutrons produced inside treatment volume irradiation. NCEPT utilises extant in-development boron-10 gadolinium-157-based drugs from related field of neutron capture therapy. Using Monte Carlo simulations, we demonstrate that typical or plan generates an approximately...
Parallax error caused by the detector crystal thickness degrades spatial resolution at peripheral regions of field-of-view (FOV) a scanner. To resolve this issue, depth-of-interaction (DOI) measurement is promising solution to improve and its uniformity over entire FOV. Even though DOI detectors have been used in dedicated systems with small ring diameter such as for human brain, breast animals, use large bore whole-body PET system has not demonstrated yet. We developed four-layered...
Abstract Objective. To compare the accuracy with which different hadronic inelastic physics models across ten Geant4 Monte Carlo simulation toolkit versions can predict positron-emitting fragments produced along beam path during carbon and oxygen ion therapy. Approach. Phantoms of polyethylene, gelatin, or poly(methyl methacrylate) were irradiated monoenergetic beams. Post-irradiation, 4D PET images acquired parent 11 C, 10 C 15 O radionuclides contributions in each voxel determined from...
Abstract Background Geant4, a Monte Carlo Simulation Toolkit extensively used in bio‐medical physics, is continuous evolution to include newest research findings improve its accuracy and respond the evolving needs of very diverse user community. In 2014, G4‐Med benchmarking system was born from effort Geant4 Medical Benchmarking Group, benchmark monitor for medical physics applications. The first described our Physics Special Report published 2021. Results tests were reported 10.5. Purpose...
Dose and range verification have become important tools to bring carbon ion therapy a higher level of confidence in clinical applications. Positron emission tomography is among the most commonly used approaches for this purpose relies on creation positron emitting nuclei nuclear interactions primary ions with tissue. Predictions these emitter distributions are usually obtained from time-consuming Monte Carlo simulations or measurements previous treatment fractions, their comparison current,...
We present a gamma-ray detection module for quantifying the boron neutron capture events that occur in therapy (BNCT) and enhanced particle (NCEPT). The goal of is to differentiate between background prompt gamma peaks 478-keV photopeak, order estimate dose delivered patient. It compact module, coupling large array 64 silicon photomultipliers (SiPMs) with 2" <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math...
Abstract This work provides the first experimental proof of an increased neutron capture photon signal following introduction boron to a PMMA phantom during helium and carbon ion therapies in Neutron Capture Enhanced Particle Therapy (NCEPT). NCEPT leverages $$^{10}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msup> <mml:mrow /> <mml:mn>10</mml:mn> </mml:msup> </mml:math> B capture, leading emission detectable 478 keV photons. Experiments were performed at Heavy Ion...
The distribution of fragmentation products predicted by Monte Carlo simulations heavy ion therapy depend on the hadronic physics model chosen in simulation. This work aims to evaluate three alternative inelastic options available Geant4 radiation simulation framework determine which most accurately predicts production positron-emitting observable using in-beam PET imaging. Fragment distributions obtained with BIC, QMD, and INCL + models version 10.2.p03 are compared experimental data at...
The purpose of this work is to develop a validated Geant4 simulation model whole-body prototype PET scanner constructed from the four-layer depth-of-interaction detectors developed at National Institute Radiological Sciences, Institutes for Quantum and Science Technology, Japan. emulates behaviour unique depth interaction sensing capability without needing directly simulate optical photon transport in scintillator photodetector modules. was by evaluating comparing performance metrics NEMA NU...
Purpose This work has two related objectives. The first is to estimate the relative biological effectiveness of radioactive heavy ion beams based on experimental measurements, and compare these corresponding stable isotopes determine whether they are therapeutically equivalent. second aim quantitatively quality images acquired postirradiation using an in‐beam whole‐body positron emission tomography scanner for range verification assurance. Methods energy deposited by monoenergetic C at 350...
In heavy-ion therapy, the stopping position of primary ions in tumours needs to be monitored for effective treatment and prevent overdose exposure normal tissues. Positron-emitting ion beams, such as 11C 15O, have been suggested range verification therapy using in-beam positron emission tomography (PET) imaging, which offers capability visualizing with a high signal-to-noise ratio. We previously demonstrated feasibility PET imaging 15O beams observed slight shift between beam dose peak...
