A5011541056- Animal Nutrition and Physiology
- Genetic and phenotypic traits in livestock
- Livestock and Poultry Management
- Genetic Mapping and Diversity in Plants and Animals
- Animal Genetics and Reproduction
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- RNA and protein synthesis mechanisms
- Peroxisome Proliferator-Activated Receptors
- Cancer-related molecular mechanisms research
- interferon and immune responses
- MicroRNA in disease regulation
- melanin and skin pigmentation
- Genetic diversity and population structure
- Rabbits: Nutrition, Reproduction, Health
- Human Mobility and Location-Based Analysis
- Silkworms and Sericulture Research
- RNA Research and Splicing
- Reproductive Biology and Fertility
- Neurological Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Immune Response and Inflammation
- Animal Virus Infections Studies
- CRISPR and Genetic Engineering
- Moringa oleifera research and applications
- Pluripotent Stem Cells Research
Poultry Research Institute
2011-2024
Zhejiang University
2023-2024
Chinese Academy of Agricultural Sciences
2010-2022
China National Rice Research Institute
2015-2021
Air Force General Hospital PLA
2020
China Agricultural University
2019
Washington State University
2019
General Hospital of Jinan Military Command
2013
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2012
Guizhou University
2011
Feed contributes to over 60 % of the total production costs in poultry industry. Increasing feed prompt geneticists include intake and efficiency as selection goals breeding programs. In present study, we used an F2 chicken population a genome-wide association study (GWAS) detect potential genetic variants candidate genes associated with daily (FI) efficiency, including residual (RFI) conversion ratio (FCR). A 1534 hens from White Leghorn Dongxiang reciprocal cross were phenotyped for...
Egg number (EN), egg laying rate (LR) and age at first (AFE) are important production traits related to in poultry industry. To better understand the knowledge of genetic architecture dynamic EN during whole cycle provide precise positions associated variants for EN, LR AFE, records from 21 72 weeks were collected individually 1,534 F2 hens produced by reciprocal crosses between White Leghorn Dongxiang Blue-shelled chicken, their genotypes assayed chicken 600 K Affymetrix high density...
As a major economic trait in chickens, egg weight (EW) receives widespread interests breeding, production and consumption. However, limited information is available for underlying genetic architecture of longitudinal trend EW. Herein, we measured EWs at nine time points from onset laying to 60 week age, conducted comprehensive genome-wide association studies (GWAS) 1,534 F2 hens derived reciprocal crosses between White Leghorn Dongxiang chickens. Egg weights all ages except the first (FEW)...
Laying records on 1,534 F2 hens, derived from a reciprocal cross between White Leghorns and Dongxiang blue-shelled chickens, were used to estimate genetic parameters for residual feed intake (RFI), conversion ratio (FCR), daily (FI), metabolic BW (MBW), gain (BWG), egg mass (EM) at 37 40 (T1) 57 60 wk age (T2), respectively. Genetic analysis was subsequently conducted with the AI-REML method using an animal model. Estimates heritability of RFI, FCR, FI 0.21, 0.19, 0.20 in T1, 0.29, 0.13,...
Because it serves as the cytoplasm of oocyte and provides a large amount reserves, egg yolk has biological significance for developing embryos. The ovary its hierarchy follicles are main reproductive organs responsible deposition in chickens. However, genetic architecture underlying ovarian follicle weights remains elusive. Here, we measured weight (YW) at 11 age points from onset laying to 72 weeks (FW) (OW) 73 part comprehensive genome-wide association study (GWAS) 1,534 F2 hens derived...
Skeletal problems in layer chickens are gaining attention due to animal welfare and economic losses the egg industry. The genetic improvement of bone traits has been proposed as a potential solution these issues; however, architecture is not well understood. We conducted genome-wide association study (GWAS) on quality using sample 1534 hens genotyped with 600 K Chicken Genotyping Array. Using linear mixed model approach, novel locus close GSG1L, associated femur mineral density (BMD), was...
Eggshell is subject to quality loss with aging process of laying hens, and damaged eggshells result in economic losses eggs. However, the genetic architecture underlying dynamic eggshell remains elusive. Here, we measured traits, including weight (ESW), thickness (EST) strength (ESS) at 11 time points from onset 72 weeks age conducted comprehensive genome-wide association studies (GWAS) 1534 F2 hens derived reciprocal crosses between White Leghorn (WL) Dongxiang chickens (DX). ESWs all ages...
