A5100698275- Superconducting Materials and Applications
- Particle accelerators and beam dynamics
- Fusion materials and technologies
- Non-Destructive Testing Techniques
- Magnetic confinement fusion research
- High-Velocity Impact and Material Behavior
- HVDC Systems and Fault Protection
- Chronic Myeloid Leukemia Treatments
- Cellular and Composite Structures
- Hydraulic and Pneumatic Systems
- Ultrasonics and Acoustic Wave Propagation
- Transportation Safety and Impact Analysis
- Aluminum Alloys Composites Properties
- Magnetic Properties and Applications
- Chronic Lymphocytic Leukemia Research
- Physics of Superconductivity and Magnetism
- High Entropy Alloys Studies
- Thermal Analysis in Power Transmission
- Robotic Mechanisms and Dynamics
- Neurofibromatosis and Schwannoma Cases
- Vibration Control and Rheological Fluids
- Ultrasound Imaging and Elastography
- Vehicle Dynamics and Control Systems
- Electromagnetic Launch and Propulsion Technology
- Structural Response to Dynamic Loads
Institute of Plasma Physics
2013-2024
Chinese Academy of Sciences
2013-2024
Hefei Institutes of Physical Science
2017-2024
Yanshan University
2019-2021
University of Science and Technology of China
2016-2020
Changzhou Institute of Mechatronic Technology
2020
Commercial Aircraft Corporation of China (China)
2019
High Magnetic Field Laboratory
2017
Northwestern Polytechnical University
2013
Abstract This study investigates the macroscopic mechanical properties of 2D SiC/SiC composite materials through axial tensile tests conducted at room temperature, 1200°C argon atmosphere, and 1200°C/4kPa oxygen partial pressure. Scanning electron microscopy is employed to analyze fracture surfaces under varying environmental conditions. The results show significant nonlinear stress-strain curves in all three temperature environments, with a 10% reduction strength observed atmosphere...
BTK plays a critical role in the B cell receptor mediated inflammatory signaling rheumatoid arthritis (RA). Through rational design approach we discovered highly selective and potent kinase inhibitor (CHMFL-BTK-11) which exerted its inhibitory efficacy through covalent bond with Cys481. CHMFL-BTK-11 potently blocked anti-IgM stimulated BCR Ramos lines isolated human primary cells. It significantly inhibited LPS TNF-α production PBMC cells but only weakly affecting normal proliferation. In...
BMX is a member of TEC family nonreceptor tyrosine kinase and involved in variety critical physiological pathological processes. Through combination irreversible inhibitor design type II approaches, we have discovered highly selective potent compound 41 (CHMFL-BMX-078), which exhibited an IC50 11 nM by formation covalent bond with cysteine 496 residue the DFG-out inactive conformation BMX. It displayed high selectivity profile (S score(1) = 0.01) against 468 kinases/mutants KINOMEscan...
China fusion engineering test reactor (CFETR) central solenoid model coil (CSMC) made with cable in conduit conductor superconductor had been developed the Institute of Plasma Physics, Chinese Academy Sciences. The highest magnetic field CSMC is 12 T when running current 47.65 kA at 4.5 K, and largest change rate 1.5 T/s. mainly consists one Nb <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> Sn inner coil, outer three NbTi coils cooled...
The design and development of highly stable Cable-in-Conduit Conductor (CICC) technology are paramount importance to enable REBCO fusion magnets operate in magnetic fields exceeding 20T. As part the ongoing efforts advance CICC, technique twist-forming plays a pivotal role fabrication process. It is instrumental achieving uniform current distribution, enhancing conductor stability, improving mechanical strength cable, reducing AC losses. Consequently, ASIPP has designed developed two...
The ITER in-vessel coils are comprised of edge-localized mode (ELM) and vertical stabilization (VS) coils. There 27 ELM 2 VS All the supported by clamped brackets bolted to rails which welded vacuum vessel wall. environment is severe, characterized large transient electromagnetic fields, high radiation flux, temperature. Therefore, an appropriate nondestructive examination approach should be established qualified. difficulty in development bracket weld complex structure brings space limit...
To study the crashworthiness of a civil airplane fuselage section under vertical crash condition, finite element model this was developed, and numerical simulations 7m/s impact condition is performed using LS-DYNA explicit code. Then drop test structure conducted, surface wooden platform instrumented with 12 load cells. The passengers were simulated by 15 dummies, 4 them instrumented, passenger baggage concentrated weights. loads acceleration responses dummies collected data acquisition...
