A5086651725- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism, Diabetes, and Cancer
- Chronic Disease Management Strategies
- Diabetes and associated disorders
- Diabetes Management and Research
- Diabetes Treatment and Management
- Health and Medical Studies
- Health Promotion and Cardiovascular Prevention
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 and healthcare impacts
- Health disparities and outcomes
- Climate Change and Health Impacts
- Chronic Kidney Disease and Diabetes
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Management and Education
- Pain Mechanisms and Treatments
- Electromagnetic Fields and Biological Effects
- Risk Perception and Management
- COVID-19 epidemiological studies
- Botulinum Toxin and Related Neurological Disorders
- Venous Thromboembolism Diagnosis and Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Blood Pressure and Hypertension Studies
- Sleep and related disorders
- Global Health Care Issues
Institut für Medizinische Informatik, Biometrie und Epidemiologie
2015-2025
Essen University Hospital
2016-2025
University of Duisburg-Essen
2016-2025
Zimmer Biomet (Germany)
2010-2021
Deutsches Diabetes-Zentrum e.V.
2010-2015
Heinrich Heine University Düsseldorf
2010-2015
German Center for Diabetes Research
2013-2015
Ruhrlandklinik
2015
Bielefeld University
2006-2011
Diabetes Research Center
2010
Objective: The aim of this first phase a cross-sectional study from Germany was to investigate whether proximity residence mobile phone base stations as well risk perception is associated with health complaints. Methods: researchers conducted population-based, multi-phase, within the context large panel survey regularly carried out by private research institute in Germany. In initial phase, reported on paper, 30 047 persons total 51 444 who took part nationwide also answered questions how...
ObjectivesThe first wave of the SARS-CoV-2 pandemic in Germany lasted from week 10 to 23 2020. The aim is provide estimates excess mortality during this time.MethodsWe analyzed age-specific numbers deaths per 2016 26 We used weekly mean 2016–2019 estimate expected for estimated standardized ratios (SMR) and 95% confidence intervals.ResultsDuring observed were higher than age groups 60–69, 80–89, 90+. group 70–79 years did not show mortality. net number weeks 10–23 was +8,071. overall SMR...
Background In observational studies, a lower cancer risk was reported for patients with diabetes using metformin. However, many of these studies had shortcomings like time-related biases. We aimed to compare the incidence rate any and some selected sites in metformin, sulfonylurea, insulin users reduce major biases common studies. Methods retrospective database study, we used patient data from general practices throughout Germany UK. Eighty thousand two hundred sixty-three aged 30–89 years...
The aim of the cross-sectional study was to test hypothesis that exposure continuous low-level radio frequency electromagnetic fields (RF-EMFs) emitted from mobile phone base stations related various health disturbances.For investigation people living mainly in urban regions were selected a nationwide 2006. In total, 3526 persons responded questionnaire (response rate 85%). For assessment dosimeter measuring different RF-EMF frequencies used. Participants answered postal on how affected...
The metabolic syndrome is a major public health challenge and identifies persons at risk for diabetes cardiovascular disease. aim of this study was to examine the association between age menarche (IDF NCEP ATP III classification) its components.1536 women aged 32 81 years German population based KORA F4 were investigated. Data collected by standardized interviews, physical examinations, whole blood serum measurements.Young significantly associated with elevated body mass index (BMI), greater...
Distal sensorimotor polyneuropathy (DSPN) is a severe complication of type 2 diabetes. This study aimed to assess the prevalence unawareness DSPN in prediabetes and diabetes sample older population Augsburg, Germany.Glucose tolerance status was determined 61- 82-year-old participants population-based KORA F4 Study (2006-2008) (n = 1,100). Clinical defined as presence bilaterally impaired foot-vibration perception and/or foot-pressure sensation. case subjects were considered unaware their...
Inflammatory processes have been implicated in the pathogenesis of diabetic distal sensorimotor polyneuropathy (DSPN), but their possible relationship has not assessed at population level.We determined serum concentrations mediators subclinical inflammation among 1,047 participants 61-82 years age from population-based Cooperative Health Research Region Augsburg (KORA) F4 study (Germany). Logistic and linear regression models were fitted to assess associations between immune...
