A5000312223- Microbial Metabolic Engineering and Bioproduction
- Plant biochemistry and biosynthesis
- Microbial Natural Products and Biosynthesis
- Biofuel production and bioconversion
- Enzyme Catalysis and Immobilization
- Bacterial Genetics and Biotechnology
- CRISPR and Genetic Engineering
- RNA and protein synthesis mechanisms
- Viral Infectious Diseases and Gene Expression in Insects
- Gene Regulatory Network Analysis
- Fungal and yeast genetics research
- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- Bacteriophages and microbial interactions
- Enzyme Structure and Function
- Microbial Fuel Cells and Bioremediation
- Photosynthetic Processes and Mechanisms
- Wastewater Treatment and Nitrogen Removal
- Metabolomics and Mass Spectrometry Studies
- biodegradable polymer synthesis and properties
- Fungal Biology and Applications
- Plant Gene Expression Analysis
- Biochemical and biochemical processes
- Chromium effects and bioremediation
- Innovative Microfluidic and Catalytic Techniques Innovation
Lawrence Berkeley National Laboratory
2016-2025
University of California, Berkeley
2016-2025
Joint BioEnergy Institute
2016-2025
Novo Nordisk Foundation
2016-2025
Technical University of Denmark
2016-2025
QB3
2016-2025
Berkeley College
2013-2024
Shenzhen Institutes of Advanced Technology
2018-2024
Chinese Academy of Sciences
2020-2024
State Key Laboratory of Synthetic Chemistry
2024
Malaria, caused by Plasmodium sp, results in almost one million deaths and over 200 new infections annually. The World Health Organization has recommended that artemisinin-based combination therapies be used for treatment of malaria. Artemisinin is a sesquiterpene lactone isolated from the plant Artemisia annua. However, supply price artemisinin fluctuate greatly, an alternative production method would valuable to increase availability. We describe progress toward goal developing...
Rising petroleum costs, trade imbalances and environmental concerns have stimulated efforts to advance the microbial production of fuels from lignocellulosic biomass. Here we identify a novel biosynthetic alternative D2 diesel fuel, bisabolane, engineer platforms for its immediate precursor, bisabolene. First, bisabolane as an by measuring fuel properties chemically hydrogenated commercial Then, via combination enzyme screening metabolic engineering, obtain more than tenfold increase in...
Increasing energy costs and environmental concerns have motivated engineering microbes for the production of "second generation" biofuels that better properties than ethanol.Saccharomyces cerevisiae was engineered with an n-butanol biosynthetic pathway, in which isozymes from a number different organisms (S. cerevisiae, Escherichia coli, Clostridium beijerinckii, Ralstonia eutropha) were substituted Clostridial enzymes their effect on compared. By choosing appropriate isozymes, we able to...
As engineered biological systems become more complex, it is increasingly common to express multiple operons from different plasmids and inducible expression within a single host cell. Optimizing such often requires screening combinations of origins replication, systems, antibiotic markers. This procedure hampered by lack quantitative data on how these components behave when than one origin replication or system are used simultaneously. Additionally, this process can be time consuming as the...
Standard biological parts, such as BioBricks™ provide the foundation for a new engineering discipline that enables design and construction of synthetic systems with variety applications in bioenergy, materials, therapeutics, environmental remediation. Although original assembly standard has found widespread use, it several shortcomings limit its range potential applications. In particular, system is not suitable protein fusions due to an unfavorable scar sequence encodes in-frame stop codon....