A5083983400- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Cardiac Structural Anomalies and Repair
- Infective Endocarditis Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Congenital Heart Disease Studies
- Cardiac Arrhythmias and Treatments
- Cardiovascular Effects of Exercise
- Cardiovascular Disease and Adiposity
- Cardiac and Coronary Surgery Techniques
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac pacing and defibrillation studies
- Advanced battery technologies research
- Diabetes Management and Research
- Neurogenetic and Muscular Disorders Research
- Congenital heart defects research
- Cardiac, Anesthesia and Surgical Outcomes
- Pulmonary Hypertension Research and Treatments
Leiden University Medical Center
2017-2023
Institute of Cardiology
2020
Amsterdam Neuroscience
2019
Amsterdam University Medical Centers
2019
Leiden University
2017-2018
Cleveland Clinic
2017
AZ Sint-Jan
2017
The value of left atrial (LA) diameter, volume, and strain to risk stratify hypertrophic cardiomyopathy patients for new-onset fibrillation (AF) was explored.A total 242 without AF history were evaluated by (speckle-tracking) echocardiography. During mean follow-up 4.8±3.7 years, 41 (17%) developed AF. Multivariable analysis showed LA volume (≥37 mL/m2; hazard ratio, 2.68; 95% confidence interval, 1.30-5.54; P=0.008) (≤23.4%; 3.22; 1.50-6.88; P=0.003), but not diameter (≥45 mm; 1.67;...
•Myocardial work parameters are impaired in patients with HCM.•CW is associated adverse events HCM.•Segmental differences of CW were observed among HCM phenotypes. BackgroundNoninvasive left ventricular (LV) pressure-strain loop analysis emerging as a new echocardiographic method to evaluate LV function, integrating longitudinal strain by speckle-tracking and sphygmomanometrically measured blood pressure estimate myocardial work. The aims this study (1) describe global segmental hypertrophic...
Current methods for predicting adverse events in patients with hypertrophic cardiomyopathy are still limited. Left ventricular global longitudinal strain (GLS) and left atrial volume index (LAVI) have been recently proposed as novel prognostic factors several cardiovascular diseases. The objective of this study was to evaluate the value GLS LAVI cardiomyopathy.Two-dimensional echocardiography performed 427 (66% men, age 52±15 years), were assessed. During follow-up, primary end point...
Objective Mitral valve prolapse (MVP) has been associated with ventricular arrhythmias (VA), but little is known about VA in patients significant primary mitral regurgitation (MR). Our aim was to describe the prevalence of symptomatic MVP (fibro-elastic deficiency or Barlow’s disease) referred for (MV) surgery because moderate-to-severe MR, and identify clinical, electrocardiographic, standard advanced echocardiographic parameters VA. Methods 610 consecutive (64±12 years, 36% female) were...
Purpose Although a familial distribution has been documented, the genetic aetiology of mitral valve prolapse (MVP) is largely unknown, with only four genes identified so far: FLNA , DCHS1 DZIP1 and PLD1 . The aim this study was to evaluate yield in known causative identify possible novel associated MVP using heart gene panel based on exome sequencing. Methods Patients were referred for counselling when positive family history reported and/or Barlow’s disease diagnosed. In total, 101 probands...
In mitral valve prolapse (MVP), leaflet thickening has recently been suggested to be due, in addition a myxomatous degeneration, the presence of superimposed tissue (SIT), defined as an additional fibrous layer on top original leaflet. The mechanisms SIT formation are currently unknown. We hypothesized that would result from excessive stress and we used unique ex vivo model assess correlation between remodelling type location mechanical elucidate underlying formation.Human diseased valves...
Barlow's disease (BD) is characterized by thick, redundant mitral valve (MV) leaflets, which can lead to prolapse and significant regurgitation (MR). MV annular abnormalities are also commonly observed increasingly recognized as possible primary pathology, with leaflet thickening being secondary increased stress on the apparatus. To provide more insights into this hypothesis, evolution of over time in patients BD was assessed.A total 64 (54 ± 12 years, 72% male) who underwent surgery had...