Early detection of diabetes and prediabetic states is beneficial for patients, but may be delayed by patients´ being overly optimistic about their own health. Therefore, we assessed how persons without known perceive risk having or developing diabetes, identified factors associated with perception risk.1,953 participants previously from the population-based, German KORA FF4 Study (59.1 years, 47.8% men) had an oral glucose tolerance test. They estimated probability undiagnosed mellitus (UDM)...
Reduced circulating omentin levels have been reported in obesity and type 2 diabetes, but data were mostly derived from univariate analyses small study samples. This aimed to investigate the relationship between omentin, abnormal glucose tolerance related metabolic factors a large population-based cross-sectional study.Serum was measured by ELISA 1092 participants of German KORA F4 survey (2006-2008). Associations serum levels, (assessed with an oral test) diabetes-related estimated using...
Introduction Excess mortality is a suitable indicator of health consequences COVID-19 because death from any cause clearly defined contrary to Covid-19. We compared the overall in 2020 with 2016 2019 Germany, Sweden and Spain. Contrary other studies, we also took demographic development between increasing life expectancy into account. Methods Using population figures EUROSTAT database, estimated weekly cumulative Standardized Mortality Ratios (SMR) 95% confidence intervals (CI) for year...
The worldwide severe acute respiratory syndrome coronavirus 2 pandemic challenges adolescents' mental health. In this study, we aim to compare the number of pediatric ICU (PICU) admissions after suicide attempts during first German lockdown and one year later a second, prolonged with prepandemic years.A retrospective multicenter study was conducted among 27 PICUs. Cases <18 years admitted PICU because accidents or injuries between March 16 May 31 2017 2021 were identified based on...
The aim of this publication is to demonstrate similarities and differences in the association risk factors with prevalence different manifestations chronic venous disease (CVD), like varicose veins (VV), oedema (C3) severe insufficiency (CVI) population-based cross-sectional Bonn Vein Study 1 (BVS).
Diabet. Med. 27, 1116–1123 (2010) Abstract Background The aim was to derive Type 2 diabetes prediction models for the older population and check what degree addition of 2‐h glucose measurements (oral tolerance test) biomarkers improves predictive power risk scores which are based on non‐biochemical as well conventional clinical parameters. Methods Oral tests were carried out in a population‐based sample 1353 subjects, aged 55–74 years (62% response) Augsburg (Southern Germany) from 1999...
We examined the association between retinol-binding protein 4 (RBP4), a novel adipokine, and prediabetes (isolated impaired fasting glucose [i-IFG], isolated tolerance [i-IGT], combined IFG IGT) in men women aged 32-81 years.The analysis was based on 2,614 participants without previously diagnosed diabetes those with newly of Cooperative Health Research Region Augsburg (KORA) F4 Study, conducted from 2006 to 2008 southern Germany. Plasma RBP4 analyzed by immunonephelometry.In logistic...
Abstract Aim To examine associations of pre‐diabetes and well‐controlled diabetes with periodontitis. Materials Methods The Study Health in Pomerania ( SHIP )‐Trend is a cross‐sectional survey North‐Eastern Germany including 3086 participants (49.4% men; age 20–82 years). Clinical attachment loss CAL ) periodontal probing depth PPD were assessed applying random half‐mouth protocol. number teeth was determined. Pre‐diabetes comprised impaired fasting glucose tolerance. Previously known...
To assess the prevalence of distal sensorimotor polyneuropathy (DSPN) in an older population and to examine its relationship with prediabetes.Glucose tolerance status was determined 61- 82-year-old participants (n = 1,100) population-based Cooperative Health Research Region Augsburg (KORA) F4 Survey (2006-2008). Clinical DSPN defined as bilaterally impaired foot-vibration perception and/or foot-pressure sensation.Prevalence clinical similar subjects known diabetes (22.0%) combined fasting...
Several meta-analyses of observational studies suggested that metformin use reduces cancer risk in type 2 diabetes. However, this result was not confirmed by the few available randomized controlled trials (RCTs), and many on were potentially afflicted with time-related bias. We aimed to avoid bias when comparing incidence users sulfonylurea, insulin, other diabetes medications, respectively, users.In a retrospective study, we used German Disease Analyzer database patient data from general...