A5100657640- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Acute Ischemic Stroke Management
- Neutropenia and Cancer Infections
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Venous Thromboembolism Diagnosis and Management
- Thermal Expansion and Ionic Conductivity
- Neurological Disorders and Treatments
- Chronic Lymphocytic Leukemia Research
- Microwave Dielectric Ceramics Synthesis
- Vitamin C and Antioxidants Research
- Vitamin D Research Studies
- Antifungal resistance and susceptibility
- Intracerebral and Subarachnoid Hemorrhage Research
- Inflammatory Biomarkers in Disease Prognosis
- Hematological disorders and diagnostics
- Multiple Myeloma Research and Treatments
- Hematopoietic Stem Cell Transplantation
- Thermodynamic and Structural Properties of Metals and Alloys
- CAR-T cell therapy research
- Fungal Infections and Studies
- Retinoids in leukemia and cellular processes
- Infectious Diseases and Tuberculosis
- Tryptophan and brain disorders
Affiliated Eye Hospital of Wenzhou Medical College
2023-2025
Wenzhou Medical University
2017-2025
Xinjiang Medical University
2024-2025
First Affiliated Hospital of Wenzhou Medical University
2017-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Institute of Hematology & Blood Diseases Hospital
2015-2024
Sixth Affiliated Hospital of Xinjiang Medical University
2024
Hangzhou Normal University
2024
Dalian University of Technology
2024
Shandong University
2023
Abstract Single-cell multi-omics (scMulti-omics) allows the quantification of multiple modalities simultaneously to capture intricacy complex molecular mechanisms and cellular heterogeneity. Existing tools cannot effectively infer active biological networks in diverse cell types response these external stimuli. Here we present DeepMAPS for network inference from scMulti-omics. It models scMulti-omics a heterogeneous graph learns relations among cells genes within both local global contexts...
Abstract Flickering light stimulation has emerged as a promising non-invasive neuromodulation strategy to alleviate neuropsychiatric disorders. However, the lack of neurochemical underpinning hampered its therapeutic development. Here, we demonstrate that flickering triggered an immediate and sustained increase (up 3 h after flickering) in extracellular adenosine levels primary visual cortex (V1) other brain regions, function frequency intensity, with maximal effects observed at 40 Hz 4000...
Hemorrhagic transformation (HT) is a severe complication occurring in acute ischemic stroke (AIS) patients. Stress hyperglycemia frequent patients with illness such as stroke. We aimed to explore the association between stress and HT AIS patients.A total of 287 consecutive participants 285 age- sex-matched without were enrolled this study. Baseline glucose glycated hemoglobin (HbA1c) levels collected measure hyperglycemia. The ratio (SHR) was calculated by dividing fasting plasma at...
Post-stroke cognitive impairment (PSCI) is an increasingly prevalent sequel after stroke that may associate with poor functional outcome and increased risk of recurrent stroke. We aimed to explore the relationship between oxidative stress biomarkers presence PSCI. 193 first-ever acute ischaemic patients were consecutively enrolled in current study. The malondialdehyde (MDA) 8-hydroxydeoxyquanosine (8-OHdG) measured within 24 h admission. Cognition function was evaluated by Mini-Mental State...
Abstract Introduction Low serum vitamin D levels are associated with the development of poststroke depression (PSD). Inflammatory markers play an important role in pathophysiology PSD. The relationship between and inflammatory has been discussed nonstroke individuals. purposes this study were to explore acute stroke patients examine effect on Methods A total 152 recruited. Serum 25‐hydroxyvitamin measured by standardized laboratory methods. Depression symptoms assessed 17‐item Hamilton Scale...
Serum albumin to globulin ratio (AGR) is a marker of inflammatory disease, but its role in bowel disease (IBD) remains unknown. The primary purpose the present research was explore relationship between serum AGR and (IBD).A total 179 patients with ulcerative colitis (UC), 210 Crohn's (CD), non-IBD controls (age- gender-matched who have gastrointestinal (GI) symptoms) were enrolled research. Demographic data, endoscopic score, biomarkers such as C-reactive protein (CRP), erythrocyte...
Abstract Introduction Hemorrhagic transformation (HT) is a complex and multifactorial complication among patients with acute ischemic stroke (AIS), the inflammatory response has been considered as risk factor for HT. We aimed to evaluate stratification of FAR (fibrinogen‐to‐albumin ratio), an biomarker, in HT patients. Methods A total 256 consecutive age‐ gender‐matched without were included this study. during hospitalization was diagnosed by follow‐up imaging assessment classified into...
