A5032987140- Cancer Cells and Metastasis
- Cell Adhesion Molecules Research
- Genomics and Phylogenetic Studies
- Hippo pathway signaling and YAP/TAZ
- Caveolin-1 and cellular processes
- Extracellular vesicles in disease
- Sirtuins and Resveratrol in Medicine
- CRISPR and Genetic Engineering
- FOXO transcription factor regulation
- Plant Disease Resistance and Genetics
- Lung Cancer Research Studies
- User Authentication and Security Systems
- MicroRNA in disease regulation
- Microtubule and mitosis dynamics
- Handwritten Text Recognition Techniques
- Plant Pathogens and Resistance
- Pluripotent Stem Cells Research
- Alzheimer's disease research and treatments
- Refrigeration and Air Conditioning Technologies
- Immune cells in cancer
- Insect symbiosis and bacterial influences
- Plant-Microbe Interactions and Immunity
- Gastrointestinal Tumor Research and Treatment
- Congenital heart defects research
- Exercise and Physiological Responses
Japanese Foundation For Cancer Research
2024-2025
Kumamoto University
2019-2025
Tokyo University of Science
2022
Tottori University
2022
Tokyo University of Agriculture and Technology
2022
Ibaraki University
2015
Hitachi (Japan)
2015
<title>Abstract</title> Reversible histone acylation is crucial for epigenetic gene expression regulation. Histone typically mediated by lysine acyltransferases (KATs), which use acyl-CoAs as acyl donors. Here, we revealed the novel role of deacetylases HDAC1 and HDAC2 in catalysis. Notably, show that directly catalyze sorbylation using sorbic acid, a common food preservative, addition to facilitating desorbylation. This newly discovered HDAC1/2-driven function distinctive active mark leads...
Forkhead box O (FOXO) family proteins are expressed in various cells, and play crucial roles cellular metabolism, apoptosis, aging. FOXO1-null mice exhibit embryonic lethality due to impaired endothelial cell (EC) maturation vascular remodeling. However, FOXO1-mediated genome-wide regulation ECs remains unclear. Here, we demonstrate that VEGF dynamically regulates FOXO1 cytosol-nucleus translocation. re-localizes the nucleus via PP2A phosphatase. RNA-seq combined with...
Brown adipose tissue plays a central role in the regulation of energy balance by expending to produce heat. NAD+-dependent deacylase sirtuins have widely been recognized as positive regulators brown thermogenesis. However, here we reveal that SIRT7, one seven mammalian sirtuins, suppresses expenditure and thermogenesis regulating functions. Whole-body tissue-specific Sirt7 knockout mice higher body temperature expenditure. SIRT7 deficiency increases protein level UCP1, key regulator...
Abstract Background: Multiplex immunostaining techniques have been actively developed and recently become more prevalent in cancer research. However, most of these require specialized instruments customized primary antibodies. Here, we established a simple versatile workflow for multiplex immunohistochemistry (IHC) named RePROBE (Repetitive Primary antibody Replacement Overlaying images from Broad range fluorescence imaging Equipment) that can be readily adopted many laboratories, providing...
Abstract Tumor-initiating cells are key players in driving chemoresistance and metastasis, making them promising targets for cancer therapy. However, the identity of tumor-imitating molecular mechanisms underlying their capacity human pancreatic ductal adenocarcinoma (PDAC) remains unclear. To address this, we conducted single-cell RNA sequencing functional studies PDAC xenografts to identify targetable tumor-initiating cells. We found that a subpopulation characterized by partial...
Abstract Colorectal cancer demonstrates intra-tumour heterogeneity formed by a hierarchical structure comprised of stem cells (CSCs) and their differentiated progenies. The mechanism which CSCs are maintained needs to be further elucidated, there is evidence that the tumour microenvironment governs stemness. Using PLR123, colon cell line with CSC properties, we determined culture conditions necessary establish pair three-dimensional (3D) models grown in Matrigel, designated stemCO diffCO....
Alzheimer's disease (AD) is an age-related neurodegenerative that characterized by irreversible memory loss and cognitive decline. The deposition of amyloid-β (Aβ), especially aggregation-prone Aβ42, considered to be early event preceding neurodegeneration in AD. Sirtuins (SIRT1-7 mammals) are nicotinamide adenine dinucleotide-dependent lysine deacetylases/deacylases, several sirtuins play important roles However, the involvement SIRT7 AD pathogenesis not known. Here, we demonstrate mRNA...
Abstract Fusarium species include important filamentous fungal pathogens that can infect plants, animals, and humans. Meanwhile, some nonpathogenic are promising biocontrol agents against plant pathogens. Here, we developed a genome editing technology using vector-based CRISPR/Cas9 system for oxysporum f. sp. lycopersici ( Fol ). This optimized system, harboring an endogenous U6 small nuclear RNA promoter the expression of single-guide H2B localization signal Cas9, enabled efficient targeted...
Abstract Filamentous fungi have evolved compartmentalized genomes consisting of conserved core regions and dynamic accessory regions, which aid the adaptation to changing environments including interaction with host organisms. In Fusarium oxysporum species complex, play an important role during infection it has been reported that these undergo extensive duplications, however, is currently unknown how such duplications shape regions. Moreover, function apart from encoding virulence effectors...
We focused on Content Centric Networking (CCN) of the next generation network. CCN is technology for which data reused over whole network by storing cache in each router. In this paper, we propose information acquisition method utilizing a time large scale natural disaster. attempted comparison between IP and simulator. comparative verification, established hit ratio, number hops, as evaluation item. On could confirm utility CCN. has great potential that various can be provided to victims...
Abstract The receptor tyrosine kinase-like orphan 1 (ROR1) regulates caveolae formation and caveolae-dependent endocytosis by interacting with components, which in turn sustains pro-survival signaling toward AKT from multiple RTKs, including EGFR, MET. We report here a novel function of ROR1 as scaffold for HRS STAM1, two essential components ESCRT-0. present results show that facilitates interactions thereby preventing the lysosomal degradation HRS. Furthermore, interaction STAM1 was found...
Abstract Fusarium species include important filamentous fungal pathogens that can infect plants, animals, and humans. Meanwhile, some nonpathogenic are promising biocontrol agents against plant pathogens. Here, we developed a genome editing technology using vector-based CRISPR/Cas9 system for oxysporum f. sp. lycopersici ( Fol ). This optimized system, harboring an endogenous U6 small nuclear RNA promoter the expression of single-guide H2B localization signal Cas9, enabled efficient targeted...
Abstract Tumor-initiating cells are the major drivers of chemoresistance and relapse, making them attractive targets for cancer therapy. However, identity tumor- initiating in human pancreatic ductal adenocarcinoma (PDAC) key molecules underlying their traits remain poorly understood. Here, we show that a partial epithelial-mesenchymal transition (EMT)-like subpopulation marked by high expression receptor tyrosine kinase-like orphan 1 (ROR1) is origin heterogeneous tumor PDAC. We demonstrate...