A5076224493- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Ion Channels and Receptors
- Pharmacological Receptor Mechanisms and Effects
- Nuclear Receptors and Signaling
- Hereditary Neurological Disorders
- Neuroscience and Neuropharmacology Research
- Microtubule and mitosis dynamics
- Tryptophan and brain disorders
- Pharmacological Effects of Natural Compounds
- Viral Infections and Vectors
- interferon and immune responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Viral Infections and Outbreaks Research
Indian Institute of Technology BHU
2019-2023
Banaras Hindu University
2019-2022
ICMR National Institute for Research in Environmental Health
2020
National Institute for Research in Reproductive Health
2020
Johns Hopkins University
2016-2019
Xi'an Jiaotong University
2019
Capital Medical University
2019
Howard Hughes Medical Institute
2018
Committee on Publication Ethics
2018
Johns Hopkins Medicine
2016-2017
Significance Chronic pain is a major health and economic problem worldwide with an estimated prevalence reaching epidemic levels of >25% the population. Most drugs on market for chronic have undesired side effects because their targets exist both inside outside pathways. Human Mas-related G protein-coupled receptor X1 (MRGPRX1) promising target novel inhibitors, mainly its restricted expression in primary nociceptive neurons. Our humanized mouse model expressing MRGPRX1 native neurons...
Several reports support the idea that µ- and δ-opioid receptors (ORs) may exist as heterodimers in brain regions involved pain signaling. The unique pharmacology of these heteromers present a novel analgesic target. However, role µ-δ sensory neurons opioid analgesia remains unclear, particularly during neuropathic pain. We examined effects spinal nerve injury on heteromer expression dorsal root ganglion (DRG) heteromer-targeting agonist, CYM51010, behavior rats mice. An L5 ligation (SNL)...
Opioids have long been regarded as the most effective drugs for treatment of severe acute and chronic pain. Unfortunately, their therapeutic efficacy clinical utility limited because central peripheral side effects.To determine value μ-opioid receptors a target neuropathic pain treatment, authors examined effects dermorphin [D-Arg2, Lys4] (1-4) amide (DALDA), hydrophilic, peripherally acting receptor agonist, in male female rats with spinal nerve ligation-induced The also utilized...
Abstract Background Ongoing neuropathic pain is difficult to treat. The authors examined whether dermorphin [D-Arg2, Lys4] (1–4) amide, a peripherally acting µ-opioid receptor agonist, attenuates ongoing pain-associated manifestations after nerve injury in rats and mice. Methods Using conditioned place preference assay, the tested animals show environment associated with drug treatment. Wide-dynamic range dorsal root ganglion neuronal activities were measured by electrophysiology recording...
Kinesin superfamily proteins transport a diverse range of cargo, including excitatory receptors to the dendrite and axon neuron via retrograde anterograde fashions along microtubules, causing central sensitization neuropathic pain. In this study, we have performed in silico molecular dynamics simulation delineate dynamic interaction betaine with KIF17, kinesin protein, known be involved The results from study suggest that betaine-KIF17 complex is stabilized through hydrogen bonding, polar...