A5027778946- Pain Mechanisms and Treatments
- Cannabis and Cannabinoid Research
- Osteoarthritis Treatment and Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Biochemical effects in animals
- Stress Responses and Cortisol
- Healthcare and Venom Research
- Ion Channels and Receptors
- Mesenchymal stem cell research
- Extracellular vesicles in disease
- Forensic Toxicology and Drug Analysis
- Rheumatoid Arthritis Research and Therapies
- Bone health and treatments
- Human Pose and Action Recognition
- Psychedelics and Drug Studies
- Spine and Intervertebral Disc Pathology
- Inflammatory mediators and NSAID effects
- MicroRNA in disease regulation
- Mental Health Research Topics
- Adipose Tissue and Metabolism
- Pharmacological Effects of Natural Compounds
- Protease and Inhibitor Mechanisms
- Computational Drug Discovery Methods
- Botanical Research and Chemistry
- Polyamine Metabolism and Applications
Maj Institute of Pharmacology
2017-2024
Polish Academy of Sciences
2018-2024
Science for Life Laboratory
2023-2024
Stockholm University
2023-2024
Wrocław University of Science and Technology
2023
Osteoarthritis (OA) is a degenerative joint disease that primarily affects people over 65 years old. During OA progression irreversible cartilage, synovial membrane and subchondral bone degradation observed, which results in the development of difficult-to-treat chronic pain. One most important factors inflammation. Both proinflammatory anti-inflammatory factors, as well extracellular matrix enzymes (matrix metalloproteinases (MMPs), play an role development. widely used animal models...
The endocannabinoid system became a promising target for osteoarthritis (OA) treatment. Functional selectivity of cannabinoids may increase their beneficial properties while reducing side effects. aim the present study was to evaluate analgesic potential two functionally biased CB2 agonists in different treatment regimens propose best pharmacological approach OA management.
Chronic pain is a major health problem that affects significant number of patients, resulting in personal suffering and substantial care costs. One the most commonly reported causal conditions osteoarthritis (OA). In addition to sensory symptoms, chronic shares an inherent overlap with mood or anxiety disorders. The involvement frontal cortex, striatum nucleus accumbens, affective processing still poorly understood. Male Wistar rats were divided into two groups: MIA (monoiodoacetate injected...
Osteoarthritis (OA) is a joint disease in which cartilage degenerates as result of mechanical and biochemical changes. The main OA symptom chronic pain involving both peripheral central mechanisms nociceptive processing. Our previous studies have implicated the benefits dual- over single-acting compounds interacting with endocannabinoid system (ECS) treatment. In present study, we focused on specific molecular alterations associated pharmacological was induced Wistar rats by intra-articular...
Osteoarthritis (OA) is a degenerative joint disease manifested by movement limitations and chronic pain. Endocannabinoid system (ECS) may modulate nociception via cannabinoid TRPV1 receptors. The purpose of our study was to examine alterations in the spinal endocannabinoid during pain development an animal model OA. Wistar rats received intra-articular injection 3mg sodium monoiodoacetate (MIA) into knee joint. Animals were sacrificed on day 2, 7, 14, 21, 28 after lumbar cord, cartilage...
Systems pharmacology employs computational and mathematical methods to study the network of interactions a drug may have within complex biological pathways. These tools are well suited for research on multitarget drugs, such as natural compounds, in diseases with etiologies, osteoarthritis (OA). The present focuses cannabidiol (CBD), non-psychoactive constituent cannabis, targeting over 60 distinct molecular targets potential treatment OA, degenerative joint disease leading chronic pain...
Osteoarthritis (OA) is a chronic joint disease in which cartilage degeneration leads to pain. The endocannabinoid system has attracted attention as an emerging drug target for OA. However, the therapeutic potential of cannabinoids limited by psychoactive side-effects related CB1 activation and tolerance development analgesic effects. β-Caryophyllene (BCP) low-efficacy natural agonist CB2 common constituent human diet with well-established anti-inflammatory properties. results presented...
Chronic pain is a main symptom of osteoarthritis (OA). Moreover, high percentage OA patients suffer from mental health problems. The endocannabinoid (EC) system has attracted attention as an emerging drug target for treatment together with its activity on the mesolimbic reward system. Understanding circuits that govern relief crucial search effective analgesics. Therefore, we investigated role EC dopamine (DA) and noradrenaline (NA) in animal model OA-related chronic pain. rats exhibited...
Abstract Osteoarthritis (OA) is one of the most common joint disorder, with pain accompanied by functional impairment, as pronounced clinical symptom. Currently used pharmacotherapy involves symptomatic treatment, that do not always provide adequate relief. This may be due to concomitance central sensitization and development neuropathic features in OA patients. Here we performed studies animal model investigate component. Intraarticular injection monoiodoacetate (MIA, 1mg) was induce Wistar...
Abstract The serotonin system is the main therapeutic target for antidepressant drugs, most notably selective reuptake inhibitors (SSRIs). SSRIs such as fluoxetine are routinely prescribed a first-line treatment depression, well range of comorbid conditions, however drugs’ mechanism not understood. In order to study molecular and transcriptional effects SSRI administration on their primary neurons we performed spatial transcriptomics, spatially resolved RNA-sequencing method in intact brain...
Chronic pain is a major health problem that afflicts significant number of patients, resulting in personal suffering, reduced productivity, and substantial care costs. One the most commonly reported causal conditions osteoarthritis (OA). In addition to sensory symptoms, chronic shares an inherent overlap with mood or anxiety disorders because itself has cognitive-evaluative component. The mutual involvement brain structures (the frontal cortex, striatum nucleus accumbens) affective...
Abstract Osteoarthritis (OA) is one of the most common joint disorder, with pain accompanied by functional impairment, as pronounced clinical symptom. Currently used pharmacotherapy involves symptomatic treatment that do not always provide adequate relief. This may be due to concomitance central sensitization and development neuropathic features in OA patients. Here we performed studies animal model investigate component. Intraarticular injection monoiodoacetate (MIA, 1 mg) was induce Wistar...