A5058403035- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Cardiovascular and exercise physiology
- Pulmonary Hypertension Research and Treatments
- Obstructive Sleep Apnea Research
- Heart Failure Treatment and Management
- Exercise and Physiological Responses
- Inhalation and Respiratory Drug Delivery
- Cardiovascular Function and Risk Factors
- Delphi Technique in Research
- Nutrition and Health in Aging
- Nursing Diagnosis and Documentation
- Neuroscience of respiration and sleep
- Smoking Behavior and Cessation
- Health and Wellbeing Research
- Sleep and related disorders
- Pediatric health and respiratory diseases
- Venous Thromboembolism Diagnosis and Management
- Palliative Care and End-of-Life Issues
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Heart Rate Variability and Autonomic Control
- Chronic Disease Management Strategies
- Respiratory and Cough-Related Research
- School Health and Nursing Education
Radboud University Medical Center
2012-2022
Radboud University Nijmegen
2012-2022
University Medical Center
2005-2018
Erasmus MC
2018
Jeroen Bosch Ziekenhuis
2018
University Medical Center Groningen
2018
University Medical Center Utrecht
2018
Mayo Clinic
2018
Maastricht University
2018
Respiratory Clinical Trials
2017
Systemic sclerosis-associated pulmonary arterial hypertension (SScPAH) has a worse prognosis and response to (PAH) therapy than idiopathic PAH (IPAH). These differences have not yet been explained. Knowledge concerning histological vasculopathy in SScPAH is limited contrast IPAH. Therefore, we explored patterns of compared with Parameters were assessed from lung tissue eight patients cutaneous systemic sclerosis 11 IPAH patients. Lung was obtained at autopsy (n = 15), explantation 3) biopsy...
Background This study aimed to investigate whether adjunctive inspiratory muscle training (IMT) can enhance the well-established benefits of pulmonary rehabilitation (PR) in patients with COPD. Methods 219 COPD (FEV 1 : 42%±16% predicted) weakness (PImax: 51±15 cm H 2 O) were randomised into an intervention group (IMT+PR; n=110) or a control (Sham-IMT+PR; n=109) this double-blind, multicentre controlled trial between February 2012 and October 2016 (ClinicalTrials.gov NCT01397396 )....
Purpose: Physical exercise is known to induce an acute inflammatory response and oxidative stress in healthy subjects patients with chronic obstructive pulmonary disease (COPD). Increasing evidence associates systemic inflammation muscle wasting dysfunction COPD. In the present study, it was hypothesized that exercise-induced responses muscle-wasted COPD are increased compared non-muscle-wasted subjects. Methods: Pulmonary function, body composition, quadriceps strength were measured 10...
The aim of the present study was to establish agreement between two recommended definitions airflow obstruction in symptomatic adults referred for spirometry by their general practitioner, and investigate how rates change when pre-bronchodilator instead post-bronchodilator is performed. diagnostic spirometric results 14,056 with respiratory were analysed. Differences interpretation a fixed 0.70 forced expiratory volume one second (FEV(1))/forced vital capacity (FVC) cut-off point sex-...
The prevalence and incidence of systemic sclerosis (SSc) in Netherlands is unknown. same holds true for its leading causes death: pulmonary fibrosis arterial hypertension (PAH), which effective treatment options have recently become available.To establish the SSc complications.Detailed information on patients POEMAS registry, "Pulmonary Hypertension Screening, a Multidisciplinary Approach Scleroderma", consisting 819 patients, was combined with nationwide questionnaire.By combining two...
Introduction Inspiratory muscle training (IMT) has been applied during pulmonary rehabilitation in patients with chronic obstructive disease (COPD). However, it remains unclear if the addition of IMT to a general exercise programme leads additional clinically relevant improvements COPD. In this study, we will investigate whether improves 6 min walking distance, health-related quality life, daily physical activity and inspiratory function COPD weakness. Methods analysis Patients (n=170)...
Non-invasive ventilation (NIV) improves survival and quality of life in amyotrophic lateral sclerosis (ALS) patients. The timing referral to a home service (HVS), which is part based on respiratory function tests, has shown room for improvement. It currently unknown test predicts an appropriate the initiation NIV.We analysed, retrospectively, serial data five tests: forced vital capacity (FVC), peak cough flow (PCF), maximum inspiratory expiratory pressure (MIP MEP) sniff nasal (SNIP)...
Background Many patients with chronic obstructive pulmonary disease (COPD) suffer from exacerbations, a worsening of their respiratory symptoms that warrants medical treatment. Exacerbations are often poorly recognized or managed by patients, leading to increased burden and health care costs. Objective This study aimed examine the effects smart mobile (mHealth) tool supports COPD in self-management exacerbations providing predictions early exacerbation onset timely treatment advice without...
Hepatopathy is the most common feature in Congenital Disorders of Glycosylation (CDG). More than 70 subtypes have been identified this growing group inborn errors. Most defects present as multisystem disease, whereas phosphomannose isomerase deficiency (MPI-CDG) presents with exclusive hepato-intestinal phenotype. MPI-CDG has considered one very few treatable disorders glycosylation; several patients showed significant improvement their life-threatening protein-losing enteropathy and...
<h3>Objective</h3> To describe the clinical phenotype and recovery of diaphragm dysfunction caused by neuralgic amyotrophy in a large cohort patients, to improve accurate awareness this entity, encourage adoption standardized approach for diagnosis treatment. <h3>Methods</h3> This observational study recruited adult patients with symptoms idiopathic phrenic neuropathy from database Dutch expert center centers home mechanical ventilation. Demographic information on diagnosis, symptoms, was...
To compose a battery of instruments that provides detailed assessment health status (HS) in COPD but is applicable and clinically meaningful routine care.In previous study, we developed the Nijmegen Integral Assessment Framework (NIAF) organizes existing tests by sub-domains HS they measure. Based on clinical statistical criteria (correlation coefficients Cronbach alpha's) selected for each sub-domain from NIAF. A COPD-study group was used to determine c-scores, two control groups were score...
Background and aim: Patients with advanced chronic obstructive pulmonary disease (COPD) have poor quality of life. The aim this study was to assess the effects proactive palliative care on well-being these patients. Trial registration: This trial is registered Netherlands Register, NTR4037. methods: A pragmatic cluster controlled (quasi-experimental design) performed hospitals as (three intervention three control) a pretrial assessment performed. Hospitals were selected for group based...
Although oxygen therapy is of clear benefit in patients with severe chronic obstructive pulmonary disease (COPD), recent studies have shown that short-term supplementary may increase oxidative stress and inflammation within the airways.We investigated whether systemic at rest during exercise COPD are influenced by supplemental oxygen.Nine normoxemic, muscle-wasted moderate to very were studied. Plasma markers (leukocyte counts, interleukin 6 [IL-6]) (lipid peroxidation, protein oxidation,...