A5034045599- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- Eating Disorders and Behaviors
- Neural and Behavioral Psychology Studies
- Pain Management and Placebo Effect
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Adipose Tissue and Metabolism
University of Calgary
2018-2023
Abstract Mesolimbic dopamine circuits, implicated in incentive motivation, are sensitive to changes metabolic state such as weight loss and diet‐induced obesity. These neurons important targets for hormones leptin, glucagon‐like peptide‐1, ghrelin insulin. Insulin receptors located on the ventral tegmental area ( VTA ) we have previously demonstrated that insulin induces long‐term depression of excitatory synapses onto neurons. While can decrease concentration somatodendritic regions, it...
ABSTRACT Early-life stress (ELS) can produce long-lasting effects that increase the risk for mood and anxiety disorders. Transdiagnostic symptoms include anhedonia (reduced reward sensitivity) sleep disruption, both of which are quantifiable via objective endpoints be utilized across species. Here we used a mouse model ELS—exposure to juvenile chronic social defeat (jCSDS)—together with translationally-applicable examine correspondence between patterns anhedonia. These initial studies...
The chronic consumption of caloric dense high-fat foods is a major contributor to increased body weight, obesity, and other health conditions. orbitofrontal cortex (OFC) critical in guiding decisions about food intake altered with diet-induced obesity. Obese rodents have morphologic synaptic electrophysiological properties the lateral (lOFC). Yet time course by which exposure diet (HFD) induces these changes poorly understood. Here, male mice are exposed either short-term (7 d) or long-term...
Abstract The lateral orbitofrontal cortex (lOFC) receives sensory information about food and integrates these signals with expected outcomes to guide future actions, thus may play a key role in distributed network of neural circuits that regulate feeding behaviour. Here, we reveal novel for the lOFC cognitive control behaviour obesity. Food-seeking is biased obesity such male obese mice, behaviours are less flexible changes perceived value outcome. Obesity associated reduced inhibitory...
Abstract The chronic consumption of caloric dense high-fat foods is a major contributor to increased body weight, obesity, and other health conditions. orbitofrontal cortex (OFC) critical in guiding decisions about food intake altered with diet-induced obesity. Obese rodents have morphological synaptic electrophysiological properties the lateral (lOFC). Yet time course by which exposure diet (HFD) induces these changes poorly understood. Here male mice are exposed either short- (7 day) or...