A5007270786- Inhalation and Respiratory Drug Delivery
- Transplantation: Methods and Outcomes
- Advanced Drug Delivery Systems
- Microencapsulation and Drying Processes
- Drug Solubulity and Delivery Systems
- Pulmonary Hypertension Research and Treatments
- Nanoparticle-Based Drug Delivery
- Asthma and respiratory diseases
- Aerosol Filtration and Electrostatic Precipitation
- Renal Transplantation Outcomes and Treatments
- Cystic Fibrosis Research Advances
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lipid Membrane Structure and Behavior
- Advancements in Transdermal Drug Delivery
- Polyomavirus and related diseases
- Surfactants and Colloidal Systems
- Mechanical Circulatory Support Devices
- Respiratory viral infections research
- Ion channel regulation and function
- Neuropeptides and Animal Physiology
- Respiratory Support and Mechanisms
- Organ Transplantation Techniques and Outcomes
- Ion Channels and Receptors
- Viral Infections and Immunology Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
University of Arizona
2014-2025
Florida International University
2021-2025
University of Montana
2013-2025
Vaccine & Gene Therapy Institute of Florida
2025
National Cancer Institute
2014-2024
Benha University
2018-2024
Dr. Herbert & Nicole Wertheim Family Foundation
2024
Royal Society of Chemistry
2023
The Ohio State University
2012-2023
Texas A&M University
2023
Design, physicochemical characterization, and optimization of organic solution advanced spray-dried inhalable dipalmitoylphosphatidylcholine (DPPC) dipalmitoylphosphatidylethanolamine poly(ethylene glycol) (DPPE-PEG) microparticles nanoparticles for targeted respiratory nanomedicine delivery as dry powder inhalation aerosols
The impact of pulmonary hypertension (PH) on survival in cystic fibrosis (CF) remains unclear.To determine the influence PH CF population.The United Network for Organ Sharing database was queried from 1987 to 2013 identify first-time lung transplant candidates who were tracked wait list entry date until death or censoring PH. Using right heart catheterization measurements, mild defined as mean artery pressure greater than equal 25 mm Hg and severe 35 Hg.Of 2,781 patients, 2,100 used...
Nanomedicine is making groundbreaking achievements in drug delivery. The versatility of nanoparticles has given rise to its use respiratory delivery that includes inhalation aerosol by the nasal route and pulmonary route. Due unique features route, research exploring for poorly absorbed systemically unstable drugs been increasing. successfully used macromolecules like proteins, peptides, vaccines, continues be examined with small molecules, DNA, siRNA, gene therapy. Phospholipid nanocarriers...
Autophagy is activated when the neonatal brain exposed to hypoxia ischemia (HI), but mechanisms underlying its activation and role in neuronal cell death associated with HI unclear. We have previously shown that reactive oxygen species (ROS) derived from nicotinamide adenine dinucleotide phosphate (NADPH) oxidase play an important HI-mediated death. Thus, aim of this study was determine if ROS involved autophagy injury a protective or deleterious pathway. Initial electron microscopy data...
The purpose was to design and characterize inhalable microparticulate/nanoparticulate dry powders of mannitol with essential particle properties for targeted powder delivery cystic fibrosis mucolytic treatment by dilute organic solution spray drying, and, in addition, tailor correlate aerosol dispersion performance delivered as inhalers based on spray-drying conditions solid-state physicochemical properties.Organic advanced drying from followed comprehensive characterization vitro...
Abstract: The aim of this study was to design and develop respirable antibiotics moxifloxacin (MOXI) hydrochloride ofloxacin (OFLX) microparticles nanoparticles, multifunctional particles with or without lung surfactant 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) for targeted dry powder inhalation delivery as a pulmonary nanomedicine. Particles were rationally designed produced by advanced spray-drying particle engineering from an organic solution in closed mode (no water) dilute...