A5055278364- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Attention Deficit Hyperactivity Disorder
- Child Development and Digital Technology
- Family and Disability Support Research
- Face Recognition and Perception
- Obsessive-Compulsive Spectrum Disorders
- Virology and Viral Diseases
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Child Nutrition and Feeding Issues
- Behavioral and Psychological Studies
- Neural dynamics and brain function
- Child and Animal Learning Development
- Neuroscience and Neural Engineering
- Memory and Neural Mechanisms
- Neural and Behavioral Psychology Studies
- Language Development and Disorders
- Ophthalmology and Visual Impairment Studies
- Genomic variations and chromosomal abnormalities
- Visual perception and processing mechanisms
- Congenital heart defects research
- Educational and Psychological Assessments
- Blind Source Separation Techniques
- Intergenerational Family Dynamics and Caregiving
University of Washington
2016-2025
Seattle Children's Hospital
2016-2025
Behavioral Tech Research, Inc.
2006-2024
Seattle University
2006-2024
Washington Center
2010-2024
Birkbeck, University of London
2023
Children’s Health Research Institute
2023
Stanford University
2023
Johns Hopkins All Children's Hospital
2022
Johns Hopkins University
2022
This article reviews behavioral and electrophysiological studies of face processing discusses hypotheses for understanding the nature impairments in autism. Based on results studies, this study demonstrates that individuals with autism have impaired discrimination recognition use atypical strategies faces characterized by reduced attention to eyes piecemeal rather than configural strategies. concludes are present early autism, 3 years age. Such detected abnormalities both (N170 reflecting...
This study utilized electroencephalographic recordings to examine whether young children with autism spectrum disorder (ASD) have impaired face recognition ability. High‐density brain event‐related potentials (ERPs) were recorded photos of the child's mother's versus an unfamiliar female and a favorite toy from ASD, typical development, developmental delay, all 3 4 years age ( N = 118). Typically developing showed ERP amplitude differences in two components, P400 Nc, familiar face, object....
Individuals with autism exhibit impairments in face recognition, and neuroimaging studies have shown that individuals abnormal patterns of brain activity during processing. The current study examined the temporal characteristics processing their relation to behavior.High-density event-related potentials (ERPs) were recorded images faces, inverted objects from 9 spectrum disorder (15-42 years old) 14 typical (16-37 old).With respect a face-sensitive ERP component (N170), exhibited longer N170...
The increased male prevalence of autism spectrum disorder (ASD) may be mirrored by the early emergence sex differences in ASD symptoms and cognitive functioning. female protective effect hypothesis posits that recurrence will higher among relatives probands. This study examined proband outcome development functioning high-risk younger siblings probands low-risk children. Prior to 18 months age, 1824 infants (1241 siblings, 583 low-risk) from 15 sites were recruited. Hierarchical generalized...
Abstract Evidence suggests that autism is associated with impaired emotion perception, but it unknown how early such impairments are evident. Furthermore, most studies have assessed perception in children required verbal responses, making results difficult to interpret. This study utilized high‐density event‐related potentials (ERPs) investigate whether 3–4‐year‐old spectrum disorder (ASD) show differential brain activity fear versus neutral facial expressions. It has been shown normal...
Abstract This review focuses on the postnatal neuroanatomical changes that arise during first years of human life. Development is characterized by 2 major organizational periods. The period begins at conception and includes histogenetic events such as neurulation, proliferation, migration, differentiation. It has been proposed these may be controlled genetic epigenetic events, which give rise to neural structures are amenable external influence. second a time reorganization in cortex. These...
Neuroimaging and behavioral studies have shown that children adults with autism impaired face recognition. Individuals also exhibit atypical event-related brain potentials to faces, characterized by a failure show negative component (N170) latency advantage compared nonface stimuli bilateral, rather than right lateralized, pattern of N170 distribution. In this report, performance 143 parents on standardized verbal, visual–spatial, recognition tasks was examined. It found exhibited...
Context:The amygdala is associated with socioemotional function and has been implicated in the pathophysiology of autism.Objective: To examine relationship between amygdalar volume at ages 3 4 years severity clinical course outcome 6 age children autism spectrum disorder.Design: Magnetic resonance images acquired were used to measure total cerebral, amygdalar, hippocampal volumes.Acquisition social communication skills was assessed semiannually using Vineland Adaptive Behavior...
Prospective longitudinal studies of infants with older siblings autism spectrum disorder (ASD) have indicated that differences in the neurocognitive systems underlying social attention may emerge prior to child meeting ASD diagnostic criteria. Thus, targeting early intervention might potential alter developmental trajectories for at high risk ASD. Electrophysiological and habituation measures were collected 6, 12, 18 months a group high-risk infant children (N = 33). Between 9 11 age,...
Autism spectrum disorder (ASD) is a neurodevelopmental that affects more than 1 % of the population and close to 20 prospectively studied infants with an older sibling ASD. Although significant progress has been made in characterizing emergence behavioral symptoms ASD, far less known about underlying disruptions early learning. Recent models suggest core aspects causal path ASD may only be apparent infancy. Here, we investigated social attention 6- 12-month-old who did not meet criteria for...
We characterized developmental outcomes of a large sample siblings at familial high‐risk autism spectrum disorder (ASD), who themselves did not have ASD ( n = 859), and low‐risk controls with no family history 473). report age 3 years using the Mullen Scales Early Learning, Autism Diagnostic Observation Schedule (ADOS), Interview—Revised (ADI‐R) adaptive functioning on Vineland Adaptive Behavior Scales. Around 11% had mild‐to‐moderate levels delay, rate higher than controls. The groups...
Clinical research in neurodevelopmental disorders remains reliant upon clinician and caregiver measures. Limitations of these approaches indicate a need for objective, quantitative, reliable biomarkers to advance clinical research. Extant suggests the potential utility multiple candidate biomarkers; however, effective application markers trials requires additional understanding replicability, individual differences, intra-individual stability over time. The Autism Biomarkers Consortium...
ABSTRACT Between 6 and 12 months, typically developing infants undergo a socio‐cognitive “revolution.” The Interactive Specialization (IS) theory of brain development predicts that these behavioral changes will be underpinned by developmental increases in the power topographic extent socially selective cortical responses. To test this hypothesis, we used EEG to examine selectivity for ecologically valid dynamic social versus non‐social stimuli large cohort 6‐ 12‐month‐old infants. Consistent...