A5021449278- Inflammatory Bowel Disease
- Tuberculosis Research and Epidemiology
- Atherosclerosis and Cardiovascular Diseases
- Protein Tyrosine Phosphatases
- Diabetes and associated disorders
- Immunodeficiency and Autoimmune Disorders
- Nitric Oxide and Endothelin Effects
- Immune Response and Inflammation
- NF-κB Signaling Pathways
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Drug Transport and Resistance Mechanisms
- Eosinophilic Esophagitis
- Chronic Lymphocytic Leukemia Research
University of Boumerdes
2020
University of Sciences and Technology Houari Boumediene
2012-2017
University of Algiers Benyoucef Benkhedda
2012-2017
Colitis associated cancer (CAC) is the colorectal (CRC) subtype that with bowel disease such as ulcerative colitis (UC). The data on role of NF-κB signaling in development and progression CAC were derived from preclinical studies, whereas human are rare. aim this work was to study contribution pathway during UC CAC, well immunomodulatory effect all-trans retinoic acid (AtRA). We analyzed expression NOS2, TNF-α, TLR4, NF-κB, colonic mucosa. also studied NO/TNF-α modulation by LPS mucosa...
We evaluated allelic frequency of NOD2 variants among 132 inflammatory bowel disease (IBD) patients and 114 unrelated healthy subjects from Algeria.Despite the fact that mutant alleles is in range found most European populations, we failed to demonstrate association these with IBD susceptibility.This might be due non exposure carriers environmental factors, required for expression disease.We can expect coming years see an increased incidence associated spread Western lifestyle this region.
Nasopharyngeal carcinoma (NPC) is thought to arise because of chronic inflammation. The correlation between nitric oxide (NO) production, a biomarker inflammation and NPC development remains unexplored. To investigate this question, we performed profile analysis on plasma collected from untreated, treated, remissive, cured relapsing patients. Nitrites were measured assess NO activity. We observed that increased nitrites concentrations in untreated patients associated with tumor development....
Event Abstract Back to PTPN22 GENE POLYMORPHISM IN CROHN DISEASE, A TYPE 1DIABET MELLITUS AND HEALTHY ALGERIAN COHORT AZIZA A. BOUKERCHA1* 1 university of science and technology houari boumediene, Algeria Introduction Protein tyrosine phosphatase, non-receptor type 22 (PTPN22) is an inhibitor T cell activation. This enzyme involved in several signalling pathways associated with the immune response. The R620W variant gene (C1858T polymorphism) has been autoimmune disorders, including...
Background: Chronic Inflammatory Bowel Diseases (IBD) including Crohn's disease (CD) and ulcerative colitis (UC) are gastrointestinal disorders under the influence of a complex genetic basis. One hundred sixty-three predisposition loci were identified by genome-wide association (GWAS) studies, refocusing pathogenesis IBD on immunity genes. Autophagy is fundamental mechanism in maintenance intestinal homeostasis. Failures this appear to be major risk factor setting up chronic inflammation....