A5017952380- Cardiomyopathy and Myosin Studies
- Testicular diseases and treatments
- Cardiovascular Effects of Exercise
- Sexual Differentiation and Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Sarcoma Diagnosis and Treatment
- Cardiac Fibrosis and Remodeling
- Peptidase Inhibition and Analysis
- Cancer Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Electrochemical sensors and biosensors
- Enzyme Catalysis and Immobilization
- Neuroblastoma Research and Treatments
- Sperm and Testicular Function
- Muscle Physiology and Disorders
- Nanoplatforms for cancer theranostics
- Paranormal Experiences and Beliefs
- Graphene and Nanomaterials Applications
- Urologic and reproductive health conditions
- Ultrasound and Hyperthermia Applications
- Signaling Pathways in Disease
- HIV/AIDS Impact and Responses
- Neuroscience and Neuropharmacology Research
- Urological Disorders and Treatments
Oslo University Hospital
2013-2023
Institutt for Eksperimentell Medisinsk Forskning
2021-2023
University of Oslo
2022-2023
Norwegian University of Science and Technology
2020-2021
Aarhus University
2018
Cancer Registry of Norway
2011-2013
In-Q-Tel
2011
To improve therapeutic efficacy of nanocarrier drug delivery systems, it is essential to their uptake and penetration in tumour tissue, enhance cellular ensure efficient release at the site. Here we introduce a targeting system based on ultrasound-mediated enzyme sensitive liposomes. These liposomes are coated with cleavable poly(ethylene glycol) (PEG) which will be cleaved by two members matrix metalloproteinase family (MMP-2 MMP-9). Cleavage PEG coat can increase destabilize liposomal...
Familial hypertrophic cardiomyopathy (HCM) is the most common form of inherited cardiac disease. It characterized by myocardial hypertrophy and diastolic dysfunction, can lead to severe heart failure, arrhythmias, sudden death. Cardiac fibrosis, defined excessive accumulation extracellular matrix (ECM) components, central pathophysiology HCM. The ECM proteoglycan lumican increased during failure including HCM, yet its role in HCM remains unknown. We provide an in-depth assessment clinical...
The purpose of the study was to identify overall incidence and risk developing a metachronous contralateral testicular germ cell tumor (TGCT) compare for patients treated before after 1980 (cisplatin became available with metastatic TGCT). Our hypothesis that TCGT would be reduced disease diagnosed 1980. We included 7,102 men unilateral TGCT, recorded in Cancer Registry Norway. Allowing competing risk, cumulative adjusted hazard ratio (HR) were estimated different subgroups, diagnostic...
Abstract MicroRNA-371a-3p (miR371) has been suggested as a sensitive biomarker in testicular germ cell cancer (TGCC). We aimed to compare miR371 with the classical biomarkers α-fetoprotein (AFP) and β-human chorionic gonadotropin (hCG β ). Overall, 180 patients were prospectively enrolled study, serum samples collected before after orchiectomy. compared use of digital droplet PCR (RT-ddPCR) quantitative used by others for detection miR371. The novel RT-ddPCR protocol showed high performance...
Recent genome-wide association studies have identified single-nucleotide polymorphisms (SNPs) associated with testicular germ cell tumor (TGCT) risk in the genes ATF7IP, BAK1, DMRT1, KITLG, SPRY4 and TERT. In present study, we validate these associations a Scandinavian population, explore effect modification by parental sex differences between major histological subtypes seminoma non-seminoma. A total of 118 SNPs six were genotyped population-based Swedish-Norwegian sample comprising 831...
STUDY QUESTIONIs there an association between testicular germ cell tumor (TGCT) and genetic polymorphisms in AKT1, PTEN the 8q24 locus?
Cell mimicry aims to create artificial structures capable of mimicking certain functions living cells. However, cell mimics are tremendously simpler than their natural role models. Thus, increasing complexity is great importance for the advancement concepts and further understanding biological intracellular processes. Here, successful co-encapsulation two enzymatic pathways with up five enzymes into compartmentalized microreactors reported. The assembled by combining polymer layers...