KIT kinase V559D mutation is the most prevalent primary gain-of-function in Gastrointestinal Stromal Tumors (GISTs). Here we reported a highly selective inhibitor CHMFL-KIT-031, which displayed about 10-20 fold selectivity over wt biochemical assay (IC50: 28 nM 168 nM; Kd: 266 versus 6640 nM) and cell (EC50: 176 2000 for pY703) examination. It also 15∼400-fold other mutants such as L576P secondary including T670I, V654A (ATP binding pocket) well N822K D816V (activation loop). In addition, it...
This paper proposes a new passive shimming method to design correction iron pieces for compensating field impurities generated by the main magnets of high magnetic resonance imaging (MRI) human body imaging. First, relationship formula dipole any point in space is established. Then, sensitivity matrix form spherical harmonic expansions can be set up based on contribution each shim piece point. Next, an optimization procedure linear programming applied determine location and thickness...
The central solenoid model coil (CSMC) is a large superconducting “model” coil, which responsible for developing and verifying the key manufacturing methods of China Fusion Engineering Test Reactor. Therefore, all subcomponents have very strict requirements, including conductors are cable-in-conduit conductor (CICC) type. jacket section as an important component CSMC CICC circular-in-square type, nonmagnetic stainless steel. Severe requirements not only high mechanical performances but also...
As one of the sub-systems for comprehensive research facility fusion technology (CRAFT), SC material testing will be used performance on superconducting wires/tapes, structural materials , insulations, and other subelements magnet systems. The consists 6 platforms including platform, AC loss structure thermohydraulic non-destructive examination high voltage platform. following key technologies are expected to solved during establishment platform: design manufacturing a 19 T hybrid with an...
The In-Vessel Coils (IVCs) are resistive and located inside the vacuum vessel behind Blanket Shield Modules (BSM). There two types of IVCs: 27 Edge Localized Modes (ELM) coils equally distributed around wall, with three in each nine sectors, namely Upper ELM, Equatorial ELM Lower 2 Vertical Stabilization (VS) ring-shaped coils, one upper lower. a total 176 IVC joints for joining IVCs, feeders, feedthroughs. All have to be manufactured ITER Vacuum Vessel (VV) made stainless steel mineral...
Circular sandwich panels were designed with Aluminium being core material, steel and Al-Al-based high entropy alloy (Al-based HEA) as the surface board materials, respectively. The dynamic response influence of small changes in thickness inherent properties (poisson ratio density) are investigated by a three-dimensional finite element modeling. nonlinear vibration panel from steady state to multiple-periods-bifurcation chaotic changing forced excitation frequency, amplitude initial...
The conductors used in large fusion reactors, e.g.ITER, CFETR and DEMO, are made of cable-inconduit conductor (CICC) with diameters up to about 50 mm.The superconducting copper strands cabled around a central spiral then wrapped stainless-steel tape 0.1 mm thickness.The cable is inserted into jacket under tensile force that increases the length insertion.Because cables long diameter, insertion could reach values 40 kN.The lead significant rotation forces.This may an increase twist pitch,...
The Chinese Fusion Engineering Testing Reactor (CFETR) is aiming to bridge the gap between International Thermonuclear Experimental (ITER) and first commercial fusion power plant, a necessary complement of ITER. requirement for sustaining long burn duration as specified in duty time CFETR mission necessitates use superconducting magnets. Totally 16 toroidal field (TF)D-shaped coils which are cable-in-conduit conductor type designed. All subcomponents have very demanding withstand severe...
Nb <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> Sn cable-in-conduit conductor (CICC) technology is widely applied to the large-scale superconducting magnets. Due multi-level composite structure, it easy cause partial damage or even strand breakage of cable in complex deformation mode. To evaluate CICC, direct current potential drop (DCPD) technique proposed this study. Serious benchmark samples with stage 3 were prepared and different...
The ITER magnet system is one of the largest and most complex superconducting installations ever undertaken. Therefore, all subcomponents have very demanding requirements, including conductors which are cable-in-conduit conductor type. Based on structural analysis fatigue life requirements coil systems, maximum acceptable defect sizes inside jacket material were defined. This paper presents nondestructive test (NDT) method developed for poloidal field (PF) jackets made 316L stainless steel....