A5057550134- Phytochemicals and Antioxidant Activities
- Antioxidant Activity and Oxidative Stress
- Tea Polyphenols and Effects
- Vitamin C and Antioxidants Research
- Free Radicals and Antioxidants
- Natural Antidiabetic Agents Studies
- Adipose Tissue and Metabolism
- Eicosanoids and Hypertension Pharmacology
- Diet, Metabolism, and Disease
- Nitric Oxide and Endothelin Effects
- Hormonal Regulation and Hypertension
- Adipokines, Inflammation, and Metabolic Diseases
- Trace Elements in Health
- Gut microbiota and health
- Pesticide Exposure and Toxicity
- Digital Holography and Microscopy
- Renin-Angiotensin System Studies
- Genomics, phytochemicals, and oxidative stress
- Cardiac Ischemia and Reperfusion
- Natural product bioactivities and synthesis
- Biochemical Analysis and Sensing Techniques
- Cardiac Arrest and Resuscitation
- Non-Destructive Testing Techniques
- Nutrition, Genetics, and Disease
- Liver Disease Diagnosis and Treatment
University of California, Davis
2016-2025
University of Buenos Aires
2015-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2015-2024
Peking University
2023
Royal Society of Chemistry
2023
The University of Western Australia
2023
University of Leeds
2023
University of Guelph
2023
TiFN
2023
University of Namur
2023
Oxidative damage to DNA is shown be extensive and could a major cause of the physiological changes associated with aging degenerative diseases related such as cancer. The oxidized nucleoside, 8-hydroxy-2'-deoxyguanosine (oh8dG), one approximately 20 known oxidative products, has been measured in isolated from various organs Fischer 344 rats different ages. oh8dG was present all studied: liver, brain, kidney, intestine, testes. Steady-state levels ranged 8 73 residues per 10(6) deoxyguanosine...
Damage to the DNA of germ cells can lead mutation, which may result in birth defects, genetic diseases, and cancer. The very high endogenous rate oxidative damage importance dietary ascorbic acid (AA) preventing this has prompted an examination these factors human sperm DNA. oxidized nucleoside 8-hydroxy-2'-deoxyguanosine (8-oxo-7,8-dihydro-2'-deoxyguanosine; oxo8dG), 1 approximately 20 major products DNA, was measured isolated from provided by healthy subjects compared seminal fluid AA...
Flavonoids can exert beneficial health effects through multiple mechanisms. In this paper, we address the important, although not fully understood, capacity of flavonoids to interact with cell membranes. The interactions polyphenols bilayers include: (a) partition more non‐polar compounds in hydrophobic interior membrane, and (b) formation hydrogen bonds between polar head groups lipids hydrophilic at membrane interface. consequences these are discussed. induction changes physical properties...
Angiotensin converting enzyme (ACE) activity was evaluated in the presence of flavanol-rich foods, i.e., wines, chocolates, and teas, purified flavonoids. All foods assayed inhibited ACE activity, red wines being more effective than white wine, green tea black tea. The inhibition associated with both phenolic flavanol content foods. When isolated polyphenols were assayed, procyanidins (dimer hexamer) epigallocatechin significantly activity; similar concentrations (+)-catechin,...
It was determined that flavan-3-ols and procyanidins have an inhibitory effect on angiotensin I converting enzyme (ACE) activity, the dependent number of epicatechin units forming procyanidin. The inhibition by competitive with two substrates assayed: N-hippuryl-L-histidyl-L-leucine (HHL) N-[3-(2-furyl)acryloyl]-L-phenylalanylglycylglycine (FAPGG). Tetramer hexamer fractions were more potent inhibitors, showing Ki 5.6 4.7 microM, respectively. As ACE is a membrane protein, interaction...
Twenty six phenolic substances including representatives of the families, flavanones, flavanols and procyanidins, flavonols, isoflavones, acids phenylpropanones were investigated for their effects on lipid oxidation, membrane fluidity integrity. The incubation synthetic phosphatidylcholine (PC) liposomes in presence these phenolics caused following effects: (a) flavanols, related procyanidins flavonols most active preventing 2,2′-azo-bis (2,4-dimethylvaleronitrile) (AMVN)-induced...