A5039393896- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Transcranial Magnetic Stimulation Studies
- Neurological disorders and treatments
- Plant and animal studies
- Neurobiology and Insect Physiology Research
- EEG and Brain-Computer Interfaces
- Neuroscience and Music Perception
- Circadian rhythm and melatonin
- Memory and Neural Mechanisms
- Neurotransmitter Receptor Influence on Behavior
UNSW Sydney
2020-2024
The University of Queensland
2017
Previous studies indicate that rewards and punishments in reinforcement learning are encoded a relative manner. Reference point-dependence, valuation bias shared by eminent adaptation level prospect theories, is often cited as the underlying computational mechanism. However, whether these behavioural mechanisms preserved across species unknown. To fill this gap, we designed task was adapted for both humans (homo sapiens sapiens) rats (rattus norvegicus). Behavioural analyses indicated robust...
The dopamine ontogeny hypothesis for schizophrenia proposes that transient dysregulation of the dopaminergic system during brain development increases likelihood this disorder in adulthood. To test a high throughput animal model, we have transiently manipulated signaling developing fruit fly Drosophila melanogaster and examined behavioral responsiveness adult flies. We found either increase neuron activity or decrease receptor expression permanently impairs adults. A screen impaired revealed...
Streamlined action sequences must remain flexible should stable contingencies in the environment change. By combining analyses of behavioral structure with a circuit-specific manipulation mice, we report on relationship between timing variability and successful adaptation that relates to post-synaptic targets primary motor cortical (M1) projections dorsolateral striatum (DLS). In two-lever instrumental task, mice formed by, first, establishing scaffolds and, second, smoothly extending...
Summary The acquisition of goal-directed action requires the encoding specific action-outcome associations involving plasticity in posterior dorsomedial striatum (pDMS). We first investigated relative involvement major inputs to pDMS argued be involved this learning-related plasticity, from prelimbic prefrontal cortex (PL) and basolateral amygdala (BLA). Using ex vivo optogenetic stimulation PL or BLA terminals pDMS, we found that learning potentiated input direct pathway spiny projection...
Abstract Performing several actions in swift succession is often necessary to exploit known contingencies the environment. However, order remain successful when contingency rules change, streamlined action sequences must be adaptable. Here, by combining analyses of behavioural microstructure with circuit-specific manipulation mice, we report on a relationship between timing variability and adaptation that relies post-synaptic targets primary motor cortical (M1) projections dorsolateral...