A5091489220- Neural dynamics and brain function
- Advanced Memory and Neural Computing
- Hearing Loss and Rehabilitation
- Neuroscience and Neuropharmacology Research
- Neuroscience and Music Perception
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
University of Illinois Urbana-Champaign
2018
Behavioral Pharma (United States)
2018
University of Connecticut
2012-2016
Spike timing-dependent plasticity (STDP) and other conventional Hebbian-type rules are prone to produce runaway dynamics of synaptic weights. Once potentiated, a synapse would have higher probability lead spikes thus be further but once depressed, tend depressed. The can prevented by precisely balancing STDP for potentiation depression; however, experimental evidence shows great variety depression windows magnitudes. Here we show that modifications synapses layer 2/3 pyramidal neurons from...
Associative Hebbian-type synaptic plasticity underlies the mechanisms of learning and memory; however, Hebbian rules lead to runaway dynamics weights lack for competition.Heterosynaptic may solve these problems by complementing at synapses that were active during induction, with opposite-sign changes non-activated synapses. In visual cortex, a potential candidate mechanism normalization is induced purely postsynaptic protocol, intracellular tetanization. Here we asked if tetanization can...
Mammals perceive a wide range of temporal cues in natural sounds, and the auditory cortex is essential for their detection discrimination. The rat primary (A1), ventral (VAF), caudal suprarhinal (cSRAF) cortical fields have separate thalamocortical pathways that may support unique cue sensitivities. To explore this, we record responses single neurons three to variations envelope shape modulation frequency periodic noise sequences. Spike rate, relative synchrony, first-spike latency metrics...
Long-range descending projections from the auditory cortex play key roles in shaping response properties inferior colliculus. The corticocollicular projection is massive and heterogeneous, with axons emanating cortical layers 5 6, plays a role directing plastic changes However, little known about thalamic networks within which neurons are embedded. Here, laser scanning photostimulation glutamate uncaging photoactivation of channelrhodopsin-2 were used to probe local long-range network...
Auditory cortex is essential for mammals, including rodents, to detect temporal "shape" cues in the sound envelope but it remains unclear how different cortical fields may contribute this ability (Lomber and Malhotra, 2008; Threlkeld et al., 2008). Previously, we found that precise spiking patterns provide a potential neural code shape primary auditory (A1), ventral field (VAF) caudal suprarhinal (cSRAF) of rat (Lee 2016). Here, extend these findings characterize time course temporally...