A5085892818- Telomeres, Telomerase, and Senescence
- Insect and Arachnid Ecology and Behavior
- Genetics, Aging, and Longevity in Model Organisms
- Advanced biosensing and bioanalysis techniques
- Meat and Animal Product Quality
- Amino Acid Enzymes and Metabolism
- Bee Products Chemical Analysis
- Primate Behavior and Ecology
- Genomics and Chromatin Dynamics
- Biochemical effects in animals
- DNA and Nucleic Acid Chemistry
Charles University
2021-2024
Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry
2021-2024
Czech Academy of Sciences
2024
National Cancer Institute
2024
National Institutes of Health
2024
Kings and queens of termites, like other advanced eusocial insects, are endowed with admirable longevity, which dramatically exceeds the life expectancies their non-reproducing nest-mates related solitary insects. In quest to find mechanisms underlying longevity termite reproductives, we focused on somatic maintenance mediated by telomerase. This ribonucleoprotein is well established for pro-longevity functions in vertebrates, thanks primarily its ability telomere extension. However,...
Abstract Kings and queens of termites are endowed with an extraordinary longevity coupled lifelong fecundity. We recently reported that termite kings display a dramatically increased enzymatic activity abundance telomerase in their somatic organs when compared to short-lived workers soldiers. hypothesized this activation may represent non-canonical pro-longevity function, independent its canonical role telomere maintenance. Here, we explore avenue investigate whether the presumed be due...
Patients with ER-negative breast cancer have the worst prognosis of all subtypes, often experiencing rapid recurrence or progression to metastatic disease shortly after diagnosis. Given that metastasis is primary cause mortality in most solid tumors, understanding biology crucial for effective intervention. Using a mouse systems genetics approach, we previously identified 12 genes associated susceptibility. Here, extend those studies identify Resf1 , poorly characterized gene, as novel...
Kings and queens of termites are endowed with an extraordinary longevity coupled lifelong fecundity. We recently reported that termite kings display a dramatically increased enzymatic activity abundance telomerase in their somatic organs when compared to short-lived workers soldiers. hypothesized this activation may represent noncanonical pro-longevity function, independent its canonical role telomere maintenance. Here, we explore avenue investigate whether the presumed be due alternative...