A5052115857- Wound Healing and Treatments
- Congenital Diaphragmatic Hernia Studies
- Electrospun Nanofibers in Biomedical Applications
- Hernia repair and management
- Advanced Nanomaterials in Catalysis
- Esophageal and GI Pathology
- Mesenchymal stem cell research
- Extracellular vesicles in disease
- Congenital gastrointestinal and neural anomalies
- Appendicitis Diagnosis and Management
- Gastrointestinal disorders and treatments
- Silk-based biomaterials and applications
- Tracheal and airway disorders
- Diabetic Foot Ulcer Assessment and Management
- Congenital Anomalies and Fetal Surgery
- Abdominal Surgery and Complications
- Neonatal Respiratory Health Research
- Prenatal Substance Exposure Effects
- Spinal Dysraphism and Malformations
- Pressure Ulcer Prevention and Management
- Inflammatory Biomarkers in Disease Prognosis
- Teratomas and Epidermoid Cysts
- Foreign Body Medical Cases
- Immune cells in cancer
- Cardiac Structural Anomalies and Repair
Children's Hospital Colorado
2020-2024
University of Colorado Denver
2020-2024
University of Colorado Anschutz Medical Campus
2020-2022
University of Colorado System
2022
University of Minnesota Rochester
2021
Colorado School of Mines
2020
University of Minnesota Medical Center
2017-2019
University of Minnesota
2017
Acute respiratory distress syndrome (ARDS) is a devastating pulmonary disease with significant in-hospital mortality and the leading cause of death in COVID-19 patients. Excessive leukocyte recruitment, unregulated inflammation, resultant fibrosis contribute to poor ARDS outcomes. Nanoparticle technology cerium oxide nanoparticles (CNP) offers mechanism by which unstable therapeutics such as anti-inflammatory microRNA-146a can be locally delivered injured lung without systemic uptake. In...
Diabetes mellitus is a metabolic disorder associated with properties and an increased risk of chronic wounds due to sustained pro-inflammatory response. We have previously radical scavenging cerium oxide nanoparticles (CNP) conjugated the anti-inflammatory microRNA (miR)-146a, termed CNP-miR146a, improves diabetic wound healing by synergistically lowering oxidative stress inflammation, we sought evaluate this treatment in topical application. Silk fibroin biocompatible polymer that can be...
Amplex red infused silk mats in visible detection of oxidative stress the cutaneous wound over time.
Introduction Accidental ingestion of foreign bodies is an increasing problem in the pediatric population. Symptoms are often nonspecific and may lead to a missed diagnosis because event goes unwitnessed. Case We present case multiple magnet patient leading operative management. A 2-year-old boy with 4-week history abdominal pain presented emergency department (ED) vomiting worsening pain. He was recently seen ED for diagnosed as acute otitis media. In this second visit, child found be...
Hyperparathyroidism (HPT) is a rare disease in the pediatric population, and optimal management may be unclear if it due to an occult parathyroid adenoma. We present case report of patient with occult, ectopic, supernumerary, adenoma.A 13-year-old female who initially presented anxiety was diagnosed HPT. Preoperative imaging bilateral neck exploration four-gland biopsy were negative for any Postoperative MRI identified thymic mass. She subsequently underwent video-assisted thoracoscopic...
Skin aging is an inevitable process with one of the key features being dryness or flakiness skin. Previous in vivo and vitro testing has highlighted that a silk-based product may be effective improving moisture retention skin.We evaluated safety efficacy our through combination objective- including scanning electron microscopy (SEM) EpiDerm Irritation tests - subjective direct evaluation patient's own perception their skin.In alignment previous studies, patients reported significant concerns...
<title>Abstract</title> Purpose Hospital length of stay (LOS) following admission for appendicitis is difficult to predict. Shock index, pediatric age adjusted (SIPA) accurately identifies severely injured trauma patients and predicts mortality among children admitted the ICU. Our aim was determine if elevated SIPA at presentation, time normalization SIPA, can identify with perforated predict hospital LOS. Methods This a retrospective cohort study 1–17 years quaternary care referral center...
Introduction: Neurofibromatosis type 1 (NF1) is the most commonly inherited autosomal dominant disorder in humans. NF1 patients have increased risk for gastrointestinal stromal tumors (GISTs). A Meckel’s diverticulum (MD) represents a persistent embryonic omphalomesenteric duct characterized as true located near ileocecal valve. We report unique clinical case whereby patient with developed GIST within MD. Case: An adolescent male presented lower abdominal pain. Clinical evaluation...
Abstract Background For infants with severe congenital diaphragmatic hernia (CDH) stabilized extracorporeal membrane oxygenation (ECMO), early repair on ECMO improves outcome; however when compared to operative after ECMO, is associated increase bleeding risk and need for blood product transfusions. Methods A retrospective review of 54 patients CDH placed prior was performed. the subset repaired analysis comparing those (within 48 h cannulation) late (beyond h) Outcomes interest included...
Abstract Acute respiratory distress syndrome (ARDS) is a devastating pulmonary disease with significant inhospital mortality and the leading cause of death in COVID-19 patients. Potential therapies remain limited despite advancements understanding ARDS pathophysiology. Excessive leukocyte recruitment, unregulated inflammation, resultant fibrosis contribute to poor outcomes. In this study, we evaluated potential radical scavenging cerium oxide nanoparticle (CNP) conjugated anti-inflammatory...