A5015558475- Parasites and Host Interactions
- Trace Elements in Health
- Parasite Biology and Host Interactions
- Helminth infection and control
- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Drug Transport and Resistance Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Macrophage Migration Inhibitory Factor
- Protein Kinase Regulation and GTPase Signaling
- Amyloidosis: Diagnosis, Treatment, Outcomes
Universidade Federal de Minas Gerais
2011
Fundação Oswaldo Cruz
2006-2011
Grupo Santa Casa de Belo Horizonte
2007
Abstract Background Schistosomiasis remains an important parasitic disease and a major economic problem in many countries. The Schistosoma mansoni genome predicted proteome sequences were recently published providing the opportunity to identify new drug candidates. Eukaryotic protein kinases (ePKs) play central role mediating signal transduction through complex networks are considered druggable targets from medical chemical viewpoints. Our work aimed at analyzing S. order classify all ePKs...
The draft nuclear genome sequence of the snail-transmitted, dimorphic, parasitic, platyhelminth Schistosoma mansoni revealed eight genes encoding proteins that contain Universal Stress Protein (USP) domain. is a causative agent human schistosomiasis, severe and debilitating Neglected Tropical Disease (NTD) poverty, which endemic in at least 76 countries. availability sequences species presents opportunities for bioinformatics genomics analyses associated gene families could be targets...
Schistosoma mansoni eggs, miracidia and primary sporocysts were labelled with phalloidin-rhodamine to visualize filamentous actin structures. Analysis of these forms by confocal fluorescence microscopy revealed the presence previously well-defined circular longitudinal muscle layers. Besides muscular layers that sustain provide motility parasite forms, we found in 3 consecutive developmental stages unidentified actin-rich tubular In 4 tubules could be observed optical sectioning underneath...
Schistosoma mansoni , one of the causative agents schistosomiasis, has a complex life cycle infecting over 200 million people worldwide. Such successful and prolific parasite been shown to be dependent on adaptive interaction between hosts. Tyrosine kinases (TKs) play key role in signaling pathways as demonstrated by large body experimental work eukaryotes. Furthermore, comparative genomics have allowed identification TK homologs provided insights into functional TKs several biological...