A5102794089- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Cerebrovascular and Carotid Artery Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac electrophysiology and arrhythmias
- Venous Thromboembolism Diagnosis and Management
- Peripheral Artery Disease Management
- Blood disorders and treatments
- Blood groups and transfusion
- Neutropenia and Cancer Infections
- Cardiac Valve Diseases and Treatments
- Anesthesia and Pain Management
- Nausea and vomiting management
- Treatment of Major Depression
OLVG
2012-2025
Radboud University Nijmegen
2023
Radboud University Medical Center
2023
Patients with angina and no obstructive coronary artery disease frequently have vasomotor dysfunction as underlying pathophysiological mechanism, comprising epicardial spasm, microvascular and/or microcirculatory dysfunction. These endotypes can be diagnosed by invasive function testing which has previously shown to safe in tertiary expert centers. To determine the prevalence of patients who were clinically referred for a test (CFT); assess safety feasibility CFT. This quality improvement...
In primary percutaneous coronary intervention (PPCI), stenting has been shown to reduce the need for repeat target lesion revascularisation (TLR) compared balloon angioplasty alone, but did not result in a reduction of recurrent myocardial infarction (MI) or cardiac death. Meanwhile, stent-related adverse events such as stent thrombosis continue be concern. Our aim was evaluate safety and feasibility drug- coated (DCB) without PPCI.One hundred patients presenting with ST-elevation MI were...
The randomized REVELATION (REVascularization With PaclitaxEL-Coated Balloon Angioplasty Versus Drug-Eluting Stenting in Acute Myocardial InfarcTION) trial showed that the setting of ST-segment elevation myocardial infarction (STEMI), a drug-coated balloon (DCB) strategy was non-inferior to drug-eluting stent (DES) terms fractional flow reserve assessed at 9 months. aim present study is evaluate long-term clinical outcome this treatment strategy.
Background A coronary function test (CFT) is the recommended diagnostic to identify vasomotor dysfunction as a cause of symptoms in patients with angina and nonobstructive arteries (ANOCA). Acetylcholine commonly used pharmacological agent for spasm provocation. We aimed investigate an association between severity provocative acetylcholine dose. Methods Results included ANOCA undergoing clinically indicated CFT from Netherlands Registry Invasive Coronary Vasomotor Function Testing: NL‐CFT....
The aim of APPOSITION III was to evaluate the feasibility and performance STENTYS Self-Apposing¨ stent (STENTYS S.A., Paris, France) in setting primary percutaneous coronary intervention (PCI).APPOSITION an international, prospective, multicentre registry. study population consisted 965 patients. rate endpoint major adverse cardiac events (MACE), defined as composite death, recurrent target vessel myocardial infarction (TV-MI), clinically driven lesion revascularisation (CD-TLR), at one year...
OBJECTIVES The randomized REVELATION (REVascularization With PaclitaxEL-Coated Balloon Angioplasty Versus Drug-Eluting Stenting in Acute Myocardial InfarcTION) trial showed that the setting of ST-segment elevation myocardial infarction (STEMI), a drug-coated balloon (DCB) strategy was non-inferior to drug-eluting stent (DES) terms fractional flow reserve assessed at 9 months. aim present study is evaluate long-term clinical outcome this treatment strategy. METHODS Between October 2014 and...
In primary percutaneous coronary intervention (PPCI) for ST-elevation myocardial infarction (STEMI), stenting has proved to reduce the need repeat revascularization compared with balloon angioplasty alone. The incidence of cardiac death or recurrent infarction, though, is not reduced by stenting. This in part attributable stent-related complications like stent thrombosis which may occur even years after implantation. A strategy drug coated (DCB) without would abolish potential disadvantages...
The APPOSITION III registry evaluated the feasibility and performance of STENTYS self-apposing stent in an ST-segment elevation myocardial infarction (STEMI) population. This novel device lowers strut malapposition rates therefore carries potential to prevent undersizing during primary percutaneous coronary intervention (PCI) STEMI patients. To date, no long-term data are available using this setting STEMI. We aimed evaluate clinical outcomes registry.This was international, prospective,...
The aim of this study was to achieve useful insights into pre-hospital management and procedural performance for ST-elevation myocardial infarction (STEMI) in the Netherlands by extrapolating patient characteristics, clinical outcomes Dutch cohort from APPOSITION-III trial. This is a retrospective analysis trial with respect geographical borders STEMI management. European registry use STENTYS self-expandable stent patients undergoing primary percutaneous coronary intervention (PPCI). 965...
We sought to evaluate the procedural and clinical performances of MGuard Prime Embolic Protection Stent (EPS) in a "real-world" population with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI).Consecutive STEMI patients meeting inclusion criteria PPCI were enrolled. The endpoint was major adverse cardiac events (MACE) at 30 days, defined as composite death, (Q wave non-Q wave) or target lesion revascularization (PCI artery...
Objectives Our aim was to investigate the risk of events related non‐culprit lesions after primary percutaneous coronary intervention (PCI) in patients with multivessel disease (MVD). Background In undergoing PCI for ST‐elevation myocardial infarction (STEMI) who are diagnosed MVD, optimal treatment strategy is currently under debate. Although observational data exposed an increased acute phase STEMI, 2 recently published randomized controlled trials showed a reduction death or recurrent...
Vos, Nicola S.; Amoroso, Giovanni; Herrman, Jean-Paul R.; Patterson, Mark van der Schaaf, René J.; Slagboom, Ton; Vink, Maarten A. Author Information
We aimed to explore the impact of time percutaneous coronary intervention (PCI) (T2P) on 1-year mortality in non-ST-elevation myocardial infarction (NSTEMI) patients.The current guidelines recommend an early invasive strategy for NSTEMI patients. However, is a matter debate. For that reason, real world data are great value determine optimal treatment window.This retrospective single center cohort study was performed high-volume PCI Amsterdam, The Netherlands. Intermediate- and high-risk...
Introduction Tricyclic antidepressants (TCAs) have an important role in pharmacotherapy of Major Depressive Disorder (MDD). TCA dosing is aimed at achieving a concentration the therapeutic window. Due to inter-individual differences activity Cytochrome P450 (CYP) 2D6 and 2C19, (enzymes involved metabolism) patients require individualized dose. Currently, finding suitable dosage process trial-and-error, including multiple drug measurements dose adjustments. A starting based on patient CYP2D6...