A5050983161- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Noise Effects and Management
- Vestibular and auditory disorders
- Ear Surgery and Otitis Media
- Neural dynamics and brain function
- Biochemical Analysis and Sensing Techniques
- Meningioma and schwannoma management
- Olfactory and Sensory Function Studies
- Effects of Vibration on Health
- Bat Biology and Ecology Studies
- Nasal Surgery and Airway Studies
- Color Science and Applications
- Musicians’ Health and Performance
- Molecular spectroscopy and chirality
- Biochemical effects in animals
- Marine animal studies overview
- Airway Management and Intubation Techniques
- Mechanical stress and fatigue analysis
- Trigeminal Neuralgia and Treatments
- Axon Guidance and Neuronal Signaling
- Nicotinic Acetylcholine Receptors Study
- Animal Vocal Communication and Behavior
- Connexins and lens biology
- Chronic Obstructive Pulmonary Disease (COPD) Research
Loma Linda University
2006-2020
VA Loma Linda Healthcare System
2008-2020
Loma Linda University Medical Center
2008-2015
University of Colorado Anschutz Medical Campus
2004-2015
Jerry L. Pettis Memorial VA Medical Center
2007
University of Colorado Health
2003-2005
American Speech Language Hearing Association
2004
United States Public Health Service
2003
University of Colorado Denver
2003
University of Miami
1993-2002
The effects of primary-tone separation on the amplitude distortion-product emissions (DPEs) at 2f1−f2 frequency were systematically examined in ten ears five subjects. All individuals had normal hearing and middle-ear function based upon standard clinical measures. Acoustic-distortion products elicited 1, 2.5, 4 kHz by equilevel primaries 65, 75, 85 dB SPL, while f2/f1 ratios varied 0.02 increments from 1.01–1.41 (4 kHz), 1.01–1.59 (2.5 or 1.01–1.79 (1 kHz). A principal outcome reflected...
Distortion product otoacoustic emissions (DPEs) at the 2f1-f2 frequency were recorded from 44 normal ears in response to equilevel primary tones. Detailed testing included recording of DPE "audiograms" 100-Hz steps 1 8 kHz three primary-tone levels (65, 75, and 85 dB sound pressure level [SPL]). In addition, response-growth or input-output (I/O) functions depicting relationship amplitudes DPEs levels, ranging 25 SPL 5-dB steps, also tested for 11 frequencies distributed quarter-octave...
The results of studies the physiological vulnerability distortion-product otoacoustic emissions (DPOAEs) suggest that DPOAE at 2f1−f2 in vertebrate ears is generated by more than one source. principal aims present study were to provide independent evidence for existence source, and determine contributions each ear-canal signal. To accomplish these aims, specific stimulus parameters separately systematically varied detailed parametric information regarding amplitude phase normal awake...
The 2f1−f2 distortion-product otoacoustic emission (DPOAE) is evoked by two primary tones of frequencies f1<f2, and levels L1 L2. Previous reports indicate that decreasing L2 below L1=L2 can; (1) increase DPOAE amplitude in normal ears, (2) the degree to which amplitudes are reduced cochlear trauma. Although both these factors could be advantageous for clinical applications DPOAEs, neither has been explored detail. In present study, DPOAE-amplitude frequency functions were collected...
In a previous report, it was shown that, in normal rabbit ears, the amplitude and phase of 2f1-f2 distortion-product otoacoustic emissions (DPOAEs) elicited by low-level (< 60-70 dB SPL) stimuli display differential dependence on stimulus parameters to those evoked high-level (> stimuli, indicating differences underlying generation mechanisms. present study, physiological vulnerability DPOAEs each two DPOAE-response regions identified basis parametric properties, characterized. Thus using...
Previous measures of distortion-product otoacoustic emissions (DPOAEs) in young adults suggested that these responses were capable detecting the functional effects auditory aging. The primary goal present study was to provide more detailed evidence for influence aging processes on ability healthy, older ears generate DPOAEs. Toward this end, DPOAEs examined a series human subjects, with clinically normal hearing, ranging age from 31 60 years. Acoustic-distortion products measured two basic...
Otoacoustic emissions can be used to study cochlear function in an objective and noninvasive manner. These features of emitted responses have stimulated a great deal investigation into the utility evoked as clinical tests hearing. One practical essential aspect any measure is consistency its result upon repeated testing same individual (i.e., test/retest reliability). The goal present work was conduct systematic reliability two emission types, transiently distortion-product otoacoustic...
Otoacoustic emissions have great promise for use in clinical tests of the functional status outer hair cells, which represent cochlear structures that make a major contribution to hearing process. A substantial literature is available concerning evaluation cell function by transiently evoked otoacoustic emissions. However, relatively little attention has been focused on benefits testing with distortion-product The purpose this presentation provide knowledge principal advantages offered testing.
Previous studies indicate that the amplitude of 2f1−f2 distortion-product otoacoustic emissions (DPOAEs), evoked by two tones frequencies f1&lt;f2, demonstrates a complex dependence on levels (L1 and L2) primary tones. In present study, DPOAE amplitudes were measured over wide range L1 L2 in normal human ears, allowing systematic, level-dependent asymmetry L1,L2 space to be characterized. The at which DPOAEs largest was close L1=L2 high stimulus levels, but moved monotonically toward...
This paper describes a method for visualization of the onset distortion-product otoacoustic emission (DPOAE) waveforms in time domain. The DPOAE are obtained using ensemble averaging samples microphone output. A rectangular sample window is used, and primary tones turned on within window. phases (f1 f2) varied systematically between such way that tones, all DPOAEs (e.g., 2 f2−f1, 3f1−2 f2, f1), except interest f1−f2), cancelled average. Visualization allows measurement latency (OSL) DPOAE....
The realization that otoacoustic emissions are sensitive to cochlear disorders has resulted in the speculation they may have considerable clinical potential as objective measures of hearing. To assess utility one type emission, distortion product emission (DPE), a study was undertaken individuals with hearing impairments representing number common otologic disorders. results this investigation provided evidence tests DPEs promise satisfy requirements important testing, including objectivity...
To develop an objective, fast, and simply performed screening protocol for cis ‐platinum (CP) ototoxicity, we compared the efficacy of with distortion‐product otoacoustic emissions (DPOAEs) outcome both conventional ultra‐high‐frequency (UHF) audiometry. Baseline audiometric DPOAE testing was in 66 patients, 33 whom met criteria inclusion final database. Comparisons were made between baseline measurements those recorded before subsequent CP infusions. Outcomes analyzed clinically paired...