Diastolic dysfunction is an important part of the clinical phenotype in hypertrophic cardiomyopathy (HCM). While exercise training known to improve left ventricular (LV) diastolic function normal hearts, effects during childhood and adolescence carriers HCM-associated genetic variants are unknown.In a cross-sectional retrospective study, we combined echocardiographic data with history from time examination 187 participants HCM or HCM-causative genotype. Multiple linear regression was used...
BACKGROUNDTesticular germ cell tumour (TGCT) is the most common cancer in young men, and an imbalance between estrogen androgen levels utero hypothesized to influence TGCT risk. Thus, polymorphisms genes involved action of sex hormones may contribute variability individual's susceptibility TGCT.
Abstract Heart failure is a major cause of morbidity and mortality worldwide, can result from pressure overload, where cardiac remodelling characterized by cardiomyocyte hypertrophy death, fibrosis, inflammation. In failing hearts, transforming growth factor (TGF)β drives fibroblast (CFB) to myofibroblast differentiation causing excessive extracellular matrix production remodelling. New strategies target pathological TGFβ signalling in heart are needed. Here we show that the secreted...
Genotype-positive hypertrophic cardiomyopathy (HCM) mice had beneficial effects of exercise initiated before phenotype development. Exercised HCM increased capacity, smaller left atria, no increase in hypertrophy, or reduction function, and a similar degree fibrosis despite central extracellular matrix (ECM) genes, including collagens, compared with sedentary mice.
Abstract Background There is strong evidence that genetic variation influences the risk of testicular germ cell tumor (TGCT). The oncogene AKT1, suppressor gene PTEN and 8q24 locus play important roles in cancer development, investigation their role TGCT warranted. Methods We investigated association between AKT1 genes, a Norwegian-Swedish case-parent study. included 831 triads, 474 dyads 712 singletons, 26 single nucleotide polymorphisms (SNPs) were genotyped. First, triads likelihood-based...
Abstract BACKGROUND: Testicular germ cell tumor (TGCT) is the most common malignancy in young men. Genetic components and conditions during pregnancy are known to play an etiologic role. Recent genome-wide association studies have identified single nucleotide polymorphisms (SNPs) associated with TGCT risk genes ATF7IP, BAK1, DMRT1, KITLG, SPRY4, TERT. In present study we validate these associations a Scandinavian population, explore effect modification by parental sex differences between two...
1579 Background: The aims were to identify the overall incidence and risk of developing a met-TGCT, compare between patients treated before after 1980 (cisplatinum-based chemotherapy became available for newly diagnosed TGCT in Norway). Our hypothesis was that TCGT would be reduced 1980, at least subgroups patients, due protective effect cisplatinum. Methods: study included 7,248 men with unilateral (seminoma: 3,999, nonseminoma: 3,249) recorded Cancer Registry Norway. Allowing competing...
Event Abstract Back to Organic and inorganic-based microreactors as a therapeutic approach against excitotoxicity. Adam Armada-Moreira1, 2, 3, Essi Taipaleenmaki3, Marie Baekgaard-Laursen3, Philipp S. Schattling3, Bo Thingholm3, Kristine Andreassen3, Ana M. Sebastião1, Brigitte Stadler3 Sandra H. Vaz1, 2* 1 Institute of Pharmacology Neurosciences, Faculty Medicine, University Lisbon, Portugal 2 Faculdade de Medicina, Universidade Lisboa, 3 Interdisciplinary Nanoscience Centre, Science...
INTRODUCTION AND OBJECTIVE: Post-chemotherapy retroperitoneal lymph node dissection (PC-RPLND) in patients with metastatic non-seminoma germ cell tumour (NSGCT) is a procedure high complication rate and risk of permanent retrograde ejaculation. The current Swedish Norwegian Testicular Cancer Group (SWENOTECA) modified unilateral template results low rate, but relatively proportion experiences objective was to evaluate the histology resected nodes specific areas outcome patients, identify...