A5003063613- CAR-T cell therapy research
- Advancements in Semiconductor Devices and Circuit Design
- Electrospun Nanofibers in Biomedical Applications
- Integrated Circuits and Semiconductor Failure Analysis
- Bone Tissue Engineering Materials
- Membrane Separation Technologies
- Cardiac Structural Anomalies and Repair
- Silk-based biomaterials and applications
- Antifungal resistance and susceptibility
- Nanomaterials for catalytic reactions
- Peptidase Inhibition and Analysis
University of Pennsylvania
2022-2023
University of Puerto Rico System
2022
University of Puerto Rico at Río Piedras
2022
California Institute for Regenerative Medicine
2022
Fibrosis affects millions of people with cardiac disease. We developed a therapeutic approach to generate transient antifibrotic chimeric antigen receptor (CAR) T cells in vivo by delivering modified messenger RNA (mRNA) cell–targeted lipid nanoparticles (LNPs). The efficacy these vivo–reprogrammed CAR was evaluated injecting CD5-targeted LNPs into mouse model heart failure. Efficient delivery mRNA encoding the lymphocytes observed, which produced transient, effective vivo. Antifibrotic...
In the last decades, cell-based approaches for bone tissue engineering (BTE) have relied on using models that cannot replicate complexity of microenvironment. There is an ongoing amount research scaffold development responding to need feasible materials can mimic extracellular matrix (ECM) and aid regeneration (BTR). this work, a porous cellulose acetate (CA) fiber mat was developed electrospinning technique mats were chemically modified bioactivate their surface promote osteoconduction...
Polyphenols are natural compounds with strong antioxidant properties synthesized by plants and widely distributed in plant tissues. They compose a broad class of that commonly employed for multiple applications such as food, pharmaceutical, adhesives, biomedical, agricultural, industrial purposes. Runoffs from these sources result the introduction polyphenols into aquatic environments where they further transform highly toxic pollutants can negatively affect ecosystems humans. Therefore,...
Fibroblast activation protein (FAP) is a marker of activated fibroblasts in various human cardiovascular diseases. FAP special interest because it expressed exclusively activated, pathogenic and has been proposed as target for chimeric antigen receptor (CAR) T cell ablation therapy. It shown previously that from patients with hypertrophic dilated cardiomyopathy express FAP, while non-failing hearts did not. The aim the project was to examine expression other cardiac diseases by obtaining...