A5014853663- Gene Regulatory Network Analysis
- Nonlinear Dynamics and Pattern Formation
- Chaos control and synchronization
- Probabilistic and Robust Engineering Design
- Stability and Control of Uncertain Systems
- Microbial Metabolic Engineering and Bioproduction
- Bacterial Genetics and Biotechnology
- Evolution and Genetic Dynamics
- Molecular Communication and Nanonetworks
- Traffic control and management
- Robotic Mechanisms and Dynamics
- stochastic dynamics and bifurcation
- Advanced Control Systems Design
- Dynamics and Control of Mechanical Systems
- Railway Engineering and Dynamics
- Neural dynamics and brain function
- CRISPR and Genetic Engineering
- Stability and Controllability of Differential Equations
- Control and Stability of Dynamical Systems
- Vibration and Dynamic Analysis
- Stochastic processes and statistical mechanics
- Bioinformatics and Genomic Networks
- RNA and protein synthesis mechanisms
- Autonomous Vehicle Technology and Safety
- Evolutionary Algorithms and Applications
Rice University
2018-2023
University of Houston
2018-2023
University of Michigan
2014-2018
École Polytechnique Fédérale de Lausanne
2010-2012
Sharif University of Technology
2010-2012
Abstract As synthetic biocircuits become more complex, distributing computations within multi-strain microbial consortia becomes increasingly beneficial. However, designing distributed circuits that respond predictably to variation in consortium composition remains a challenge. Here we develop two-strain gene circuit senses and responds which strain is the majority. This involves co-repressive system each produces signaling molecule signals other down-regulate production of its own,...
Background Synthetic microbial consortia are conglomerations of genetically engineered microbes programmed to cooperatively bring about population‐level phenotypes. By coordinating their activity, the constituent strains can display emergent behaviors that difficult engineer into isogenic populations. To do so, communicate with one another through intercellular signaling pathways depend on cell density. Methods Here, we used computational modeling examine how behavior synthetic results from...
One challenge in synthetic biology is the tuning of regulatory components within gene circuits to elicit a specific behavior. This becomes more difficult microbial consortia since each strain's circuit must function at intracellular level and their combination operate population level. Here we demonstrate that dynamics can be tuned through manipulation strain fractions community. To do this, construct consortium comprised three strains engineered Escherichia coli that, when cocultured, use...
The dynamics of systems with stochastically varying time delays are investigated in this paper. It is shown that the mean can be used to derive necessary conditions for stability equilibria stochastic system. Moreover, second moment sufficient almost sure equilibria. results summarized using charts obtained via semidiscretization. theoretical methods applied simple gene regulatory networks where it demonstrated stochasticity delay improve steady protein production.
Summary In this article, the dynamics and stability of a linear system with stochastic delay additive noise are investigated. It is assumed that value sampled periodically from stationary distribution. A semi‐discretization technique used to time‐discretize derive mean second‐moment dynamics. These obtain moments corresponding necessary sufficient conditions. The application proposed method illustrated through analysis Hayes equation noise. also applied control design connected automated...
Necessary and sufficient conditions for the stability of linear continuous-time systems with stochastically switching delays are presented in this paper. It is assumed that delay random paths piece-wise constant functions time where a finite number values may be taken by delay. The assessed terms second moment state vector system. solution operators individual delays, chosen from set all possible values, extended to form new augmented operators. Then proper formulation continuous time,...
Nonlinear vibration of a three-dimensional moving gantry crane carrying trolley hoisting swinging object is studied in this paper. A finite element method used to solve nonlinear coupled governing equations the structure. combinational technique (Newmark-Runge-Kutta) employed for direct integration procedure. To develop comprehensive parametric study and sensitivity analysis system, sequence numerical simulations are carried out. Parametric directed find out how different parameters like...
In this paper the dynamics and stability of a linear system with stochastic delay are investigated. We assume that may take finitely many different values its modeled by continuous-time Markov chain. Semi-discretization is used to derive second moment which leads necessary sufficient conditions for trivial solution. apply these results investigate steady state an auto-regulatory gene-protein network. demonstrate stabilize when corresponding deterministic average unstable.
Abstract A major challenge in synthetic biology is the manipulation of engineered gene circuits toward a specified behavior. This becomes more difficult as systems become complex by incorporating additional genes or strains. Here we demonstrate that circuit dynamics can be tuned consortia through strain fractions within community. To do this, constructed microbial consortium comprised three strains Escherichia coli that, when co-cultured, use homoserine lactone (HSL) mediated intercellular...
The stability of linear continuous-time systems with stochastic delay is investigated in this paper. assumed to be a piece-wise constant function time such that it switches between finitely many different values stochastically. the system assessed terms convergence second moment state. Using infinite-dimensional solution operators, map constructed, allowing us derive necessary and sufficient conditions stability. discretization operators can used draw charts. An illustrative example...