A5033915682- Autopsy Techniques and Outcomes
- Healthcare cost, quality, practices
- Amphibian and Reptile Biology
- Pain Mechanisms and Treatments
- Rabies epidemiology and control
- Wildlife Ecology and Conservation
- Mobile Health and mHealth Applications
- Digital Mental Health Interventions
- Healthcare Policy and Management
- Sarcoidosis and Beryllium Toxicity Research
- Antifungal resistance and susceptibility
- Medical Coding and Health Information
- Neuroendocrine Tumor Research Advances
- Patient-Provider Communication in Healthcare
- Mosquito-borne diseases and control
- Syphilis Diagnosis and Treatment
- Streptococcal Infections and Treatments
- Neuroblastoma Research and Treatments
- Radiology practices and education
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Literacy and Information Accessibility
- Vascular Anomalies and Treatments
- Venomous Animal Envenomation and Studies
- Abdominal vascular conditions and treatments
- Congenital Heart Disease Studies
Community Care Partners
2018-2020
Johns Hopkins University
2012-2019
Johns Hopkins Hospital
2014-2019
Sheffield Teaching Hospitals NHS Foundation Trust
2019
Johns Hopkins Medicine
2014-2018
Baylor University Medical Center
2004-2011
University of Tennessee at Knoxville
2007-2009
Louisiana Department of Wildlife and Fisheries
2007-2009
University of Ottawa
2008
Baylor Scott & White Health
2008
In 2004, four recipients of kidneys, a liver, and an arterial segment from common organ donor died encephalitis unknown cause.We reviewed the medical records recipients. Blood, cerebrospinal fluid, tissues were tested with variety assays pathological stains for numerous causes encephalitis. Samples also inoculated into mice.The had been healthy before having subarachnoid hemorrhage that led to his death. Encephalitis developed in all within 30 days after transplantation was accompanied by...
We previously reported (Bell, D., P. Chomarat, D. Broyles, G. Netto, G.M. Harb, S. Lebecque, J. Valladeau, Davoust, K.A. Palucka, and Banchereau. 1999. Exp. Med. 190: 1417–1426) that breast cancer tumors are infiltrated with mature dendritic cells (DCs), which cluster CD4+ T cells. now show infiltrating secrete type 1 (interferon γ) as well high levels of 2 (interleukin [IL] 4 IL-13) cytokines. Immunofluorescence staining tissue sections revealed intense IL-13 on The expression...
We've all heard about cases in which a patient presumed to have died from acute myocardial infarction was discovered at autopsy had an aortic dissection, or who presented with decompensated liver failure alcoholic cirrhosis but proved widely metastatic hepatocellular carcinoma. Indeed, extensive literature documents the frequency reveals clinically significant diagnoses that were missed before death.1 Autopsies also generate more accurate vital statistics, provide pathological descriptions...
Article abstract-Nerve growth factor (NGF) plays a biologic role in the development and maintenance of sympathetic small sensory neurons. Because it facilitates nerve fiber regeneration, lowers heat-pain threshold (hyperalgesia), prevents or improves dysfunction experimental neuropathy, is being considered as putative treatment for certain human polyneuropathies. In 16 healthy subjects, we tested whether intradermal injection minute doses recombinant NGF (1 3 micro g) compared with saline...
The human breast tumor microenvironment can display features of T helper type 2 (Th2) inflammation, and Th2 inflammation promote development. However, the molecular cellular mechanisms contributing to in tumors remain unclear. Here, we show that cancer cells produce thymic stromal lymphopoietin (TSLP). Breast supernatants, a TSLP-dependent manner, induce expression OX40L on dendritic (DCs). OX40L+ DCs are found primary infiltrates. drive development inflammatory producing interleukin-13...
Autopsy often reveals new diagnoses of malignant neoplasms, but as technological advances to improve diagnosis during life have improved, autopsy rates declined dramatically.To determine if there is still a high discordance rate between clinical and neoplasms despite increasing in diagnostic methods.A 10-year retrospective study (1986-1995) all autopsies performed at the Medical Center Louisiana New Orleans.All patients autopsied, excluding preterm fetuses, Orleans, by both Tulane State...
