A5072059154- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Pluripotent Stem Cells Research
- Pharmacogenetics and Drug Metabolism
- Tissue Engineering and Regenerative Medicine
- CRISPR and Genetic Engineering
- Organ Transplantation Techniques and Outcomes
- Pancreatic function and diabetes
- Drug Transport and Resistance Mechanisms
- Lipid metabolism and disorders
- Endoplasmic Reticulum Stress and Disease
- Diet, Metabolism, and Disease
- Alcohol Consumption and Health Effects
- Liver Diseases and Immunity
University of Pittsburgh
2021-2023
Metabolic-dysfunction-associated steatotic liver disease (MASLD), which affects 30 million people in the US and is anticipated to reach over 100 by 2030, places a significant financial strain on healthcare system. There presently no FDA-approved treatment for MASLD despite its public health significance burden. Understanding connection between point mutations, enzymes, important comprehending drug toxicity healthy or diseased individuals. Multiple genetic variations have been linked...
A.S.-G is an inventor on a patent application that describes the use of transcription factors to treat chronic liver failure (US20140249209).E.N.T. and A.S.-G., are inventors provisional related methods enhance hepatic functions in human failing livers
Abstract The initial creation of human‐induced pluripotent stem cells (iPSCs) set the foundation for future regenerative medicine. Human iPSCs can be differentiated into a variety cell types in order to study normal and pathological molecular mechanisms. Currently, there are well‐defined protocols differentiation, characterization, establishment functionality human iPSC‐derived hepatocytes (iHep) cholangiocytes (iCho). Electrophysiological on chloride ion efflux channel activity iHep iCho...
Although the underlying cause may vary across countries and demographic groups, liver disease is a major of morbidity mortality globally. Orthotopic transplantation only definitive treatment for failure but limited by lack donor livers. The development drugs that prevent progression generation alternative constructs could help alleviate burden disease. Bioengineered livers containing human induced pluripotent stem cell (iPSC)-derived cells are being utilized to study identify test potential...