A5101770187- Lymphoma Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Viral-associated cancers and disorders
- T-cell and Retrovirus Studies
- RNA Interference and Gene Delivery
- Elasticity and Material Modeling
- Autophagy in Disease and Therapy
- Bone Tissue Engineering Materials
- Advanced Battery Technologies Research
- Metal and Thin Film Mechanics
- HIV Research and Treatment
- Viral Infections and Immunology Research
- Hepatitis C virus research
- RNA and protein synthesis mechanisms
- Cancer-related gene regulation
- Conducting polymers and applications
- Fuel Cells and Related Materials
- Chronic Lymphocytic Leukemia Research
- Polymer Nanocomposite Synthesis and Irradiation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Hepatitis B Virus Studies
- PI3K/AKT/mTOR signaling in cancer
University of Alberta
2014-2022
Wuhan University
2008-2014
University of California, Davis
2010
City University of Hong Kong
2008
Dalian Institute of Chemical Physics
2006
Chinese Academy of Sciences
2006
There is overwhelming evidence that tyrosine kinases play an important role in cancer development. As a prototype of targeted therapy, kinase inhibitors are now successfully applied to treatment. However, as single agents, have not achieved satisfactory results the treatment prostate cancer, principally due their inability efficiently kill tumor cells. The authors' laboratory has been interested Src complex progression, including induction androgen independence and metastasis. Previously,...
The serine protease Granzyme B (GzB) is primarily expressed by cytotoxic T lymphocytes and natural killer cells, functions in allowing these cells to induce apoptosis virally-infected or transformed cells. Cancers of both lymphoid non-lymphoid origin also express GzB, some cases this expression has been linked pathogenesis sensitizing tumour cell death. For example, GzB urothelial carcinoma was implicated promoting invasion, whereas its nasal-type NK/T lymphomas found correlate with...
Classical Hodgkin Lymphoma (cHL) is primarily a B cell lymphoid neoplasm and member of the CD30-positive lymphomas. cHL other lymphomas are characterized by elevated expression and/or constitutive activation activator protein-1 (AP-1) family transcription factors, c-Jun JunB; however, specific roles they play in pathobiology unclear. In this report we show that reducing either or JunB with short-hairpin RNAs (shRNAs) reduced growth lines vitro vivo, through impairing cycle transition G1. We...
Chronic hepatitis B virus (HBV) infection could cause severe liver disease including cirrhosis, hepatocellular carcinoma, and end-stage failure in HIV-positive individuals. The available data from clinical studies suggest that HIV modulates the HBV-specific T cell response. However, virological molecular aspects of HIV–HBV coinfection are currently poorly understood due to lack appropriate model systems. In this study, effect on life cycle HBV was explored using an vitro system. present show...
Abstract Anaplastic lymphoma kinase-positive, anaplastic large cell (ALK+ ALCL) is a T which features translocations or inversion involving the ALK tyrosine kinase gene, and results in oncogenic fusion proteins (e.g. NPM-ALK). The elevated expression and/or activation of activator protein-1 (AP-1) transcription factors, c-Jun JunB, another molecular feature ALK+ ALCL. c-Jun/JunB transcriptional targets are important pathobiology this lymphoma, several also therapeutic targets. To better...