A5007519130- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- NF-κB Signaling Pathways
- Immune cells in cancer
- Electrocatalysts for Energy Conversion
- Viral-associated cancers and disorders
- interferon and immune responses
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Catalytic Processes in Materials Science
- Inflammasome and immune disorders
- Electrochemical Analysis and Applications
- Circular RNAs in diseases
- Immune Cell Function and Interaction
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Sun Yat-sen University
2022-2024
Sun Yat-sen University Cancer Center
2022-2024
State Key Laboratory of Oncology in South China
2023
Abstract Although radiotherapy can promote antitumour immunity, the mechanisms underlying this phenomenon remain unclear. Here, we demonstrate that expression of E3 ubiquitin ligase, tumour cell-intrinsic tripartite motif-containing 21 (TRIM21) in tumours, is inversely associated with response to radiation and CD8 + T cell-mediated immunity nasopharyngeal carcinoma (NPC). Knockout TRIM21 modulates cGAS/STING cytosolic DNA sensing pathway, potentiates antigen-presenting capacity NPC cells,...
Abstract Purpose: Cisplatin-based chemotherapy effectively improves the distant-metastasis control in nasopharyngeal carcinoma (NPC), but approximately 30% of patients develop treatment failure due to chemoresistance. However, underlying mechanisms remain poorly understood. Experimental Design: Circular RNA (circRNA) sequencing data were used identify metastasis-specific circRNAs and expression circIPO7 was validated NPC tissues as well cell lines by qRT-PCR. The whole transcriptional...
Chemoresistance is a main reason for treatment failure in patients with nasopharyngeal carcinoma, but the exact regulatory mechanism underlying chemoresistance carcinoma remains to be elucidated. Here, we identify PJA1 as key E3 ubiquitin ligase involved that highly expressed nonresponse docetaxel-cisplatin-5-fluorouracil induction chemotherapy. We find facilitates docetaxel resistance by inhibiting GSDME-mediated pyroptosis cells. Mechanistically, promotes degradation of mitochondrial...
Despite that the docectaxel-cisplatin-5-fluorouracil (TPF) induction chemotherapy has greatly improved patients' survival and became first-line treatment for advanced nasopharyngeal carcinoma (NPC), not all patients could benefit from this therapy. The mechanism underlying TPF chemoresistance remains unclear. Here, by analyzing gene-expression microarray data of who received chemotherapy, we identify transcription factor ATMIN as a gene in response to NPC. Mass spectrometry Co-IP assays...