A5001299066- Bone Metabolism and Diseases
- Protease and Inhibitor Mechanisms
- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- Bone and Dental Protein Studies
- Bone health and treatments
- Cell Adhesion Molecules Research
- Genetics, Bioinformatics, and Biomedical Research
- Immune Response and Inflammation
- Innovative Teaching Methods
- RNA Interference and Gene Delivery
- Endodontics and Root Canal Treatments
- Osteoarthritis Treatment and Mechanisms
- Cancer Cells and Metastasis
- Various Chemistry Research Topics
- Immune Cell Function and Interaction
- Endometriosis Research and Treatment
- Biomedical and Engineering Education
- Cancer-related Molecular Pathways
- Systemic Lupus Erythematosus Research
- Molecular Biology Techniques and Applications
- Uterine Myomas and Treatments
- Reproductive System and Pregnancy
- Cellular Mechanics and Interactions
- Collagen: Extraction and Characterization
QB3
2022-2023
University of California, Los Angeles
2018-2023
Laboratory of Molecular Genetics
2022
University of California, San Francisco
2022
The Wallace H. Coulter Department of Biomedical Engineering
2015-2019
Georgia Institute of Technology
2010-2019
Massachusetts Institute of Technology
2009
To develop new and effective chemopreventive agents against bone metastasis, we assessed the effects of muscadine grape skin extract (MSKE), whose main bioactive component is anthocyanin, on turnover, using prostate breast cancer cell models overexpressing Snail transcription factor. MSKE has been shown previously to promote apoptosis in cells without affecting normal epithelial cells. overexpressed cancer, associated with increased invasion, migration turnover/osteoclastogenesis. Cathepsin...
Abstract Bone marrow-derived multipotent stromal cells (MSCs) offer great promise for regenerating tissue. Although certain transcription factors have been identified in association with tendency toward particular MSC differentiation phenotypes, the regulatory network of key receptor-mediated signaling pathways activated by extracellular ligands that induce various responses remains poorly understood. Attempts to predict fate tendencies from individual isolation are problematic due complex...
Type I interferons (IFN) induce powerful antiviral and innate immune responses via the transcription factor, IFN-stimulated gene factor (ISGF3). However, in some pathological contexts, type IFNs are responsible for exacerbating inflammation. Here, we show that a high dose of IFN-β also activates an inflammatory expression program contrast to IFN-λ3, III IFN, which elicits only common program. We depends on second, potentiated phase ISGF3 activation. Iterating between mathematical modeling...
Cathepsins are powerful proteases, once referred to as the lysosomal cysteine that have been implicated in breast cancer invasion and metastasis, but pharmaceutical inhibitors suffered failures clinical trials due adverse side effects. Scientific advancement from lysosomotropic cell impermeable cathepsin improved efficacy treating disease, off-target effects still problematic, motivating a need better understand cellular feedback responses treatment with inhibitors. To address this need, we...
To address ongoing academic achievement gap, there is a need for more school-university partnerships promoting early access to STEM education. During summer 2020, members of our institute initiated QBio-EDGE (Quantitative Biology-Empowering Diversity and Growth in Education), an outreach program high schools Los Angeles. In the hope contributing increasing diversity academia, aims make education accessible students from historically excluded communities by exposing them scientific research...
Interferon β (IFN- ) signaling activates the transcription factor complex ISGF3 to induce gene expression programs critical for antiviral defense and host immune responses. It has also been observed that IFN- a second complex, γ-activated (GAF), but significance of this coordinated activation is unclear. We report in murine lung epithelial cells (MLE12) high doses indeed activate both GAF, which bind distinct genomic locations defined by their respective DNA sequence motifs. In contrast, low...
Cysteine cathepsins are powerful elastases and collagenases, produced by breast cancer cells tumor associated macrophages, capable of remodeling extracellular matrix driving growth metastasis. Cathepsin expression activity regulated endogenous protein inhibitors as well proteolytic interactive networks that not completely understood. To date, no cathepsin have cleared clinical trials due to side effects including increased stroke risk. Surprisingly, inhibitor treatment has been with...
Abstract Interferon β (IFN- ) signaling activates the transcription factor complex ISGF3 to induce gene expression programs critical for antiviral defense and host immune responses. It has also been observed that IFN- a second factor, γ-activated (GAF), but significance of this coordinated activation is unclear. We report in respiratory epithelial cells high doses indeed activate both GAF, which bind distinct genomic locations defined by their respective DNA sequence motifs. In contrast, low...
The education system in the US displays troubling disparities academic performance of different racial and income groups, known as achievement gap. During summer 2020, our research group committed to promoting ethnic diversity academia reduce gap Los Angeles. Since educators with a growth mindset employing active learning their classrooms can elevate students from underrepresented minority groups STEM fields, we initiated QBio-EDGE (Quantitative Biology - Empowering Diversity Growth...
ABSTRACT Type I interferons (IFN) induce powerful anti-viral and innate immune responses via the transcription factor, IFN-stimulated gene factor (ISGF3). However, in some pathological contexts type IFNs are responsible for exacerbating inflammation. Here, we show that a high dose of IFN-β also activates an inflammatory expression program contrast to IFN-λ3, III IFN, which elicits only common program. We depends on second, potentiated phase ISGF3 activation. Iterating between mathematical...