A. O. Lucas

ORCID: 0000-0003-4048-8656
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About
Contact & Profiles
Research Areas
  • Parasites and Host Interactions
  • Health Systems, Economic Evaluations, Quality of Life
  • HIV, Drug Use, Sexual Risk
  • Child and Adolescent Health
  • Fungal Infections and Studies
  • Diphtheria, Corynebacterium, and Tetanus
  • HIV/AIDS Research and Interventions
  • Helminth infection and control
  • Parasite Biology and Host Interactions
  • Pneumonia and Respiratory Infections
  • Respiratory viral infections research
  • HIV/AIDS Impact and Responses
  • Malaria Research and Control
  • Pharmaceutical studies and practices
  • Botulinum Toxin and Related Neurological Disorders
  • Tuberculosis Research and Epidemiology
  • Pharmacological Effects and Toxicity Studies
  • Amoebic Infections and Treatments
  • Trypanosoma species research and implications
  • Intramuscular injections and effects
  • Chronic Lymphocytic Leukemia Research
  • Parvovirus B19 Infection Studies
  • Multiple Sclerosis Research Studies
  • Phytoplasmas and Hemiptera pathogens
  • Global Health and Surgery

RTI Health Solutions
2018-2023

Harvard University
1998-2015

Northwestern University
2012

Maastricht University
2008

University College Hospital, Ibadan
1969-1986

Special Programme for Research and Training in Tropical Diseases
1985

World Health Organization
1985

University of Ibadan
1965-1978

Wellcome Trust
1969

University of the West Indies System
1965

Underdiagnosis and undertreatment of patients with asthma or chronic obstructive pulmonary disease are widely discussed in the literature. Not much is known about possible overdiagnosis consequently overtreatment inhaled corticosteroids (ICS). Aim. This study investigates how often ICS prescribed without a proper indication big diagnostic problem caused by inappropriate prescription use ICS.All referred to primary care centre during 6 months who used clear were included. Their GPs questioned...

10.1093/fampra/cmn006 article EN Family Practice 2008-02-27

Twenty-two of 24 cases Mycobacterium ulcerans infection in Ibadan are reviewed. The patients included Africans, Caucasians, and Indians. There were no differences between races the manifestations disease. average age was higher than that other reports literature. fact most originally wrongly diagnosed reemphasizes need to search for M. "tropical" ulcer fail respond adequate therapy. Early recognition surgery mainstay treatment. Comexazole seems more effective clofazimine treatment these ulcers.

10.4269/ajtmh.1976.25.122 article EN American Journal of Tropical Medicine and Hygiene 1976-01-01

The antimalarial activity of pyrimethamine in combination either with dapsone or sulphormethoxine, was compared that alone. In this double-blind controlled study, 280 children, living an area stable P. falciparum malaria, were observed during one year. With alone there incomplete suppression parasitaemia crude parasite rates ranging from 2 to 25%. first dose the drug combinations produced a rapid clearance parasitaemia, and weekly administration sustained virtually complete throughout drugs...

10.1016/0035-9203(69)90150-3 article EN Transactions of the Royal Society of Tropical Medicine and Hygiene 1969-01-01

Currently, the 13-valent pneumococcal conjugate vaccine (PCV13) is administered under a 1+1 (1 primary dose) pediatric schedule in United Kingdom (UK). Higher-valency PCVs, 15-valent PCV (PCV15), or 20-valent (PCV20) might be considered to expand serotype coverage. We evaluated cost-effectiveness of PCV20 PCV15 using either 2+1 (2 doses) for immunization UK. Using dynamic transmission model, we simulated future disease incidence and costs PCV13 1+1, 2+1, schedules from UK National Health...

10.3390/vaccines11071168 article EN cc-by Vaccines 2023-06-28

Objective: The current Centers of Disease Control and Prevention (CDC) guidelines from 2006 recommend a one-time test for low-risk individuals annual testing those at high risk. These may not be aggressive enough, even low risk infection, due to the earlier initiation HAART movement towards test-and-treat environment. We evaluated optimal frequencies various groups in comparison CDC recommendations. Methods: build deterministic mathematical model optimizing tradeoff between societal cost...

10.1097/qad.0b013e32835c54f9 article EN AIDS 2012-11-20

Abstract The 13-valent pneumococcal conjugate vaccine (PCV) has been part of routine immunisation in a 2 + 1 schedule (two primary infant doses and one booster during the second year life) UK since 2010. Recently, UK's Joint Committee on Vaccination Immunisation recommended changing to while conceding that this will increase disease burden; however, uncertainty remains how much burden – including invasive (IPD) non-invasive increase. We built dynamic transmission model investigate question....

10.1017/s095026881800198x article EN cc-by-nc-sa Epidemiology and Infection 2018-07-17

10.3171/jns.1968.29.4.0417 article EN Journal of neurosurgery 1968-10-01

10.1136/bmj.2.5474.1333 article EN BMJ 1965-12-04

A comparison was made of the immunity conferred by injected formalin-killed poliomyelitis vaccine and orally administered attenuated in Nigerian infants under tropical conditions where interfering enteroviruses have caused poor conversion rates with vaccine. Two hundred thirty completed immunization schedules. The levels antibodies to polioviruses were assessed before at periodic intervals during trial. Seventy-four per cent, 72% 85% children lacked poliovirus types 1, 2 3 respectively 6...

10.1080/00034983.1978.11719290 article EN Annals of Tropical Medicine and Parasitology 1978-04-01

10.1111/j.1749-6632.1969.tb15892.x article EN Annals of the New York Academy of Sciences 1969-10-01

Renal function in children infected with Schistosoma haematobium and uninfected controls has been studied the I131 hippuran renogram. The results suggest that renographic abnormalities which persist after a water-load are more common who have heavy egg-output their urine, abnormal pyelograms. Specific chemotherapy restored renogram to normal within 3 weeks several cases. It is suggested useful for assessment followup of patients vesical schistosomiasis, further work should be done clearly...

10.4269/ajtmh.1975.24.274 article EN American Journal of Tropical Medicine and Hygiene 1975-03-01

This study is one of a series designed to determine the optimum dose antitoxin in tetanus. Each was allotted at random patients after diagnosis. With sequential analysis, trial stopped 270 had been treated. It concluded that lower least as effective higher.

10.1002/cpt196565592 article EN Clinical Pharmacology & Therapeutics 1965-09-01

Empirical estimates of the female-to-male ratio infections in generalized HIV epidemics sub-Saharan Africa range from 1.31 Zambia to 2.21 Ivory Coast. Inequalities gender can arise because differences exposure (

10.4054/demres.2015.33.15 article EN cc-by-nc Demographic Research 2015-09-02

(1972). Treatment of hookworm infection and other intestinal parasites with 1–tetramisole (Ketrax) Annals Tropical Medicine & Parasitology: Vol. 66, No. 3, pp. 391-398.

10.1080/00034983.1972.11686840 article EN Annals of Tropical Medicine and Parasitology 1972-09-01

In the United States (US), congenital cytomegalovirus infection (cCMVi) is a major cause of permanent disabilities and most common etiology non-genetic sensorineural hearing loss. Evaluations prevention strategies will require estimates economic implications cCMVi. We aimed to develop conceptual framework characterize lifetime burden cCMVi in US use that identify data gaps.Direct health care, direct non-health indirect, intangible costs associated with were considered. An initial was...

10.1186/s12962-019-0189-0 article EN cc-by Cost Effectiveness and Resource Allocation 2019-10-03
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