The comb, as a secondary sexual character, is an important trait in chicken. Indicators of comb length (CL), height (CH), and weight (CW) are often selected production. DNA-based marker-assisted selection could help chicken breeders to accelerate genetic improvement for or related economic characters by early selection. Although number quantitative loci (QTL) candidate genes have been identified with advances molecular genetics, underlying traits limited. aim the study was use genome-wide...
The ultrastructure of an eggshell is considered the major determinant quality, which has biological and economic significance for avian poultry industries. However, interrelationships genome-wide architecture remain to be elucidated. Herein, we measured thickness (EST), effective layer (ET), mammillary (MT), density (MD) conducted association studies in 927 F2 hens. SNP-based heritabilities traits were estimated 0.39, 0.36, 0.17 0.19 EST, ET, MT MD, respectively, a total 719, 784, 1 10...
The objectives of the present study were to screen for key gene and signaling pathways involved in production male germ cells poultry investigate effects transforming growth factor beta (TGF-β) pathway on differentiation chicken embryonic stem (ESCs) into cells. ESCs, primordial cells, spermatogonial (SSCs) sorted using flow cytometry RNA sequencing (RNA-seq) technology. Male ESCs induced 40 ng/mL bone morphogenetic protein 4 (BMP4). TGF-β SSCs confirmed by morphology, quantitative real-time...
Abstract Follicular development has a major impact on reproductive performance. Most previous researchers focused molecular mechanisms of follicular development. The genetic architecture underlying the number follicle, however, yet not to be thoroughly defined in chicken. Here we report genome-wide association study for determining numbers follicles large F 2 resource population. results showed heritability were low moderate (0.05–0.28) pre-ovulatory (POF), small yellow (SYF) and atresia...
Bone size is an important trait for chickens because of its association with osteoporosis in layers and meat production broilers. Here, we employed high density genotyping platforms to detect candidate genes bone traits. Estimates the narrow heritabilities ranged from 0.37 ± 0.04 shank length 0.59 tibia length. The dominance heritability was 0.12 Using a linear mixed model approach, identified promising locus within NCAPG on chromosome 4, which associated mass, femur area, In addition, three...
Onset of the rapid gonad growth is a milestone in sexual development that comprises many genes and regulatory factors. The observations model organisms mammals including humans have shown potential link between miRNAs timing. To determine whether play roles this process chicken (Gallus gallus), Solexa deep sequencing was performed to analyze profiles miRNA expression hypothalamus hens from two different pubertal stages, before onset (BO) after (AO). 374 conserved 46 novel were identified as...
Chicken is recognized as an excellent model for studies of genetic mechanism phenotypic and genomic evolution, with large effective population size strong human-driven selection. In the present study, we performed Extended Haplotype Homozygosity (EHH) tests to identify significant core regions employing 600K SNP chip in F2 1,534 hens, which was derived from reciprocal crosses between White Leghorn Dongxiang chicken. Results indicated that a total 49,151 average length 9.79 Kb were...
Albumen quality is a leading economic trait in the chicken industry. Major studies have paid attention to genetic architecture underlying albumen quality. However, putative quantitative locus (QTL) for this still unclear. In genome-wide association study, we used an F2 resource population study longitudinal Seven single-nucleotide polymorphism (SNP) loci were found be significantly ( p<8.43×10-7 ) related by univariate analysis, while 11 SNPs associated with multivariate analysis. A QTL on...
Molecular genetic tools provide a method for improving the breeding selection of chickens (Gallus gallus). Although some studies have identified genes affecting egg quality, little is known about responsible oviduct development. To address this issue, here we used genome-wide association (GWA) study to detect or genomic regions that are related development in chicken F2 resource population by employing high-density 600 K single-nucleotide polymorphism (SNP) arrays. For length and weight,...
There are still no highly sensitive and unique biomarkers for measurement of puberty onset. Circulating miRNAs have been shown to be promising diagnosis various diseases. To identify circulating that could served as measuring chicken (Gallus gallus) onset, the Solexa deep sequencing was performed analyze miRNA expression profiles in serum plasma hens from two different pubertal stages, before onset (BO) after (AO). 197 conserved 19 novel (reads > 10) were identified serum/plasma-expressed...