A5039860353- Photodynamic Therapy Research Studies
- Antioxidant Activity and Oxidative Stress
- DNA and Nucleic Acid Chemistry
- DNA Repair Mechanisms
- Free Radicals and Antioxidants
- Redox biology and oxidative stress
- Electron Spin Resonance Studies
- Carcinogens and Genotoxicity Assessment
- Analytical Chemistry and Sensors
- Porphyrin and Phthalocyanine Chemistry
- bioluminescence and chemiluminescence research
- Nitric Oxide and Endothelin Effects
- Porphyrin Metabolism and Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Mitochondrial Function and Pathology
- Eicosanoids and Hypertension Pharmacology
- Environmental Toxicology and Ecotoxicology
- Nanoplatforms for cancer theranostics
- Analytical Chemistry and Chromatography
- Biochemical effects in animals
- Photoreceptor and optogenetics research
- Photosynthetic Processes and Mechanisms
- Mass Spectrometry Techniques and Applications
- Folate and B Vitamins Research
- Retinoids in leukemia and cellular processes
Universidade de São Paulo
2016-2025
Hospital Universitário da Universidade de São Paulo
2024
Bambino Gesù Children's Hospital
2020
Northwestern University
2020
Universidade Cidade de São Paulo
2000-2018
Instituto de Química y Fisicoquímica Biológicas
2014
Universidade Estadual de Campinas (UNICAMP)
1997-2011
Universidade Estadual Paulista (Unesp)
2011
Instituto de Botânica
1992-2010
Universidade Paulista
1998-2006
Although the general mechanisms of lipid oxidation are known, chemical steps through which photosensitizers and light permeabilize membranes still poorly understood. Herein we characterized products photooxidation their effects on bilayers, also giving insight into formation pathways. Our experimental system was designed to allow two phenothiazinium-based (methylene blue, MB, DO15) deliver same amount singlet oxygen molecules per second 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine...
N1-acetyl-N2-formyl-5-methoxykynuramine (AMFK) is a major metabolite of melatonin in mammals. To investigate whether AFMK exists plants, an aquatic plant, water hyacinth, was used. achieve this, LC/MS/MS with deuterated standard employed. identified any plant for the first time. Both it and its precursor, melatonin, were rhythmic peaks during late light phase. These novel rhythms indicate that these molecules do not serve as chemical signal darkness animals but may relate to processes...
The decomposition of lipid hydroperoxides into peroxyl radicals is a potential source singlet oxygen (1O2) in biological systems. We report herein on evidence the generation 1O2 from involving cyclic mechanism linear tetraoxide intermediate proposed by Russell. Using 18O-labeled linoleic acid hydroperoxide (LA18O18OH) presence Ce4+ or Fe2+, we observed formation (18[1O2]) chemical trapping with 9,10-diphenylanthracene (DPA) and detected corresponding DPA endoperoxide (DPA18O18O)...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuantification of singlet oxygen generated by thermolysis 3,3'-(1,4-naphthylene)dipropionate endoperoxide. Monomol and dimol photoemission the effects 1,4-diazabicyclo[2.2.2]octanePaolo Di Mascio Helmut SiesCite this: J. Am. Chem. Soc. 1989, 111, 8, 2909–2914Publication Date (Print):April 1, 1989Publication History Published online1 May 2002Published inissue 1 April...
The circadian rhythm of melatonin in saliva or plasma, the metabolite 6-sulfatoxymelatonin (a6MTs) urine, is a defining feature suprachiasmatic nucleus (SCN) function, body's endogenous oscillatory pacemaker. primary objective this review to ascertain clinical benefits and limitations current methodologies employed for detection quantification biological fluids tissues.A search English-language literature (Medline) systematic published articles were carried out.Articles that specified both...
Protecting human skin from sun exposure is a complex issue that involves unclear aspects of the interaction between light and tissue. A persistent misconception visible safe for skin, although several lines evidence suggest otherwise. Here, we show can damage melanocytes through melanin photosensitization singlet oxygen (1O2) generation, thus decreasing cell viability, increasing membrane permeability, causing both DNA photo-oxidation necro-apoptotic death. UVA (355 nm) (532 photosensitize...
Abstract Glucose modulates plant metabolism, growth, and development. In Arabidopsis (Arabidopsis thaliana), Hexokinase1 (HXK1) is a glucose sensor that may trigger abscisic acid (ABA) synthesis sensitivity to mediate glucose-induced inhibition of seedling Here, we show the intensity short-term responses can vary with ABA activity. We report transient (2 h/4 h) repression by 2% AtbZIP63, gene encoding basic-leucine zipper (bZIP) transcription factor partially involved in Snf1-related kinase...