A5102908887- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Glioma Diagnosis and Treatment
- Workplace Spirituality and Leadership
- Mindfulness and Compassion Interventions
- Immune Cell Function and Interaction
- Food Allergy and Anaphylaxis Research
- Job Satisfaction and Organizational Behavior
- Business and Economic Development
- Allergic Rhinitis and Sensitization
- Management and Organizational Practices
- Breast Implant and Reconstruction
- Collaboration in agile enterprises
- Economic Issues in Ukraine
- RNA Interference and Gene Delivery
- University-Industry-Government Innovation Models
- Cancer Genomics and Diagnostics
- Occupational Health and Safety Research
- Supply Chain Resilience and Risk Management
- Body Image and Dysmorphia Studies
- Antimicrobial Peptides and Activities
- Plant Reproductive Biology
- Brain Metastases and Treatment
- Biomedical Ethics and Regulation
CureVac (Germany)
2023-2024
Masaryk University
2020-2021
University of Szeged
2020
Medical University of Vienna
2004
Institute of Immunology
2003
University of Vienna
2002
In late summer, pollen grains originating from Compositae weeds (e.g., mugwort, ragweed) are a major source of allergens worldwide. Here, we report the isolation cDNA clone coding for Art v 1, allergen mugwort pollen. Sequence analysis showed that 1 is secreted with an N-terminal cysteine-rich domain homologous to plant defensins and C-terminal proline-rich region containing several (Ser/Ala)(Pro)2-4 repeats. Structural some proline residues in posttranslationally modified by hydroxylation...
Abstract Mugwort (Artemisia vulgaris) pollen allergens represent the main cause of pollinosis in late summer Europe. At least 95% sera from mugwort pollen-allergic patients contain IgE against a highly glycosylated 24- to 28-kDa glycoprotein. Recently, this major allergen, termed Art v 1, was characterized, cloned Escherichia coli, and produced recombinant form. In present study we characterized compared T cell responses natural (nArt 1) 1 (rArt 1). vitro nArt rArt were studied PBMC, lines...
Abstract Dendritic cells (DC), the most potent APC, are central to antimicrobial immunity. Because of evolutionary pressure, it is reasonable that pathogens have evolved strategies also subvert this host-defense mechanism. In present study, we describe a novel way bacterial interference with DC maturation. The metaboliten-butyrate, which occurs physiologically in high concentrations gastrointestinal tract and has well-known anti-inflammatory effects, able prevent LPS-induced maturation...
Pharmacological targeting of Janus kinase 3 (JAK3) has been employed successfully to control allograft rejection and graft-vs.-host disease (GVHD). Recent evidence suggests that in addition its involvement common-gamma chain (cγ) signaling cytokine receptors, JAK3 is also engaged the CD40 pathway peripheral blood monocytes. In this study, we assessed consequences inhibition during CD40-induced maturation myeloid dendritic cells (DCs), tested impact thereof on induction T-cell alloreactivity....
Background. Therapeutic targeting of Janus kinase 3 (JAK3) has received particular attention, because it is associated with the common γ signaling cytokine receptors and thus vitally influences T-cell growth survival. Recent evidence, however, indicates a critical role for JAK3 in linked to antigen receptor. Methods. In this study we investigated whether rationally designed inhibitor affects early activation events. T cells were stimulated by CD3 CD28 cross-linking, interleukin (IL)-2...
TPS2095 Background: Glioblastoma (GBM) is characterized by a low mutational burden limiting the number of neoantigen targets for cancer vaccines. Vaccination against tumor-associated antigens over-presented via MHC class I and II in GBM an alternative that has shown promise previous trials. A vaccine containing peptides presented HLA-A*02:01 (class I) some DR alleles II), showed evidence peripheral intratumoral vaccine-induced immune response these patients with GBM. Our study will assess...
This paper explores the relationship between individual mindfulness and organizational mindfulness. Many authors consider these concepts to be related interlocked, however, exact nature of this connection is still unclear. Therefore, we investigate link two using both literature review approach theoretical reflection. The results are classified synthesized in a constructive way into framework that sheds light on main aspects collective Our research shows existence implies level. Individual...
<h3>Background</h3> The investigational therapeutic mRNA-based vaccine, CVGBM, encodes five class 1 and three 2 epitopes derived from tumor-associated antigens with potential relevance in glioblastoma (GBM). Here, we present results an ongoing, first-in-human study evaluating the safety immunogenicity of CVGBM patients newly-diagnosed surgically resected <i>MGMT</i>-unmethylated GBM. <h3>Methods</h3> Eligible were HLA-A*02:01-positive had GBM (CNS WHO Grade 4) a gross total or partial...
Abstract INTRODUCTION CVGBM is an investigational therapeutic mRNA-based vaccine encoding 8 epitopes derived from tumor associated antigens with potential relevance in GBM. This ongoing, first-in-human study evaluating the safety of pts newly-diagnosed MGMT-unmethylated METHODS HLA-A*02:01-positive GBM (CNS WHO Grade [Gr] 4) who had a gross total or partial resection and completed radiotherapy ± concomitant temozolomide received on Days 1, 8, 15, 29, 43, 57 71 + 6 optional doses at 6-week...
Abstract BACKGROUND Glioblastoma (GBM) is characterized by a low mutational burden limiting the number of neoantigen targets for cancer vaccines. Vaccination against tumor-associated antigens over-presented via MHC class I and II in GBM an alternative that has shown promise previous trials. One vaccine containing peptides presented HLA-A*02-01 (class I) some DR alleles II), showed evidence peripheral vaccine-induced immune response these patients with GBM. Our study will assess safety...