A5077527648- Health, Medicine and Society
- Transcranial Magnetic Stimulation Studies
- Muscle activation and electromyography studies
- Spaceflight effects on biology
- Cerebral Palsy and Movement Disorders
- Children's Physical and Motor Development
- Neuroscience and Neuropharmacology Research
- Muscle Physiology and Disorders
- Adipose Tissue and Metabolism
- Neural dynamics and brain function
- Pain Mechanisms and Treatments
- Sleep and Wakefulness Research
- Infant Development and Preterm Care
- Motor Control and Adaptation
- Genetic Neurodegenerative Diseases
- Spinal Cord Injury Research
- Mitochondrial Function and Pathology
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Anesthesia and Neurotoxicity Research
- Hemispheric Asymmetry in Neuroscience
- Neurological disorders and treatments
- Nerve injury and regeneration
- Cardiovascular and exercise physiology
- Neonatal and fetal brain pathology
Université d'Artois
2022-2025
Université de Lille
2015-2025
Unité de Recherche Pluridisciplinaire Sport, Santé, Société
2015-2025
ATS Sardegna (Italy)
2025
Laboratoire Plasticité du Cerveau
2001-2016
Université Lille Nord de France
2010-2015
Laboratoire Paul Painlevé
1995-2012
University of the Sciences
2000
Sorbonne Université
1992-1994
Centre National de la Recherche Scientifique
1993-1994
A sedentary lifestyle can lead to motor and cognitive deficits, increasing the risk of neurodegenerative diseases in ageing. Emerging hypotheses suggest that these functional alterations may be related energy metabolism. Indeed, ATP produced by mitochondria is essential for muscle contraction, neurotransmission brain plasticity processes. Although a has been associated with mitochondrial skeletal muscle, potential effects on structures have yet investigated. The present study aimed determine...
Abstract Motor control and body representations in the central nervous system are built, i.e., patterned, during development by sensorimotor experience somatosensory feedback/reafference. Yet, early emergence of locomotor disorders remains a matter debate, especially absence brain damage. For instance, children with developmental coordination (DCD) display deficits planning, executing controlling movements, concomitant executive functions. Thus, atypicalities at origin long-lasting abnormal...
Childhood is a period of construction the organism, during which interactions with environment and regular physical activity are necessary for maturation neuronal networks. An atypical sensorimotor childhood (due to bed-rest or neurodevelopmental disorders) impacts development neuromuscular system. A model restriction (SMR) developed in rats has shown that casting pups' hind limbs from postnatal day 1 (P1) P28 induced severe perturbation motor behavior, due muscle weakness as well...
The effects of clenbuterol beta(2)-agonist administration were investigated in normal and atrophied [15-day hindlimb-unloaded (HU)] rat soleus muscles. We showed that had a specific effect on muscle tissue, since it reduces atrophy induced by HU. study Ca(2+) activation properties single skinned fibers revealed partly prevented the decrease maximal tension after HU, with preferential fast-twitch fibers. Clenbuterol improved sensitivity slow- shifting tension-pCa relationship toward lower...
Motor control and body representation in the central nervous system (CNS) as well musculoskeletal architecture physiology are shaped during development by sensorimotor experience feedback, but emergence of locomotor disorders maturation their persistence over time remain a matter debate absence brain damage. By using transient immobilization hind limbs, we investigated enduring impact postnatal restriction (SMR) on gait posture treadmill, age-related changes locomotion, histopathology...
Abstract Children with neurodevelopmental disorders, such as developmental coordination disorder (DCD), exhibit gross to fine sensorimotor impairments, reduced physical activity and interactions the environment people. This co‐exists cognitive deficits, executive dysfunctions learning impairments. Previously, we demonstrated in rats that limited amounts atypical patterns of movements somatosensory feedback during early movement restriction manifested adulthood degraded postural locomotor...
Intrauterine ischemia-hypoxia is detrimental to the developing brain and leads white matter injury (WMI), encephalopathy of prematurity (EP), often cerebral palsy (CP), but related pathophysiological mechanisms remain unclear. In prior studies, we used mild intrauterine hypoperfusion (MIUH) in rats successfully reproduce diversity clinical signs EP, some CP symptoms. Briefly, MIUH led inflammatory processes, diffuse gray WMI, minor locomotor deficits, musculoskeletal pathologies,...
A chronic reduction in neuromuscular activity through prolonged body immobilization human alters motor task performance a combination of peripheral and central factors. Studies performed rat model sensorimotor restriction have shown functional biochemical changes cortex. However, the underlying mechanisms are still unclear. Interest was turned towards possible implication Insulin-like Growth Factor 1 (IGF-1), growth factor known to mediate neuronal excitability synaptic plasticity by...
Environmental changes that occur in daily life or, particular, situations like actual or simulated microgravity require neuronal adaptation of sensory and motor functions. Such conditions can exert long-lasting disturbances on an individual's adaptive ability. Additionally, prenatal stress also leads to behavioral physiological abnormalities adulthood. Therefore, the aims present study were (a) evaluate adult rats follows 14 days exposure (hindlimb unloading) (b) determine whether restraint...