A5038573006- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
Third Xiangya Hospital
2022
Central South University
2022
Southern Medical University
2017
Nanfang Hospital
2017
MiR-646 has been reported to be aberrantly expressed in human cancers. However, the underlying molecular mechanisms of action miR-646 gastric cancer (GC) have not yet investigated.In vitro function GC was evaluated using EdU assay, plate colony formation and matrigel invasion assay. Real-time PCR or western blotting performed detect FOXK1 expressions. In vivo tumour growth metastasis were conducted nude mice.MiR-646 expression downregulated tissues compared with adjacent normal tissues. Low...
Excessive hepatic lipid accumulation is involved in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). A previous study showed that circular RNA (circRNA) PTK2 was significantly downregulated NAFLD mice. However, detailed function circ remains unclear. high-fat diet (HFD) used to establish a mouse model NAFLD, and free acid (FFA) treatment an vitro NAFLD. Oil red O staining evaluate accumulation. The pathological changes mice were observed by HE staining. Western blotting RT-qPCR...