A5114334475- Telomeres, Telomerase, and Senescence
- RNA modifications and cancer
- Tissue Engineering and Regenerative Medicine
- Genetics, Aging, and Longevity in Model Organisms
- Cancer Cells and Metastasis
- Bacterial Genetics and Biotechnology
- Erythrocyte Function and Pathophysiology
- Neonatal Respiratory Health Research
- Mesenchymal stem cell research
- RNA Interference and Gene Delivery
- Chronic Lymphocytic Leukemia Research
- SARS-CoV-2 and COVID-19 Research
- Ion channel regulation and function
- Health, Environment, Cognitive Aging
- Immune responses and vaccinations
- Quinazolinone synthesis and applications
- Muscle Physiology and Disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Mechanisms and Therapy
- Molecular Biology Techniques and Applications
- COVID-19 Clinical Research Studies
- Cancer-related gene regulation
- Diet and metabolism studies
- Pancreatic and Hepatic Oncology Research
- Microplastics and Plastic Pollution
Hospital of Hebei Province
2024
Hangzhou Normal University
2012-2023
Northern Jiangsu People's Hospital
2021
National Institute of Diabetes and Digestive and Kidney Diseases
2020
National Institutes of Health
2020
Jinan Central Hospital
2020
Shandong First Medical University
2020
Nanjing University
2014
Nanjing Medical University
2014
Abstract The cell entry of SARS-CoV-2 has emerged as an attractive drug repurposing target for COVID-19. Here we combine genetics and chemical perturbation to demonstrate that ACE2-mediated SARS-Cov CoV-2 requires the surface heparan sulfate (HS) assisting cofactor: ablation genes involved in HS biosynthesis or incubating cells with a mimetic both inhibit Spike-mediated viral entry. We show heparin/HS binds Spike directly, facilitates attachment Spike-bearing particles promote screened...
Abstract Controversies and risks continue to be reported about exogenous mesenchymal stem cell‐based therapies. In contrast with employing cells, making use of lung resident cells (LR‐MSCs) could advantageous. Our study sought isolate the LR‐MSCs explore their potential differentiate into alveolar epithelial type II (ATII cells). Total were first precultured, from which Sca‐1 + CD45 − CD31 population was purified using fluorescence activated cell sorting (FACS). By these methods, it would...
Oxidative stress regulates telomere homeostasis and cellular aging by unclear mechanisms. Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is a key mediator of many oxidative responses, involving GAPDH nuclear translocation induction cell death. We report here that interacts with the telomerase RNA component (TERC), inhibits activity, induces shortening breast cancer senescence. The Rossmann fold containing NAD + binding region on responsible for interaction TERC, whereas lysine residue in...
Mechanical ventilation can induce or aggravate lung injury, which is termed ventilator-induced injury (VILI). Piezo1 a key element of the mechanotransduction process and transduce mechanical signals into biological by mediating Ca2+ influx, in turn regulates cytoskeletal remodeling stress alterations. We hypothesized that it plays an important role occurrence VILI, investigated underlying mechanisms.High tidal volume high magnitude cyclic stretch were performed on Sprague-Dawley rats, A549...
Abstract Human telomerase reverse transcriptase (hTERT) plays a central role in telomere lengthening for continuous cell proliferation, but it remains unclear how extracellular cues regulate of telomeres. Here we report that the cytokine bone morphogenetic protein-7 (BMP7) induces hTERT gene repression BMPRII receptor- and Smad3-dependent manner human breast cancer cells. Chonic exposure cells to BMP7 results short telomeres, senescence apoptosis. Mutation receptor, not TGFbRII, ACTRIIA or...
Pulmonary premature ageing and fibrogenesis as in idiopathic pulmonary fibrosis (IPF) occur with the DNA damage response lungs deficient of telomerase. The molecular mechanism mediating alveolar cell fates remains to be investigated. present study shows that naturally occurring is associated (DDR) activation p53 signalling pathway. Telomerase deficiency induced by telomerase RNA component (TERC) knockout (KO) accelerates not only replicative senescence but also altered differentiation...
Telomere shortening results in cellular senescence and the regulatory mechanisms remain unclear. Here, we report that sub-telomere regions facilitate telomere lengthening by homologous recombination, thereby attenuating yeast Saccharomyces cerevisiae. The protein complex Sir3/4 represses, whereas Rif1 promotes, Y′ element recombination. Genetic disruption of SIR4 increases abundance rescues telomere-shortening-induced a Rad51-dependent manner, indicating switch regulating organismal DNA...
Abstract Pulmonary senescence and fibrosis occur with deoxyribonucleic acid (DNA) damage response in the lungs deficient of telomerase. The molecular mechanism mediating pulmonary alveolar cell fates remains to be investigated. present study shows that epithelial type 2 cells (AEC2) (alveolar stem cells) undergo not only replicative senescence, but also apoptosis differentiation association increased innate immune natural killer (NK) telomerase knockout (KO) mice. Telomerase ribonucleic...
<div>Abstract<p><b>Purpose:</b> Mothers against decapentaplegic homologue 4 (<i>SMAD4</i>) is a tumor suppressor gene associated with gastrointestinal carcinogenesis. The aim of the present study to more precisely characterize its role in development and progression human gastric carcinoma.</p><p><b>Experimental Design:</b> expression SMAD4 was investigated 283 adenocarcinomas related lesions, as well 9 carcinoma cell lines. We also...
Stabilization of a G-quadruplex (G4) in the promotor c-MYC proto-oncogene leads to inhibition gene expression, and it thus represents potentially attractive new strategy for cancer treatment. However, most G4 stabilizers show little selectivity among many G4s present cellular complement DNA RNA. Intriguingly, crescent-shaped cell-penetrating thiazole peptide, TH3, preferentially stabilizes over other G4s, but mechanisms leading this selective binding remain obscure. To investigate these at...
Abstract Background: Mechanical ventilation can induce or aggravate lung injury, which is termed ventilator‑induced injury. Piezo1 a key element of the mechanotransduction process and transduce mechanical signals into biological by mediating Ca2+ influx, in turn regulates cytoskeletal remodeling stress alterations. We hypothesized that it plays an important role occurrence we investigated underlying mechanisms. Methods: High tidal volume high magnitude cyclic stretch were performed on...