A5102810647- Nanoplatforms for cancer theranostics
- Ultrasound and Hyperthermia Applications
- Cancer, Stress, Anesthesia, and Immune Response
- Extracellular vesicles in disease
- Cancer, Hypoxia, and Metabolism
- Memory and Neural Mechanisms
- Immunotherapy and Immune Responses
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Photoacoustic and Ultrasonic Imaging
- Effects of Radiation Exposure
- Radiomics and Machine Learning in Medical Imaging
- Breast Cancer Treatment Studies
- Silk-based biomaterials and applications
- Genetic and Kidney Cyst Diseases
- Coronary Interventions and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Ultrasound and Cavitation Phenomena
- Photodynamic Therapy Research Studies
- Cancer Cells and Metastasis
- Education and Work Dynamics
- Enhanced Recovery After Surgery
- Hepatocellular Carcinoma Treatment and Prognosis
- Engineering Education and Curriculum Development
- Reproductive System and Pregnancy
China Three Gorges University
2013-2025
Children's Hospital of Zhejiang University
2022
Wuhan University
2020-2021
Second Hospital of Yichang
2021
Second Affiliated Hospital of Zhejiang University
2019
National Clinical Research Center for Digestive Diseases
2019
Rosalind Franklin University of Medicine and Science
2005-2008
Franklin University
2005
Addiction is believed to involve glutamate-dependent forms of synaptic plasticity that promote the formation new habits focused on drug seeking. We used primary cultures rat prefrontal cortex (PFC) neurons explore mechanisms by which dopamine-releasing psychomotor stimulants such as cocaine and amphetamine influence plasticity, focusing AMPA receptor trafficking because its key role in long-term potentiation (LTP). Brief stimulation D 1 dopamine receptors increased surface expression...
Postsynaptic interactions between dopamine (DA) and glutamate receptors in the nucleus accumbens (NAc) are critical for addiction. To determine effect of acute repeated DA receptor stimulation on AMPA (AMPAR) synaptic targeting medium spiny NAc neurons, we developed a model system consisting rat neurons cocultured with prefrontal cortex from enhanced green fluorescent protein-expressing mice. Cortical restore excitatory input onto but distinguishable based fluorescence. First, showed that...
Abstract Hypoxia‐induced resistance to tumor treatment restricts further development of photodynamic therapy. Instead simple reoxygenation relieve hypoxia in traditional therapeutic approaches, a mitochondria‐targeted reactive oxygen species (ROS) amplifier is constructed reverse and enhance sensitivity hypoxia‐resistant Mesoporous silica nanoparticles are modified with triphenylphosphine its blood circulation endow it specificity. α‐Tocopherol succinate indocyanine green loaded mesoporous...
Purpose: Immune checkpoint inhibitors (ICIs) and sonodynamic therapy (SDT) are types of immunotherapy. In order to combine soluble programmed cell death protein 1 (sPD-1)-mediated immune chlorin e6 (Ce6)-assisted SDT, nanobubbles (NBs) were generated simultaneously load sPD-1 Ce6. Materials Methods: The sPD-1/Ce6-NBs, which prepared by thin-film hydration mechanical oscillation, had a stable physical condition, delivered Ce6 in targeted manner. NBs could strengthen tumor suppression...
Ultrasound nanobubbles (NBs) can kill tumor cells, mediated by their effects of cavitation and acoustic perforation through ultrasound, while as novel drug carriers, biomaterial-modified NBs release drugs at a target region. In this work, the ultrasound bridged biotin-streptavidin were prepared simultaneously to be loaded with both programmed death ligand 1 monoclonal antibody (PD-L1 mAb) doxorubicin (DOX), which are immune checkpoint inhibitors (ICIs) chemotherapeutic agents, synergize...
Although immunotherapy has merged as an ideal cancer therapeutic strategy for preventing tumor growth and recurrence, effective approaches to treat immunologically cold tumors are still lacking. Herein, we reported a practical extendable nanoplatform (HA/ZIF-8@ICG@IMQ) that facilely integrated various therapeutics functions boosting host antitumor immunity tumors. The tumor-targeted microenvironment-responsive HA/ZIF-8@ICG@IMQ facilitated the tumor-specific accumulation release of...
The strategy of nanobubble-based anti-hepatocellular carcinoma therapy combining immune check inhibitors and sonodynamic therapy.
The incidence of malignant tumors is rising rapidly and tends to be in the younger, which has been one most important factors endangering safety human life. Ultrasound micro/nanobubbles, as a noninvasive highly specific antitumor strategy, can reach destroy tumor tissue through their effects cavitation acoustic perforation under guidance ultrasound. Meanwhile, micro/nanobubbles are now used novel drug carrier, releasing drugs at target region, especially on prospects biomaterial-modified...
Abstract Combination of anti‐metastasis antagonists with cytotoxic agents has shown clinical activity, yet is constrained unconditional activation and low tumor selectivity. Here, a chemokine receptor‐targeted metallo‐nanodrug reported for in situ generated hyperthermia‐enhanced oxidative stress metastatic pathway blockade specificity to treat breast cancer metastasis. The self‐assembled metallo‐nanodrugs trigger reactive oxygen species (ROS) generation stimuli, self‐amplify ROS level upon...
Objective To investigate the expression of Smad3 (mothers against decapentaplegic homolog 3) protein in postnecrotizing enterocolitis stricture and its possible mechanism action. Methods We used immunohistochemistry to detect characteristics nuclear factor kappa B (NF-κB) proteins human stricture. cultured IEC-6 (crypt epithelial cells rat small intestine) vitro inhibited using siRNA technique. Quantitative PCR, western blotting, ELISA were changes transforming growth factor-β1 (TGF-β1),...
The incidence of pancreatic benign tumors is lower than that malignant in previous clinical record. However, with the wide accessible and application sophisticated equipments techniques recent decades, more have been detected. Accu-rate imaging diagnosis differential one important approaches to differentiate tumor benignancy or malignancy, it essential for clinicians select proper treatment management. purpose this article review current medical be-nign highlight progress field. Key...
This article elaborated on the necessity and importance of reform medical education administration system in comprehensive university promoting development education,from point merging universities.It also emphasized long-term nature complexity process.In meantime,it introduced measures effects author's university. Key words: Medical education; Administration system; Reform practice