A5021940001- Acute Myeloid Leukemia Research
- Hemoglobinopathies and Related Disorders
- Diet and metabolism studies
- Hematological disorders and diagnostics
- Prostate Cancer Diagnosis and Treatment
- Enhanced Recovery After Surgery
- Prostate Cancer Treatment and Research
- Gut microbiota and health
- Adipose Tissue and Metabolism
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Bone and Joint Diseases
- Cancer Diagnosis and Treatment
- Erythropoietin and Anemia Treatment
- Health and Medical Research Impacts
- Heme Oxygenase-1 and Carbon Monoxide
- Neonatal Respiratory Health Research
- Pregnancy and preeclampsia studies
- Immune cells in cancer
- Cardiac Arrest and Resuscitation
- Colorectal Cancer Surgical Treatments
- Statistical Methods in Clinical Trials
- Asian Culture and Media Studies
- Trauma Management and Diagnosis
- Child and Adolescent Psychosocial and Emotional Development
- Neutropenia and Cancer Infections
University of Chicago
2020-2025
Education University of Hong Kong
2025
University of Cambridge
2015-2019
University of Alabama at Birmingham
2014-2018
Saint Louis University
2017
Sunnybrook Health Science Centre
2008-2014
Health Sciences Centre
2008-2014
University of California, Davis
2010-2014
Massachusetts General Hospital
2012
Harvard University Press
2012
Purpose We assessed the outcome of a watchful-waiting protocol with selective delayed intervention by using clinical prostate-specific antigen (PSA), or histologic progression as treatment indications for clinically localized prostate cancer. Patients and Methods This was prospective, single-arm, cohort study. were managed an initial expectant approach. Definitive offered to those patients PSA doubling time less than 3 years, Gleason score (to 4 + greater), unequivocal progression. Survival...
Exposure to irritant gases, such as bromine (Br2), poses an environmental and occupational hazard that results in severe lung systemic injury. However, the mechanism(s) of Br2 toxicity therapeutic responses required mitigate damage are not known. Previously, it was demonstrated upregulates heme degrading enzyme, oxygenase-1 (HO-1). Since is a major inducer HO-1, we determined whether increase heme-dependent oxidative injury underlies pathogenesis toxicity.C57BL/6 mice were exposed gas (600...
Pulmonary fibrosis and emphysema are irreversible chronic events after inhalation injury. However, the mechanism(s) involved in their development remain poorly understood. Higher levels of plasma lung heme have been recorded acute injury associated with several insults. Here, we provide molecular basis for heme-induced We found elevated obstructive pulmonary disease (COPD) (GOLD stage 4) patients also a ferret model COPD secondary to cigarette smoke inhalation. Next, developed rodent injury,...
No AccessJournal of UrologyAdult Urology1 Nov 2010Comparing Prostate Specific Antigen Triggers for Intervention in Men With Stable Cancer on Active Surveillance Andrew Loblaw, Liying Zhang, Adam Lam, Robert Nam, Alexandre Mamedov, Danny Vesprini, and Laurence Klotz LoblawAndrew Loblaw Department Radiation Oncology, Sunnybrook Health Sciences Centre, University Toronto, Ontario, Canada , ZhangLiying Zhang Biostatistics, LamAdam Lam Clinical Trials Epidemiology, NamRobert Nam Division Urology,...
Longevity of a p66Shc knockout strain (ShcP) was previously attributed to increased stress resistance and altered mitochondria. Microarrays ShcP tissues indicated alterations in insulin signaling. Consistent with this observation, mice were more sensitive glucose tolerant at organismal tissue levels, as novel (ShcL). Increasing decreasing Shc expression cell lines decreased sensitivity, respectively - consistent p66Shc's function repressor However, differences between the two strains also...
Economic pressure, that is, psychological stress due to not having enough money deal with everyday expenses, represents a pressing concern for many families around the globe. Indeed, prior research has linked family economic pressure academic, behavioral, and problems among children. However, most work been cross-sectional used socioeconomic status as an indicator of disadvantages. The longitudinal association child adjustment possible underlying mechanism have less well-studied, especially...
Objectives: Determine whether preoperative dietary prehabilitation with a low-fat, high-fiber diet reverses the impact of Western (WD) on intestinal microbiota and improves postoperative survival Background: We have previously demonstrated that WD fed mice subjected to an otherwise recoverable surgical injury (30% hepatectomy), antibiotics, short period starvation demonstrate reduced (29%) compared standard chow (SD) (100%). Methods: Mice were 6 weeks underwent pre-habilitation (3 days vs 7...
The effectiveness of fiscal policy to influence vehicle purchases for emissions reductions in private passenger road transport depends on its ability incentivise consumers make choices oriented towards lower vehicles. However, car purchase are known be strongly socially determined, and this sector is highly diverse due significant socio-economic differences between consumer groups. Here, we present a comprehensive dataset analysis the structure 2012 fleet-years six major economies across...
Objectives. To define the potential role of cryosurgical ablation prostate (CSAP) as a treatment option for patients with localized carcinoma (PCA), we performed retrospective outcomes analysis large database undergoing CSAP constructed from five institutions and compared this matching contemporary reports patient after radiotherapy.Methods. A total 975 who underwent primary therapy January 1993 to 1998 sufficient data available were identified. Patients stratified into three groups on basis...
Many human lung diseases, such as asthma, chronic obstructive pulmonary disease, bronchiolitis obliterans, and cystic fibrosis, are characterized by changes in the cellular composition architecture of airway epithelium. Intravital fluorescence microscopy has emerged a powerful approach mechanistic studies but it been difficult to apply this tool for vivo respiratory cell biology animals minimally invasive manner. Here, we describe novel miniature side-view confocal probe capable visualizing...
Inhalation of oxidant gases has been implicated in adverse outcomes pregnancy, but animal models to address mechanisms and studies identify potential pregnancy-specific therapies are lacking. Herein, we show that inhalation bromine at 600 parts per million for 30 minutes by pregnant mice on the 15th day embryonic development results significantly lower survival after 96 hours than an identical level exposure nonpregnant mice. On 19th day, bromine-exposed have increased systemic blood...
Summary Adipose tissue is an important metabolic organ that integrates a wide array of homeostatic processes and crucial for whole‐body insulin sensitivity energy metabolism. Brown adipose ( BAT ) key thermogenic with well‐established role in expenditure. dissipates protects against both hypothermia obesity. Thus, stimulation therapy rational strategy the looming pandemic obesity, whose consequences comorbidities have huge impact on aged. Shc‐deficient mice (Shc KO were previously shown to...
Helicobacter pylori uses natural competence and homologous recombination to adapt the dynamic environment of stomach mucosa maintain chronic colonization. Although H. is constitutive, its rate transformation variable, little known about factors that influence it. To examine this, we first determined efficiency strains under low O2 (5% O2, 7.6% CO2, H2) high (15% 2.9% conditions using DNA containing an antibiotic resistance marker. was 6- 32-fold greater tension, which robust across different...
We evaluated 52 patients with myelodysplastic syndrome (MDS) who had received at least one red blood cell (RBC) transfusion. In the 4-week period following first transfusion, 24 (group 1) required no while 28 2) transfusion of two or more units RBCs. Survival was greater in group 1 (440 weeks vs. 167 weeks, p < 0.01), even when only international prognostic scoring system (IPSS) low and intermediate-1 risk were analyzed (median overall survival 491 170 0.05), independent age, IPSS...
How can we achieve widespread adoption of surgical innovations into clinical practice quickly and frugally?