This work presents an iterative method for the estimation of absolute dose distribution in patients undergoing carbon ion therapy, via analysis positron annihilations resulting from decay positron-emitting fragments created target volume. The proposed relies on decomposition total positron-annihilation distributions into profiles three principal fragment species - 11C, 10C and 15O. A library basis functions is constructed by simulating a range monoenergetic 12C irradiations homogeneous...
Abstract In this study, we present a validated Geant4 Monte Carlo simulation model of the Dingo thermal neutron imaging beamline at Australian Centre for Neutron Scattering. The model, constructed using CAD drawings entire beam transport path and shielding structures, is designed to precisely predict in-beam field position sample irradiation stage. model’s performance was assessed by comparing results various experimental measurements, including planar distribution obtained gold foil...
Accurate real-time monitoring of neutron beams and distinguishing between thermal, epithermal fast components in the presence a photon background is crucial for effectiveness accelerator-based boron capture therapy (AB-BNCT). In this work, we propose an innovative quadruple metal–oxide–semiconductor field-effect transistor (MOSFET) device real-time, cost-effective beam quality control; one detector kept uncovered while other three are covered with either B4C, cadmium B4C or polyethylene...
Neutron Capture Enhanced Particle Therapy (NCEPT) boosts the effectiveness of particle therapy by capturing thermal neutrons produced beam-target nuclear interactions in and around treatment site, using tumour-specific [Formula: see text]B or text]Gd-based neutron capture agents. captures release high-LET secondary particles together with gamma photons energies 478 keV one several up to 7.94 MeV, for text]Gd, respectively. A key requirement NCEPT's translation is development vivo dosimetry...
Objective. We aim to evaluate a method for estimating 1D physical dose deposition profiles in carbon ion therapy via analysis of dynamic PET images using deep residual learning convolutional neural network (CNN). The is validated Monte Carlo simulations of12C spread-out Bragg peak (SOBP) profiles, and demonstrated with an experimental image.Approach. A set positron annihilation monoenergetic12C pencil beams PMMA are first generated simulations. From these, random polyenergetic synthesised...
This work presents a simulation study evaluating relative biological effectiveness at 10% survival fraction (RBE10) of several different positron-emitting radionuclides in heavy ion treatment systems, and comparing these to the RBE10s their non-radioactive counterparts. RBE10 is evaluated as function depth for three radioactive beams (10C, 11C 15O) two stable (12C 16O) using modified microdosimetric kinetic model (MKM) heterogeneous skull phantom subject rectangular 50 mm × 60 spread out...
Purpose: To compare the accuracy with which different hadronic inelastic physics models across ten Geant4 Monte Carlo simulation toolkit versions can predict positron-emitting fragments produced along beam path during carbon and oxygen ion therapy. Materials Methods: Phantoms of polyethylene, gelatin or poly(methyl methacrylate) were irradiated monoenergetic beams. Post-irradiation, 4D PET images acquired parent $^{11}$C, $^{10}$C $^{15}$O radionuclides contributions in each voxel determined...
Abstract In this study, we present a validated Geant4 Monte Carlo simulation model of the Dingo thermal neutron imaging beamline at Australian Centre for Neutron Scattering. The model, constructed using CAD drawings entire beam transport path and shielding structures, is designed to precisely predict in-beam field position sample irradiation stage. model’s performance was assessed by comparing results various experimental measurements, including planar spatial distribution obtained gold foil...
Abstract Neutron Capture Enhanced Particle Therapy (NCEPT) boosts the effectiveness of particle therapy by capturing thermal neutrons produced beam-target nuclear interactions in and around treatment site, using tumour-specific 10B or 157Gd-based neutron capture agents. captures release high-LET secondary particles together with prompt gamma photons energies 478 keV (10B) 7.94 MeV (157Gd). A key requirement for NCEPT’s translation is development vivo dosimetry techniques which can measure...