A5040338839- Mathematical Biology Tumor Growth
- Angiogenesis and VEGF in Cancer
- Single-cell and spatial transcriptomics
- Nanoplatforms for cancer theranostics
- Gene Regulatory Network Analysis
- Anesthesia and Pain Management
- Cancer, Hypoxia, and Metabolism
- Retinal Imaging and Analysis
- Lung Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Retinal Diseases and Treatments
- Axon Guidance and Neuronal Signaling
- Mesenchymal stem cell research
- Cancer Treatment and Pharmacology
- Nausea and vomiting management
- Acute Kidney Injury Research
- Cancer Cells and Metastasis
- Cardiovascular Function and Risk Factors
- Cardiac, Anesthesia and Surgical Outcomes
- Salivary Gland Tumors Diagnosis and Treatment
- Lung Cancer Research Studies
- Spine and Intervertebral Disc Pathology
- Cardiovascular and exercise physiology
- Dendrimers and Hyperbranched Polymers
- Sarcoma Diagnosis and Treatment
Johns Hopkins Medicine
2023
Johns Hopkins University
2023
University of Virginia
2013-2018
Brigham and Women's Hospital
2007-2009
Boston University
2009
Wake Forest University
1996
University of California San Diego Medical Center
1975
Queen Elizabeth Hospital Birmingham
1974
Nanoparticles are finding increased uses in drug delivery applications as a means to increase treatment efficacy and improve patient care. Here, we report engineered polymeric nanoparticles that undergo hydrophobic hydrophilic transition at pH 5 afford swelling rapid release of their contents. As our clinical interest lies the prevention lung tumor recurrence following resection, were evaluated model mimicking microscopic disease, akin residual occult can remain resection margin surgery....
In developing blood vessel networks, the overall level of branching often correlates with angiogenic sprout initiations, but in some pathological situations, increased initiations paradoxically lead to reduced and impaired vascular function. We examine hypothesis that defects discrete stages angiogenesis can uniquely contribute outcomes. Time-lapse movies mammalian development were used define quantify dynamics sprouting. characterized formation new functional conduits by classifying...
We developed an agent-based model of endothelial sprout initiations based on time-lapse confocal imaging <italic>in vitro</italic> that outperforms Monte Carlo simulations, suggesting location and frequency are not purely stochastic behaviors.
Define a role for perivascular cells during developmental retinal angiogenesis in the context of EC Notch1-DLL4 signaling at multicellular network level.The vasculature is highly sensitive to growth factor-mediated intercellular signaling. Although has been explored detail, it remains unclear how PC function modulate these signals that lead diverse set vascular patterns health and disease. We have developed an ABM incorporates both ECs PCs investigate formation as pericyte coverage. use our...
Previous studies have shown that exposure to a hypoxic in vitro environment increases the secretion of pro-angiogenic growth factors by human adipose-derived stromal cells (hASCs) [Cao Y, et al., Biochem Biophys Res Commun 332: 370–379, 2005; Kokai LE, Plast Reconstr Surg 116: 1453–1460, Park BS, Biomed (Tokyo) 31: 27–34, 2010; Rasmussen JG, Cytotherapy 13: 318–328, Rehman J, Circulation 109: 1292–1298, 2004]. Previously, it has been demonstrated hASCs can differentiate into pericytes and...
The management of a patient is described who has blood patch for spinal headache, but had recurrence symptoms 1 day later which was successfully treated by second patch. A case in there dural puncture immediately prior to the and, following patch, complained severe debilitating 'paralysing' pain both legs. This short duration and successful. Some further observations on use are recorded.
7593 Background: Surgical resection remains the most effective treatment for patients with non-small cell lung cancer; however, even in early stage diagnoses presence of occult microscopic disease at surgical margin significantly impacts long-term patient survival. Thus, focus this study is to establish proof concept that locoregional growth tumor burden can be prevented through application a novel “expansile” nanoparticle drug delivery system. Methods: Biocompatible polymer nanoparticles...
Differences in exercise blood lactate (LA) responses between Congestive Heart Failure (CHF) patients and normal (NL) subjects have been reported. However, these results observed mostly younger CHF with left ventricular (LV) systolic dysfunction (SD). In the elderly, primarily due to LV diastolic (DD) is nearly as common SD. Therefore, we compared LA response elderly SD(n=16, 67.1±0.7yrs) vs. DD (n=16, 68.8±1.6yrs) 9 aged-matched NL (67.7±2.4yrs) during symptom-limited maximal cycle...