Abstract The excessive buildup of neurotoxic α-synuclein plays a pivotal role in the pathogenesis Parkinson's disease, highlighting urgent need for innovative therapeutic strategies to promote clearance, particularly given current lack disease-modifying treatments. glymphatic system, recently identified perivascular fluid transport network, is crucial clearing proteins. This review aims synthesize knowledge on system clearance and its implications pathology disease while emphasizing...
Osteoporotic vertebral fractures and their complications pose increasing risks to the elderly. The purpose of this study was evaluate clinical efficacy unilateral percutaneous vertebroplasty in patients with osteoporotic compression (OVCF) by assessing postoperative cement distribution. This aimed investigate impact distribution on fracture repair provide effective preventive therapeutic measures, prevent re-fracture, improve surgical outcomes. A total 170 who underwent at our hospital from...
Objective This study aims to identify early warning indicators of COVID-19 severity by integrating modern medical biomarkers with traditional Chinese medicine (TCM) tongue features. Methods A retrospective observational was conducted on 409 hospitalized patients from two centers in China. Patients were stratified into severe ( n = 50) and non-severe 359) groups based the 10th edition China’s diagnostic guidelines. Data included demographics, clinical symptoms, characteristics, laboratory...
Previous studies found that low vitamin D levels were modestly associated with risk of stroke and poor functional outcome after stroke. In addition, deficiency has been linked cognitive decline. Our study aimed to explore the potential relationship between in short-term acute phase ischemic impairment at 1 month.In total, 354 patients consecutively enrolled received 1-month follow-up. The serum measured within 24 hours admission. Cognitive function was evaluated by Mini-Mental State...
Abstract Introduction Studies have shown that high levels of the fibrinogen (FIB) are related to cognitive deficits. However, relationship between and deficit after stroke remains unclear. Therefore, we explored plasma post‐stroke impairment (PSCI). Methods This study is carried out in First Affiliated Hospital Wenzhou Medical University, Wenzhou, Zhejiang Province, China. A total 210 patients with acute ischemic were enrolled this study. Ultimately, 134 completed 3‐month follow‐up. Blood...
Objective This study aims to examine the association between Weight-adjusted Waist Circumference Index (WWI) and prevalence of periodontitis, providing novel evidence on link central obesity periodontal health. Methods A cross-sectional was conducted with 10,289 participants enrolled from NHANES 2009 2014. WWI calculated by dividing waist circumference square root weight. We employed a multivariate logistic regression model smoothed curve fitting method evaluate relationship periodontitis....
Background The neutrophil-to-lymphocyte ratio (NLR) is a biomarker reflecting the balance between inflammation (as indicated by neutrophil count) and adaptive immunity lymphocyte count). We aimed to estimate ability of NLR at admission day 1 for predicting stroke outcome after two reperfusion therapies: intravenous thrombolysis (IVT) mechanical thrombectomy (MT). Methods A retrospective analysis was performed on patients who received recombinant human tissue plasminogen activator and/or...
The structures and thermal expansion properties of Lu2−xFexMo3O12 have been investigated by X-ray diffraction (XRD). XRD patterns at room temperature indicate that compounds with x ≤ 1.3 exhibit an orthorhombic structure space group Pnca; = 1.5 1.7 a monoclinic P21/a. Studies on show the linear coefficients phase vary from negative to positive increasing Fe content. Attempts make zero materials can be observed in Lu1.3Fe0.7Mo3O12 range 200–400 °C.
The crystal structures, phase transition, and thermal expansion behaviors of solid solutions Sc2–xFexMo3O12 (0 ≤ x 2) have been examined using X-ray diffraction (XRD), neutron powder (NPD), differential scanning calorimetry (DSC). At room temperature, samples crystallize in a single orthorhombic structure for the compositions < 0.6 monoclinic ≥ 0.6, respectively. DSC results indicate that transition temperature from to is enhanced by increasing Fe3+ content. High-temperature XRD NPD show...
Abstract Background Although isolated distal deep vein thrombosis (IDDVT) is a clinical complication for acute ischemic stroke (AIS) patients, very few clinicians value it and methods can predict early IDDVT. This study aimed to establish validate an individualized predictive nomogram the risk of IDDVT in AIS patients. Methods enrolled 647 consecutive patients who were randomly divided into training cohort ( n = 431) validation 216). Based on logistic analyses cohort, was constructed The...