A5028408861- Spectroscopy and Laser Applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Spectroscopy and Quantum Chemical Studies
- Spectroscopy and Chemometric Analyses
- Infrared Thermography in Medicine
- Advanced MRI Techniques and Applications
- Advanced Fiber Optic Sensors
- Genetics, Bioinformatics, and Biomedical Research
- Thermography and Photoacoustic Techniques
- Laser Design and Applications
- Photoreceptor and optogenetics research
- Magnetic properties of thin films
- thermodynamics and calorimetric analyses
- NMR spectroscopy and applications
- Radiomics and Machine Learning in Medical Imaging
- Molecular spectroscopy and chirality
- Atmospheric and Environmental Gas Dynamics
University of Illinois Urbana-Champaign
2020-2025
University of Illinois System
2023-2024
Urbana University
2022
Chemical imaging, especially mid-infrared spectroscopic microscopy, enables label-free biomedical analyses while achieving expansive molecular sensitivity. However, its slow speed and poor image quality impede widespread adoption. We present a microscope that provides high-throughput recording, low noise, high spatial resolution where the bottom-up design of optical train facilitates dual-axis galvo laser scanning diffraction-limited focal point over large areas using custom, compound,...
Fourier-transform infrared spectroscopy (FTIR) is a powerful analytical method not only for the chemical identification of solid, liquid, and gas species but also quantification their concentration. However, capability FTIR significantly hindered when analyte surrounded by strong IR absorbing medium, such as liquid solutions. To overcome this limit, here we develop an fiber microprobe that can be inserted into medium obtain full spectra at points interest. benchmark endoscopic method, insert...
Pathology remains a labor-intensive discipline, relying on workflows rooted in practices established over century ago. Despite incremental technological advancements, the diagnostic process—from tissue preparation to interpretation—still heavily depends thinly sliced sections stained and examined under brightfield microscopy by skilled pathologists. Difficult cases often necessitate iterative staining or complex immunohistochemistry (IHC) analyses. However, recent emergence of machine...
Broadly tunable mid-infrared (IR) lasers, including quantum cascade lasers (QCL), are an asset for vibrational spectroscopy wherein high-intensity, coherent illumination can target specific spectral bands rapid, direct chemical detection with microscopic localization. These emerging spectrometers capable of high measurement throughputs large detector signals from the high-intensity and fast speeds as short a single laser pulse, challenging decades old benchmarks Fourier transform infrared...
Quantum cascade lasers (QCLs) have presented a new chapter for the development of infrared spectroscopy its high throughput and ability to tune absorption bands interest. However, compared conventional thermal sources, output stability QCLs is limiting factor. Specifically, noise associated with pulse-to-pulse instability specific concern as we design faster more sensitive spectrometers. Here, demonstrate dual-detector approach reference measurements intensity illuminating sample in...
Fourier-transform infrared spectroscopy (FTIR) is a powerful analytical method for not only the chemical identification of solid, liquid, and gas species, but also quantification their concentration. However, capability FTIR significantly hindered when analyte surrounded by strong IR absorbing medium, such as liquid solutions. To overcome this limit, here we develop an fiber microprobe that can be inserted into obtain full spectra at points interest. benchmark endoscopic method, insert bulk...
Infrared spectroscopic imaging combines the ability to record molecular content with visualize chemistry in its spatial diversity. Given need a significantly larger quantity of data than typical microscopy image (MB vs. GB) and extensive bandwidth spectra (~10 m), trade-offs often have be made between closely related considerations signal noise ratio, spatial-spectral coverage, resolution optical arrangements. Here, we present path from rigorous theory modeling design realizing advantages...
This work presents a new method to achieve accelerated, high-resolution magnetic resonance spectroscopic imaging (MRSI) with spin-echo excitations. A data acquisition strategy is proposed that integrates adiabatic refocusing, elimination of lipid suppression, rapid spatiospectral encoding sparse (k,t)-space sampling, and interleaved water navigators. integration leads significantly improved combination volume coverage, spatial resolution (approximately 3 × 3.4 4 mm3) speed (< 10 minutes),...