Cobalamin deficiency has well-known hematologic and neurologic effects, but little is known about its other effects. We therefore studied the effect of cobalamin on osteoblast-related proteins. found that mean (+/- 1 SD) levels skeletal alkaline phosphatase in blood were lower 12 cobalamin-deficient patients (3.89 +/- 2.19 units per liter) than 5 nondeficient iron-deficient control subjects (7.55 3.99 liter). The degree megaloblastic anemia correlated with reduction (r = 0.67, P less 0.01)....

Purpose The study examines the production, operational, technological, environmental, economic and financial risks affecting agribusinesses. primary objective is to identify prioritise barriers humanitarian system's operational dynamics that focus on indemnifying farmers' income in India. Design/methodology/approach integrated interpretive structural modelling (ISM)-fuzzy analytical network process (FANP) approach systematically analyses dynamic interrelationships among barriers, offering a...

BACKGROUND: The Joint Commission on the Accreditation of Healthcare Organizations requires that hospitals have a planned approach to systematically collect data processes related use, ordering, and administering blood components. This study describes how comprehensive blood‐administering assessment program FOCUS‐PDCA improved overall practices. STUDY DESIGN AND METHODS: Nurses were trained observe issuance, administering, patient monitoring steps, audit patient's charts measure compliance...

Trypanosoma cruzi, the cause of Chagas' disease, is often transmitted by transfusion in Latin America. Previous studies showed that at least 1 1000 eligible blood donors Los Angeles County+University Southern California (LAC+USC) Medical Center Blood Bank had specific antibodies to T. cruzi. In June 1993, serologic screening prospective allogeneic epidemiologic risk for cruzi infection was begun voluntarily.The all assessed questionnaire. At-risk were screened serologically with an enzyme...

<b>Aims:</b> This study aimed to elucidate the early renal changes in diabetes mellitus (DM) with and without clinical symptoms related damage. <b> Methods:</b> Renal biopsy was studied 25 patients (14 microalbuminuria 11 albuminuria) both by light electron microscopies (LM EM, respectively) for morphometry performed glomerular tubular basement membranes (GBM TBM, width using a Soft Imaging System GmBH (analysis 3). Results:</b> A significant increase noted mean GBM TBM thickness preclinical...

Using the principles of continuous quality improvement (CQI), authors conducted a study in response to request from Department Emergency Medicine, Los Angeles County, and University Southern California Medical Center, Angeles, for dedicated stat laboratory emergency department. The orders test serum electrolyte, glucose, blood urea nitrogen, creatinine, amylase, lipase levels, prothrombin time, complete count (CBC) were evaluated. was done two phases. First, baseline on turnaround time...

Journal Article Racial Differences in Vitamin B12 Levels the United States Get access Sunita Saxena, M.D., M.D. Interpretive Clinical Pathology Unit, Section of Laboratories and Pathology, Hematology Division, Department Medicine, Los Angeles County-University Southern California Medical Center, Departments University School Angeles, Search for other works by this author on: Oxford Academic Google Scholar Ralph Carmel, American Volume 88, Issue 1, 1 July 1987, Pages 95–97,...

Squamous cell carcinoma of the scrotum is rare and its development in scar Fournier's gangrene still rarer. A 65-year-old gentleman presented with a small non-healing ulcer developing on right hemi-scrotum two years after treatment for gangrene. On histological examination it was found to be squamous carcinoma. He successfully managed by surgery form wide local excision ilio-inguinal lymph node dissection followed adjuvant radiotherapy chemotherapy. can develop long delay, which...

Two neonates who became infected with Plasmodium vivax subsequent to exchange transfusion are described. This complication of neonatal is unusual in that only two other similar cases have been reported the Centers for Disease Control. Although malaria an complication, it should be kept mind when considering differential diagnoses fever following transfusion. The risk transfusion-induced may increasing due influx immigrants from areas endemic malaria. Careful blood donor selection and...

<h3>Objective:</h3> Blood transfusion raises serious issues of safety and economics. We therefore examined blood usage its characteristics in medical inpatients, given the relative scarcity existing data. <h3>Design:</h3> During a 1-year period, episodes on two services were reviewed by five specialists for justifiability basis generally agreed guidelines. <h3>Setting:</h3> The study was conducted at institutions, municipal teaching hospital where house staff deliver care community patients...