Summary Agricultural practices such as cattle farming may have direct or indirect negative effects on larval amphibians by decreasing water quality through deposition of nitrogenous waste, causing eutrophication, and grazing shoreline vegetation that contributes to detrital cover food. We sampled amphibian larvae the Cumberland Plateau, Tennessee, U.S.A., twice per week, month algal biomass once at seven wetlands (three cattle‐access four non‐access) from March August 2005 2006. In general,...
Three patients received solid organ transplants from a common donor and were subsequently discharged the hospital following an uneventful course. Within 30 days, all 3 recipients returned to with varying symptoms that progressed rapid neurological deterioration, coma, death.To describe clinical, neuroradiological, pathological findings of rabies virus infection in transplant infected donor.Case series involving ascertained through review clinical course autopsy findings. A fourth case was...
ABSTRACT Global amphibian declines have been linked to various anthropogenic land uses. Recent studies documented negative impacts of cropland agriculture and deforestation on amphibians; however, few examined potential cattle grazing in wetlands resident amphibians. Therefore, we measured differences number captures body size postmetamorphic amphibians, egg mass abundance, shoreline vegetation structure composition between 4 with direct access from which were excluded the Cumberland Plateau...
This case report describes a patient who underwent orthotopic liver transplantation and developed extensive hyperacute venous arterial intravascular thromboses thromboemboli intraoperatively. The was receiving antifibrinolytic therapy with aprotinin. safety of routine aprotinin in is examined. value the thrombelastograph (TEG) as qualitative assessment coagulation system emphasized.
Diagnostic sensitivity is calculated as the number of correct diagnoses divided by sum plus missed or false negative diagnoses. Because are generally detected during clinical follow up at necropsy, low necropsy rates seen in current practice may result overestimates diagnostic performance. Using three target conditions (aortic dissection, pulmonary embolism, and active tuberculosis), prevalence clinically cases among necropsied non-necropsied deaths was estimated impact on apparent...
Heterotaxy is a rare disease with high morbidity and mortality. Controversy exists over how to classify these syndromes most cases stratified into asplenia/polysplenia or right/left isomerism. In an effort review comprehensively specific pheonotypes associated heterotaxy syndromes, we reviewed published series, adopted classification scheme based on spleen status, evaluated autopsy retrospectively abnormal laterality at our institution. We categorized 116 as situs inversus totalis,...
Amphibian populations are declining globally, yet general pathologic surveys for free-ranging amphibians uncommon. Pathologic necessary to provide insight into the impacts of humans on emergence pathogens in amphibian populations. During 2005, 104 American bullfrog (Rana catesbeiana) and 80 green frog clamitans) larvae 40 juveniles were collected from farm ponds Tennessee, complete necropsies performed. Diagnostic testing included bacterial culture, virus testing, fecal parasite analysis,...
Background: Asthma is a highly prevalent, chronic disease with significant morbidity, cost, and disparities in health outcomes. While adherence to asthma treatment guidelines can improve symptoms decrease exacerbations, most patients receive care that not guideline-based. New approaches incorporate shared decision-making (SDM) information technology (IT) are needed positively impact management. Despite the promise of IT efficiency outcomes care, new solutions frequently suffer from lack...
Forty years ago, the value of autopsies was widely recognized as new diseases were discovered or clarified and scientific technology advanced greatly. Despite autopsy's strong foundation, its is not currently being properly conveyed to physicians patients. Although autopsy-related policy exists, these policies have had little effect on increasing even maintaining adequate autopsy rates. More recently, has fallen hard times, with US hospital rates now below 5%. The reasons for decline in are...
The long-term use of proton pump inhibitors has been linked to an increased risk for the development gastric polyps, hip fractures, pneumonia, and Clostridium difficile colitis. There is evidence that chronic acid suppression from poses some C difficile-associated diarrhea by decreasing elimination pathogenic microbes before reaching lower gastrointestinal tract. Here we present a case 51-year-old woman with recent history abdominal pain fever who presented emergency department rapidly...
We orally inoculated Rana catesbeiana tadpoles (n=23) and metamorphs (n=24) to test their suitability as hosts for Escherichia coli O157:H7. Tadpoles were housed in flowthrough aquaria did not become infected. Metamorphs stagnant aquaria, 54% tested positive through 14 days postinoculation, suggesting that they are suitable E.