Genetic, dilated cardiomyopathy (DCM) can be caused by a large variety of mutations. Mutation carriers are often asymptomatic until DCM is well established, presenting with heart failure, arrhythmias, or sudden cardiac death. Preventive strategies only applied if detected early. Echocardiographic, left ventricular (LV) global longitudinal strain (GLS) promising tool for early diagnosis, i.e. before decrease in LV ejection fraction (EF) has occurred. We, therefore, investigated the role GLS...
Mutations in the myosin heavy chain 7 (MYH7) gene commonly cause cardiomyopathy but are less frequently associated with congenital heart defects.In this study, we describe a mutation MYH7 gene, c. 5754C > G; p. (Asn1918Lys), present 15 probands and 65 family members.Of 80 carriers (age range 0-88 years), 46 (57.5%) had (mainly dilated (DCM)) seven (8.8%) defect. Childhood onset of was almost 10% carriers. However, only slight majority (53.7%) left ventricular ejection fraction reduced no...
Barlow's disease is the most severe form of degenerative mitral valve disease, commonly characterized by bileaflet prolapse. Abnormal annular dynamics typically present and results in functional prolapse leaflets that may be addressed with stabilization alone.Between January 2001 December 2015, 128 patients underwent repair. This included anterior leaflet (AMVL) repair 70 patients, whereas 58 were identified as having no specific AMVL During course study, proportion undergoing decreased (77%...
Following mitral valve repair for Barlow's disease, recurrent regurgitation (MR) is believed to occur frequently and mainly attributed disease progression.Between January 2000 December 2015, 180 patients (40% women, mean age 58.7 ± 13.5 years) with underwent repair. To provide a longitudinal assessment of durability, multistate model interval-censored observations (4 states: 1, Grade 0/1+ MR; 2, 2+ 3, 3+/4+ 4, reintervention/death) was developed. The mechanism MR assessed...
Abstract Background Initial studies have suggested the familial clustering of mitral valve prolapse, but most them were either community based among unselected individuals or applied non-specific diagnostic criteria. Therefore little is known about distribution regurgitation in a referral-type population with more severe prolapse phenotype. The objective this study was to evaluate presence patients undergoing surgery for differentiating Barlow's disease, Barlow forme fruste and fibro-elastic...
Abstract Aims Atrial fibrillation (AF) is frequently observed in hypertrophic cardiomyopathy (HCM) and associated with poor clinical outcome. Total atrial conduction time, estimated by tissue Doppler imaging (TDI), the so-called PA-TDI duration, reflects left (LA) structural electrical remodelling. The aim of this study was to evaluate association between new-onset AF patients HCM. Methods results From a large cohort HCM, 208 (64% male, mean age 53 ± 14 years) without were selected. duration...
Abstract OBJECTIVES The risk factors and clinical effect of elevated mitral valve (MV) gradients after repair for degenerative disease remain insufficiently understood. METHODS Between January 2004 December 2015, a total 484 patients underwent disease. A true-sized full annuloplasty ring was implanted in all cases. We analysed the preoperative intraoperative on postrepair gradient. Additionally, we explored long-term outcomes. RESULTS On linear regression analysis, MV were associated with...
Abstract Implementation of point-of-care HbA1c devices in the preoperative outpatient clinic might facilitate early diagnosis glycemic disturbances overweight or obese patients undergoing surgery, but validation studies this setting do not exist. We determined level agreement between a and laboratory test non-diabetic visiting for risk profiling. Point-of-care levels were measured whole blood obtained by finger prick (Siemens DCA Vantage analyzer) hemolysed EDTA central (LAB). Bland Altman...
Chordal replacement techniques are progressively used to treat posterior mitral valve leaflet (PMVL) prolapse while resection remains commonly in use address excessive tissue. For tissue height, shortening neochords can be alternatively. Use of chordal has been suggested result lower diastolic transvalvular gradients, higher freedom from reoperation and improved left ventricular function.From 1/2005 12/2016, 150 patients underwent repair for isolated PMVL with Excessive height was treated by...