A5088087230- Muscle metabolism and nutrition
- Muscle Physiology and Disorders
- Genetics and Physical Performance
- Advanced Chemical Sensor Technologies
- Metabolomics and Mass Spectrometry Studies
- Exercise and Physiological Responses
University of Toronto
2020-2022
Following anabolic stimuli (mechanical loading and/or amino acid provision), the mechanistic target of rapamycin complex 1 (mTORC1), a master regulator protein synthesis, translocates toward cell periphery. However, it is unknown if mTORC1-mediated phosphorylation events occur in these peripheral regions or before translocation (i.e., central regions). We therefore aimed to determine cellular location event, RPS6Ser240/244, human skeletal muscle following stimuli. Fourteen young, healthy...
Dietary amino acids that are not oxidized retained in the body to support net protein anabolism, which is important for individuals aiming maintain or enhance lean mass. There limited methodologies with measure anabolism noninvasively response physiological stimuli (e.g. single meal feeding and exercise), represents a challenge research vulnerable populations. PURPOSE: To determine efficacy of novel, noninvasive stable isotope ‘breath test’ differences anabolic stimulus. METHODS: Fifteen...