Journal Article Red Blood Cell Distribution Width in Untreated Pernicious Anemia Get access Sunita Saxena, M.D., M.D. Interpretive Clinical Pathology Unit, Section of Laboratories and Pathology, the Department Medicine, Los Angeles, County University Southern California Medical Center, Departments School Search for other works by this author on: Oxford Academic Google Scholar John M. Weiner, Dr. P.H., P.H. Ralph Carmel, American Volume 89, Issue 5, 1 May 1988, Pages 660–663,...

Three years' experience with the routine use of an abbreviated crossmatch procedure is reported. If a patient had no known history and/or currently demonstrable unexpected antibodies, ABO and Rh type specific blood was crossmatched at time need by using immediate spin saline crossmatch. Once issued, both 37 degrees C incubation antiglobulin were done same tube employed for This served as check that clinically significant antibodies not overlooked. None 19,818 patients transfused following...

BACKGROUND: Monitoring blood transfusion for overutilization is standard practice at most institutions. STUDY DESIGN AND METHODS: This study monitored underutilization of over a 14‐month period, by evaluating patients who had Hb levels that were reported to be &lt;5 g per dL or platelet counts &lt;10 × 10 9 L and did not receive an RBC within 24 hours the results. RESULTS: During 24,004 units RBCs 3,967 apheresis platelets transfused. There 148 level was count during after reporting these In...

Abstract The risk that a red blood cell unit will be associated with an ABO-incompatible transfusion is currently slightly greater than the aggregate of acquiring human immunodeficiency virus, T-cell lymphotropic hepatitis B or C virus by transfusion. Since most common cause for failure transfusionists to properly identify patient component before transfusion, services are encouraged evaluate and monitor processes dispensing administering blood. In addition, proposal Health Care Financing...

Abstract Context.—A blood bank can provide compatible for an elective surgical procedure, provided a sample is received by the laboratory with sufficient time to allow pretransfusion testing and acquire enough red cell units. With push same-day admission procedures, patient's often collected morning of surgery. However, if needed, units might not be immediately available. Objective.—To define improve process completing presurgical/preadmission type screen verifying ABO/Rh status scheduled...

Abstract Healthcare institutions in the United States must review blood transfusion practices and adverse outcomes order to receive payments from Centers for Medicare/Medicaid program, but it is not required a specific committee be assigned oversee process. Regardless of group or individuals responsible, process include program quality assessment performance improvement that ongoing, hospital-wide, data-driven, reflects complexity hospital’s organization services, involves all hospital...

The risk that a red blood cell unit will be associated with an ABO-incompatible transfusion is currently slightly greater than the aggregate of acquiring human immunodeficiency virus, T-cell lymphotropic hepatitis B or C virus by transfusion. Since most common cause for failure transfusionists to properly identify patient component before transfusion, services are encouraged evaluate and monitor processes dispensing administering blood. In addition, proposal Health Care Financing...

Fresh-frozen plasma (FFP) and cryoprecipitate both contain Factors I VIII, however thawed FFP may be stored at 1-6 degrees C for 24 hours, but only six hours when used Factor VIII content. To determine whether it would safe effective to extend the storage period of from 6 (and fibrinogen) levels were measured in 25 units cryoprecipitates immediately on thawing thereafter. The activity level decreased 86% original within drop between was relatively small. Eighty percent still present after...

Most transfusion services discard unopened units of blood that have been returned to the bank more than 30 minutes after issuance or attained a temperature 10 degrees C. The objective this study was learn prevalence bacterial growth, if any, in were exposed twice, for six hours each time, room during their refrigerated storage. All 396 cultured negative except one red cell unit grew Bacillus species, probably B. subtilis. Further studies suggested growth subtilis due laboratory...

Documented differences exist in red blood cell (RBC) and granulocyte counts between black white people. However, little comparative information is available on platelet the two racial groups. Therefore, this study was performed to compare healthy (94), (92), Latin-American (63) persons. Black women had significantly higher than did (P less 0.025). were other No noted among men. also a prevalence of iron deficiency microcytosis RBCs women. After exclusion with either or deficiency, no longer...