A5003473265- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Zebrafish Biomedical Research Applications
- Physiological and biochemical adaptations
- RNA modifications and cancer
- Fish biology, ecology, and behavior
- Pancreatic function and diabetes
- Fish Ecology and Management Studies
- Photosynthetic Processes and Mechanisms
- Lipid metabolism and biosynthesis
- RNA regulation and disease
- Coral and Marine Ecosystems Studies
- Aquaculture Nutrition and Growth
National Cancer Institute
2021-2024
Center for Cancer Research
2021-2024
Harvard University
2023-2024
Trinity College
2019-2020
Hartford Financial Services (United States)
2019-2020
How RNA-binding proteins (RBPs) convey regulatory instructions to the core effectors of RNA processing is unclear. Here, we document existence and functions a multivalent RBP-effector interface. We show that effector interface conserved RBP with an essential role in metazoan development, Unkempt, mediated by novel type 'dual-purpose' peptide motifs can contact two different surfaces interacting proteins. Unexpectedly, find contacts do not merely serve recruitment but are required for...
Abstract The CCR4-NOT complex acts as a central player in the control of mRNA turnover and mediates accelerated degradation upon HDAC inhibition. Here, we explored acetylation-induced changes composition by purification endogenously tagged scaffold subunit NOT1 identified RNF219 an acetylation-regulated cofactor. We demonstrate that is active RING-type E3 ligase which stably associates with via NOT9 through short linear motif (SLiM) embedded within C-terminal low-complexity region RNF219. By...
The external environment influences brain cell proliferation, and this might contribute to plasticity underlying adaptive behavioural changes. Additionally, internal genetic factors influence the proliferation rate. However, date, researchers have not examined importance of environmental versus in causing natural variation proliferation. Here, we examine growth trajectories free-living populations Trinidadian killifish, Rivulus hartii , exposed contrasting predation environments. Compared...
ABSTRACT RNA-binding proteins (RBPs) are key regulators of gene expression, but how RBPs convey regulatory instructions to the core effectors RNA processing is unclear. Here we document existence and functions a multivalent RBP–effector interface. We show that effector interface deeply conserved RBP with an essential role in metazoan development, Unkempt, mediated by novel type ‘dual-purpose’ peptide motifs can contact two different surfaces interacting proteins. Unexpectedly, find contacts...
Abstract In many species, the negative effects of aversive stimuli are mitigated by social interactions, a phenomenon termed buffering. one form buffering, interactions reduce inhibition brain cell proliferation during stress. Indirect predator (e.g., olfactory or visual cues) known to decrease proliferation, but little is about how somatic injury, as might occur from direct encounter, affects and whether this response influenced conspecific interactions. Here, we assessed buffering in an...