A5048241330- Peptidase Inhibition and Analysis
- Signaling Pathways in Disease
- Ubiquitin and proteasome pathways
- HIV Research and Treatment
- Genomics and Chromatin Dynamics
- Cancer Mechanisms and Therapy
- CRISPR and Genetic Engineering
- Cell death mechanisms and regulation
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Protein Degradation and Inhibitors
- interferon and immune responses
- ATP Synthase and ATPases Research
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
Université de Montpellier
2020-2022
Centre National de la Recherche Scientifique
2020-2022
Institut de Génétique Moléculaire de Montpellier
2020-2021
La Ligue Contre le Cancer
2020
Harvard University
2015
Brigham and Women's Hospital
2015
Abstract Promoter-proximal pausing of RNA polymerase II is a key process regulating gene expression. In latent HIV-1 cells, it prevents viral transcription and essential for latency maintenance, while in acutely infected cells the factor Tat releases paused to induce Pausing fundamental HIV-1, but how contributes bursting stochastic reactivation unclear. Here, we performed single molecule imaging transcription. We developed quantitative analysis method that manages multiple time scales from...
// Nadiya M. Teplyuk 1 , Erik J. Uhlmann Andus Hon-Kit Wong Priya Karmali 2 Meenakshi Basu Galina Gabriely Anant Jain Yang Wang E. Antonio Chiocca 3 Robert Stephens 4 Eric Marcusson Ming Yi Anna Krichevsky Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA Regulus Therapeutics, Inc., San Diego, CA, Neurosurgery, Cancer Research Technology Program, Frederick National Laboratory for Research, Leidos Biomedical Frederick, MD, Correspondence to:...
Summary Promoter-proximal polymerase pausing is a key process regulating gene expression. In latent HIV-1 cells, it prevents viral transcription and essential for latency maintenance, while in acutely infected cells the factor Tat releases paused to induce Pausing fundamental HIV-1, but how contributes bursting stochastic reactivation unclear. Here, we performed single molecule imaging of transcription, developed quantitative analysis method that manages multiple time scales from seconds...
Abstract NFATc3 is the predominant member of NFAT family transcription factor in neurons, where it plays a pro-apoptotic role. Mechanisms controlling protein stability are poorly understood. Here we identify Trim39 as an E3 ubiquitin-ligase NFATc3. Indeed, ubiquitinates vitro and cells, whereas silencing endogenous decreases ubiquitination. We also show that Trim17 inhibits Trim39-mediated ubiquitination by reducing both activity NFATc3/Trim39 interaction. Moreover, mutation SUMOylation...