A5064689115- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Renal Transplantation Outcomes and Treatments
- Hematological disorders and diagnostics
- IL-33, ST2, and ILC Pathways
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Organ Transplantation Techniques and Outcomes
- Blood disorders and treatments
- Neutropenia and Cancer Infections
- Pancreatic function and diabetes
- Biological Stains and Phytochemicals
- Pneumocystis jirovecii pneumonia detection and treatment
- 14-3-3 protein interactions
- Pediatric Pain Management Techniques
- Cytomegalovirus and herpesvirus research
- Transplantation: Methods and Outcomes
- Biomedical Ethics and Regulation
- Organ and Tissue Transplantation Research
- Maternal and fetal healthcare
- Occupational and environmental lung diseases
- Polyomavirus and related diseases
- Organ Donation and Transplantation
Princess Margaret Cancer Centre
2022-2025
University of Toronto
2023-2025
University Health Network
2023-2024
University of Chile
2023-2024
Weatherford College
2023
National Cancer Centre Japan
2023
Hospital Clínic de Barcelona
2023
Costa Rican Department of Social Security
2016-2021
Instituto de Salud Pública de Chile
2019
Auxilio Mutuo Hospital
2006
Post-transplant cyclophosphamide (PTCy) is a promising graft-versus-host disease (GvHD) prophylaxis in haploidentical and matched unrelated donor hematopoietic stem cell transplantation (HSCT), but its role sibling (MSD) transplants remains unclear.We conducted retrospective study of 413 MSD-HSCT patients receiving peripheral blood (PBSC) grafts from January 2010 to 2023. Patients were categorized into four groups: Group I (CNI + MTX or MMF), II MMF ATG), III (PTCy ATG CNI), IV CNI MMF)....
Clinical outcome disparities among racial and ethnic groups have been described following allogeneic hematopoietic cell transplantation (HCT). This study investigated the impact of race ethnicity on HCT outcomes in a multi-ethnic single-center population. We analyzed 709 patients, stratified by groups, who underwent between January 2018 April 2022. Outcomes examined included overall survival (OS), cumulative incidence relapse (CIR), non-relapse mortality (NRM), graft-versus-host...
Introduction Hematological malignancies and allogeneic hematopoietic cell transplantation (alloHCT) often necessitate the use of opioids due to significant pain. This study aimed investigate impact opioid on clinical outcomes patients undergoing alloHCT. Methods A retrospective cohort was conducted by merging data from our local transplant database with anonymized pharmacy records obtained Institute for Clinical Evaluative Sciences (ICES). We analyzed 681 who underwent alloHCT at Princess...
ABSTRACT Myelodysplastic/myeloproliferative overlap neoplasms (MDS/MPN) are rare hematological malignancies. We analyzed the outcomes of 75 patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) for MDS/MPN. Graft‐versus‐host disease (GvHD) prophylaxis included post‐transplantation cyclophosphamide (PTCy) in 71% patients, with 44 (59%) receiving a combination anti‐thymocyte globulin (ATG) and PTCy. The median follow‐up was 44.4 months. Primary graft failure occurred...
Abstract Introduction The literature comparing outcomes between myeloablative (MAC) and reduced intensity conditioning (RIC) for acute myeloid leukemia (AML) is conflicting. Methods We retrospectively analyzed 451 patients who underwent allogenic hematopoietic cell transplantation (alloHCT) AML in complete remission (CR) with either RIC ( n = 331) or MAC 120) the use of dual T‐cell depletion as graft‐versus‐host disease (GVHD) prophylaxis. Results Univariate analysis demonstrated nonrelapse...
La placenta es un órgano complejo encargado de la secreción hormonas y enzimas, realiza el transporte nutrientes productos metabólicos permite intercambio gases. Con aumen-to edad materna las cesáreas, inci-dencia previa acretismo placen-tario se ha elevado, convirtiéndose ambas condi-ciones en problemas para obstetricia moderna. refiere a una implantación placentaria segmento uterino bajo, ya sea muy cerca o con algún grado cobertura del orificio cervical interno. Suele presentarse como...
Cancer remains one of the most important diseases in public health.
Abstract IL-10 producing group 2 innate lymphoid cells (ILC2 10 ) have immunoregulatory functions, and limit harmful immune responses across various tissues. Despite their crucial roles in maintaining homeostasis, the cell therapy potential of human ILC2 has not been demonstrated, due to both limited numbers peripheral blood lack definitive markers for identification. Here, we isolate expand circulating , assess a humanized model Graft-versus-Host Disease (GVHD). Cell with decreased GVHD...
Heffering-Cardwell, Michele RN; Alfaro Moya, Tommy MD; Tinker, Lisa Garmaise, Carole LLB; Bell, Jennifer A.H. PhD; Clarke, Susan Kumar, Rajat Mattsson, Jonas MD, PhD Author Information
Chromobacterium violaceum and Corynebacterium jeikeium are saprophyte bacteria, observed human infections that can be very serious. C. is a gram negative, facultative anaerobe, oxidase catalase positive bacillus found in both aquatic soil environments. The exposure to water and/or among the factors within clinical history of affected patients. jeikeum gram-positive pleomorphic coryneform family, present flora cause different forms infection patients with risk co-morbidities including...
Background : Cancer is one of the most significant non-transmissible diseases at public health level, and febrile neutropenia (FN) its serious life threatening complications. Objective: To estimate 5-year survival rates for children with cancer FN from a referral center in Santiago, Chile, by clinical-demographic variables. Method: Prognostic analytic historical cohort study. (FONDECYT nº 1090194, 2009-2011). Results: 116 subjects were included, grouped three categories, type cancer: 1)...