A5015882197- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
- Mycobacterium research and diagnosis
- Leprosy Research and Treatment
- Receptor Mechanisms and Signaling
- Neurobiology and Insect Physiology Research
- Advanced Chemical Sensor Technologies
- Polyamine Metabolism and Applications
- Hepatitis Viruses Studies and Epidemiology
- Antimicrobial Peptides and Activities
- Dermatology and Skin Diseases
- PARP inhibition in cancer therapy
- Viral gastroenteritis research and epidemiology
- Tuberculosis Research and Epidemiology
- Regulation of Appetite and Obesity
- Amino Acid Enzymes and Metabolism
- Liver Disease and Transplantation
- Immune Response and Inflammation
- Yersinia bacterium, plague, ectoparasites research
Leibniz-Institute for Food Systems Biology at the Technical University of Munich
2016-2023
Technical University of Munich
2018
University of Tübingen
2013-2016
With approximately 400 encoding genes in humans, odorant receptors (ORs) are the largest subfamily of class A G protein-coupled (GPCRs). Despite its high relevance and representation, odorant-GPCRome is structurally poorly characterized: no experimental structures available, low sequence identity ORs to experimentally solved GPCRs a significant challenge for their modeling. Moreover, receptive range most unknown. The receptor OR5K1 was recently comprehensively characterized terms cognate...
In recent years, genome wide association studies have discovered a large number of gene loci that play functional role in innate and adaptive immune pathways associated with leprosy susceptibility. The immunological control intracellular bacteria M. leprae is modulated by NOD2-mediated signaling Th1 responses. this study, we investigated 211 clinically classified patients 230 ethnically matched controls Indian population genotyping four variants NOD2 (rs9302752A/G), LRRK2 (rs1873613A/G),...
Molecular recognition is a fundamental principle in biological systems. The olfactory detection of both food and predators via ecological relevant odorant cues are abilities eminent evolutionary significance for many species. Pyrazines such volatile cues, some which act as human-centered key odorants (KFOs) semiochemicals. A pyrazine-selective receptor has been elusive. Here we screened 2,3,5-trimethylpyrazine, KFO semiochemical, 2,5-dihydro-2,4,5-trimethylthiazoline, an innate...
Nasal colonization has gained attention as an effect modifier in Staphylococcus aureus vaccine trials, suggesting interference of carriage with T-cell immunity. Likewise, signals may be involved regulating effectors epithelial innate defense. Whole blood from 43 persistent carriers and 49 noncarriers was stimulated viable S. T-helper type 1 (Th1), Th2, Th17 cytokine expression measured, compared between carrier groups, linked data on human β-defensin 3 (hBD-3) messenger RNA (mRNA) skin while...
Background: Non-nutritive sweeteners (NNS) are part of personalized nutrition strategies supporting healthy glycemic control. In contrast, the consumption non-nutritive has been related to person-specific and microbiome-dependent impairments. Reports on effects NNS our highly individual cellular immune system sparse. The recent identification taste receptor expression in a variety cells, however, suggested their immune-modulatory relevance. Methods: We studied influence beverage-typical...
ABSTRACT With approximately 400 encoding genes in humans, odorant receptors (ORs) are the largest subfamily of class A G protein-coupled (GPCRs). Despite its high relevance and representation, odorant-GPCRome is structurally poorly characterized: no experimental structures available, low sequence identity ORs to experimentally solved GPCRs a significant challenge for their modeling. Moreover, receptive range most unknown. The receptor OR5K1 was recently comprehensively characterized terms...