Vascular endothelial growth factor (VEGF) regulates cell proliferation, migration and differentiation. VEGF plays a critical role in angiogenesis during placenta formation. We investigated whether gene polymorphisms are associated with recurrent pregnancy loss. Thirty-eight women loss 30 control live-born children were recruited from 2010 to 2011 the region of Bursa, Turkey. assessed PCR-RFLP analysis DNA samples obtained leukocytes. fragments by using appropriate primers. SNP scanning was...

Long non‑coding RNAs (lncRNAs) are molecules that &gt;200 base pairs long and do not encode a protein. However, they perform important roles in regulating gene expression. Recent studies have revealed the changes expressions of lncRNAs serve role development metastases number types cancer. A been published on association SOX2 overlapping transcript (<em>SOX2OT</em>), differentiation antagonizing non‑protein coding RNA (<em>DANCR</em>) tissue differentiation‑induced (<em>TINCR</em>)...

Introduction: Polymorphisms in FGFR2 are important markers for breast cancer susceptibility the general population. CHEK2 and polymorphisms with known alleles of BRCA1, BRCA2, PTEN, TP53, can be investigated as potential modifiers high penetrant risk alleles. Although B7-H4 gene is highly expressed many different tumors, there one published study showing association cancer. We aimed to investigate Turkish community. Materials Methods: In a group 31 cases diagnosed 30 healthy women matched...

Drug resistance poses a crucial problem in the treatment of prostate cancer. Recent studies have shown that chemotherapy agents may cause cancer cells to acquire stem cell-like properties, resulting drug and, eventually, failure.To evaluate whether long-term paclitaxel exposure causes an increase properties cells.Paclitaxel-resistant PC-3 were generated from parental by treating them with increasing concentrations paclitaxel. The expression levels cell markers NANOG, C-MYC, CD44, and ABCG2...

We report on the clinical and molecular findings of a patient who presented alopecia, epicanthus, micrognathia, retrognathia, high arched palate, hypertelorism, Chiari type I malformation, mixedtype hearing loss but with normal heartbeat Q-T interval, malformed earlobes, down-slanted palpebral fissures, downturned corners mouth, syndactyly, atopic eczema, seizures.The was male adult, 23 years old, short stature (153 cm) low weight (50.5 kg), due to severe aortic insufficiency dilatation...

Background/aim: We aimed to study polymorphisms of the B7-H4 gene in order evaluate a possible association urothelial carcinoma, as it is highly expressed cancer tissues. Materials and methods: In this rs10754339, rs10801935, rs3738414 SNPs were studied by PCR-RFLP method paraffin-embedded tumor specimens from 62 carcinoma patients control group including 30 without bladder cancer. Results: detected that rs10754339 polymorphism was more frequent when compared with (P < 0.05). Only showed...

Long noncoding RNAs (lncRNAs) play an important role in regulating gene expression. Changes their expression have been associated with many types of cancer, including thyroid cancer. This study aimed to investigate how changes the potassium voltage-gated channel subfamily Q member 1 opposite strand/antisense transcript (KCNQ1OT1) and HAGLR strand lncRNA (HAGLROS) lncRNAs correlate development clinicopathological characteristics papillary cancer (PTC). Reverse transcription-quantitative...

Amaç:

Objective: The most common malignancy in women is breast cancer worldwide. Previous studies performed different populations have suggested an association between Multi-Drug Resistance (MDR1) gene polymorphisms and risk women. purpose of the current study to examine relationship MDR1 (C3435T, G2677T/A, C1236T, A2956G) Turkish women.Methods: In this 35 cases 20 healthy controls were enrolled. Identification genotypes was with polymerase chain reaction/restriction fragment length polymorphism...

Obesity is one of the most important health risks in postmenopausal women. Molecular pathways that are connected with obesity believed to interact pathogenesis breast cancer (BC). The aim this research was study polymorphisms two obesity-associated genes ADIPOQ and FTO also related BC. Obesity-associated gene rs1501299 rs2241766, rs1477196, rs7206790, rs8047395, rs9939609 were studied 101 Turkish estrogen receptor-positive BC patients 100 healthy control individuals. detected be associated...

Visfatin is a novel adipocytokine, which suggested to play role in kidney diseases. We hypothesized that diabetics with diabetic nephropathy may have different gene profile and this study was performed evaluate the association between visfatin promoter region SNPs nephropathy. Realtime PCR used (1001T/G, 423A/G, 1535C/T) of 30 type 2 nephropathy, without healthy volunteers who served as control. Routine biochemical parameters, serum insulin, TNF-α, urinary protein microalbumine were tested...

p53 geni, insan malignitelerinin yaklasik %50’sinde mutasyona ugrayan bir tumor supresor gendir. mesane kanserinde en fazla geni olma ozelligini tasimaktadir. Bu yuzden kanserinin prognozunun belirlenmesinde onemli biomarker olabilir. arastirmada, kanseri teshisi konmus 22 olguya ait doku orneklerinden DNA izole edilip, PCR metoduyla 5. ve 7. ekson bolgeleri amplifiye edildikten sonra, enzim kesimi yapilarak eksonlarda mutasyon analizi gerceklestirilmistir. Mutasyon gerceklestirilen...

Abstract Objectives This study aimed to examine the role of miR-221, miR-650, and miR-4534 expressions in development, pathogenesis, early diagnosis prostate cancer. Methods The included 83 participants: 37 patients with PCa, 31 BPH, 15 healthy subjects. MiRNA plasma samples was evaluated by quantitative RT-PCR. Results Plasma miR-221 levels were significantly upregulated PCa BPH groups compared control group. A significant difference determined between presence lymph node metastasis miRNAs....

Amaç: ERK 1/2 (ekstraselüler sinyalle düzenlenen kinaz 1, 2) ve p38α’nın, FGFR1 Ser 777’yi fosforile etmek yoluyla anti-tümörojenik etki göstermesi muhtemeldir. Ser777 fosforilasyonunun ise aktivasyonunu inhibe ettiği bilinmektedir. Dolayısıyla Ser777’nin mutasyona uğramasının FGFR1’i aktive ederek; karsinogenez ile bunu devam ettirebilecek mekanizmaları harekete geçirebileceği düşünülmüştür. Bu kapsamda gerçekleştiren çalışmada; mesane kanseri mutasyonu arasındaki ilişkinin tespiti...