A5042761328- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- RNA Interference and Gene Delivery
- Micro and Nano Robotics
- Tissue Engineering and Regenerative Medicine
- Molecular Communication and Nanonetworks
- Photodynamic Therapy Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Autophagy in Disease and Therapy
- Microtubule and mitosis dynamics
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Chemical Reactions and Isotopes
- Virus-based gene therapy research
- Neonatal Respiratory Health Research
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Sex work and related issues
- Phonetics and Phonology Research
- Immunotherapy and Immune Responses
- Microfluidic and Bio-sensing Technologies
- Phagocytosis and Immune Regulation
Sichuan University
2020-2024
Zhejiang University
2021-2024
Shenzhen University
2024
Hubei University of Science and Technology
2018
The transfer of mitochondria between cells has recently been revealed as a spontaneous way to protect the injured cells. However, utilization this natural process for disease treatment is so far limited by its unsatisfactory efficiency and selectivity. Here, we demonstrate that iron oxide nanoparticles (IONPs) can augment intercellular mitochondrial from human mesenchymal stem (hMSCs) selectively diseased cells, owing enhanced formation connexin 43–containing gap junctional channels...
The use of exogenous mitochondria to replenish damaged has been proposed as a strategy for the treatment pulmonary fibrosis. However, success this is partially restricted by difficulty supplying sufficient diseased cells. Herein, we report generation high-powered mesenchymal stem cells with promoted mitochondrial biogenesis and facilitated transfer injured lung sequential pioglitazone iron oxide nanoparticles. This highly efficient shown not only restore homeostasis but also reactivate...
Tumor vaccine is a promising cancer treatment modality, however, the convenient antigens loading in vivo and efficient delivery of vaccines to lymph nodes (LNs) still remain formidable challenge. Herein, an situ nanovaccine strategy targeting LNs induce powerful antitumor immune responses by converting primary tumor into whole-cell then delivering these nanoadjuvants simultaneously proposed. The based on hydrogel system, which loaded with doxorubicin (DOX) nanoadjuvant CpG-P-ss-M. gel system...
Abstract Homogeneous distribution and adequate accumulation of photosensitizer in tumor are essential for effective photodynamic therapy (PDT). However, the intricate microenvironment (TME) often poses great challenges to deep penetration retention therapeutic agents tumor. Moreover, important effect PDT induce specific antitumor immune response is impeded by multiple immunosuppressive mechanisms within TME. Confronting these issues, here a rationally designed nanosystem (SUN‐NPA) with...
Mesenchymal stem cells (MSCs) and their produced exosomes have demonstrated inherent capabilities of inflammation-guided targeting inflammatory modulation, inspiring potential applications as biologic agents for treatments. However, the clinical cell therapies are currently restricted by several challenges, one them is mass production to satisfy therapeutic demands in bench. Herein, a human amnion-derived MSCs (hMSCs) at scale over 1 × 10
Background: Mesenchymal stem cells (MSCs) have been applied as a promising vehicle for tumour-targeted delivery of suicide genes in the herpes simplex virus thymidine kinase (HSV-tk)/ganciclovir (GCV) gene therapy against malignant gliomas.The efficiency this strategy is largely dependent on bystander effect, which relies high expression levels and efficient transportation activated GCV towards glioma cells.However, up to now, methods enhance effect an safe way are still lacking new...
Abstract Pulmonary inflammation is one of the most reported tissue inflammations in clinic. Successful suppression vital to prevent further inevitably fatal lung degeneration. Glucocorticoid hormone, such as methylprednisolone (MP), applied strategy control inflammatory progression yet faces challenge systemic side effects caused by requirement large‐dosage and frequent administration. Highly efficient delivery MP specifically targeted sites may overcome this challenge. Therefore, present...
Abstract The hybridization of liposome with stem cell membranes is an emerging technology to prepare the nanovehicle capacity disease‐responsive targeting. However, long‐term storage this hybrid has received limited attention in literature, which essential for its potential applicability clinic. Therefore, preservation activity cell‐hybrid using freeze‐drying investigated present study. Mesenchymal synthesized and feasibility under different conditions examined. Results reveal that...
College students in China are emerging as one of the most vulnerable groups to contract HIV, because they a sexually active age group and also their open attitude toward sex high risk sexual behaviors. This study aimed explore prevalence willingness among college utilize HIV testing counseling (HTC) service factors that may affect willingness, including predisposing, enabling need factors, based on Andersen's behavioral model.A cross-sectional was conducted from October 6, 2016 December 31,...
English pronunciation can vary significantly depending on different speakers' accents. In one of Chinese dialects, Cantonese-speaking regions, where Cantonese has led to properties in communicative and teaching activities. To address this situation, research conducted an e
Mesenchymal Stem Cell-Hybrid Nanovehicles In article 2300376, Donghang Xu, Tianyuan Zhang, Jianqing Gao and co-workers develop a biomimetic nanovehicle hybridizing the cell membrane of mesenchymal stem with liposome. This hybrid shows advantages both highly efficient inflammation targeting good drug-loading capacity, resulting in specifically targeted delivery methylprednisolone to inflammatory damaged lung cells. A single-dose administration this achieves prominent suppression, showing...